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New sesquiterpenes from Asteriscus graveolens.
Achoub H, Mencherini T, Esposito T, Luca R, Aquino R, Gazzerro P, Zaiter L, Benayache F, Benayache S. Achoub H, et al. Nat Prod Res. 2021 Jul;35(13):2190-2198. doi: 10.1080/14786419.2019.1666390. Epub 2019 Sep 23. Nat Prod Res. 2021. PMID: 31542956
A new acyclic sesquiterpene [7,12-dihydroxy-6,7-dihydro-5,(6) E-dehydronerolidol (3)] and sesquiterpene germacranolide lactone derivatives [9beta-hydroxy-11beta,13-dihydroparthenolide-9-O-beta-D-glucopyranoside (7) and 9alpha-hydroxy-11beta,13-dihydroparthenolide-9- …
A new acyclic sesquiterpene [7,12-dihydroxy-6,7-dihydro-5,(6) E-dehydronerolidol (3)] and sesquiterpene germacranolide lactone derivatives [ …
Substrate promiscuity of enzymes from the sesquiterpene biosynthetic pathways from Artemisia annua and Tanacetum parthenium allows for novel combinatorial sesquiterpene production.
Beyraghdar Kashkooli A, van der Krol AR, Rabe P, Dickschat JS, Bouwmeester H. Beyraghdar Kashkooli A, et al. Metab Eng. 2019 Jul;54:12-23. doi: 10.1016/j.ymben.2019.01.007. Epub 2019 Feb 26. Metab Eng. 2019. PMID: 30822491
Here we used a combinatorial metabolic engineering approach to explore the stereospecific modification activity of the Artemisia annua artemisinic aldehyde 11(13) double bond reductase2 (AaDBR2) on products of the feverfew sesquiterpene biosynthesis pathway (GAS, GAO, COS and PTS …
Here we used a combinatorial metabolic engineering approach to explore the stereospecific modification activity of the Artemisia annua artem …
Constituents of Paramichelia baillonii: a new antitumor germacranolide alkaloid.
Ruangrungsi N, Rivepiboon A, Lange GL, Lee M, Decicco CP, Picha P, Preechanukool K. Ruangrungsi N, et al. J Nat Prod. 1987 Sep-Oct;50(5):891-6. doi: 10.1021/np50053a020. J Nat Prod. 1987. PMID: 3437284
Three of the components had been reported previously: the germacranolide epoxides (--)-dihydroparthenolide [1] and (--)-parthenolide [2] and the oxoaporphinoid alkaloid liriodenine [4]. ...
Three of the components had been reported previously: the germacranolide epoxides (--)-dihydroparthenolide [1] and (--)-parthenolide …
Two new germacranolides from Magnolia grandiflora.
Wu SH, Luo XD, Ma YB, Hao XJ, Zhou J, Wu DG. Wu SH, et al. J Asian Nat Prod Res. 2001;3(2):95-102. doi: 10.1080/10286020108041376. J Asian Nat Prod Res. 2001. PMID: 11407820
Two new sesquiterpenoids, 4,5-epoxy-13-methoxy-1(10)-germacren-12,6-olide and 4,5-epoxy-13-acetoxy-1(10)-germacren-12,6-olide, were isolated from the leaves of Magnolia grandiflora, together with six known compounds, 2alpha-hydroxy-dihydroparthenolide, parthenolide, costun …
Two new sesquiterpenoids, 4,5-epoxy-13-methoxy-1(10)-germacren-12,6-olide and 4,5-epoxy-13-acetoxy-1(10)-germacren-12,6-olide, were isolated …
Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot.
Feltenstein MW, Schühly W, Warnick JE, Fischer NH, Sufka KJ. Feltenstein MW, et al. Pharmacol Biochem Behav. 2004 Oct;79(2):299-302. doi: 10.1016/j.pbb.2004.08.008. Pharmacol Biochem Behav. 2004. PMID: 15501305
Rats received ip injections of either vehicle (propylene glycol), indomethacin (5 mg/kg), 11,13-dihydroparthenolide (20 mg/kg), parthenolide (5 or 20 mg/kg) or enhydrin (5 or 20 mg/kg). ...Parthenolide (20 mg/kg) and enhydrin (20 mg/kg) significantly blocked the hyperalges …
Rats received ip injections of either vehicle (propylene glycol), indomethacin (5 mg/kg), 11,13-dihydroparthenolide (20 mg/kg), parth …
Inhibition and promotion of germination by several sesquiterpenes.
Fischer NH, Weidenhamer JD, Bradow JM. Fischer NH, et al. J Chem Ecol. 1989 Jun;15(6):1785-93. doi: 10.1007/BF01012266. J Chem Ecol. 1989. PMID: 24272182
The sesquiterpene lactones, burrodin, confertiflorin. desacetyl-confertiflorin, dihydroparthenolide, parthenin, and 7alpha-hydroxy-3-desoxyzaluzanin C, and the sesquiterpene ester guayulin A were assayed at concentrations of 1, 10, and 100 muM for effects on seed germinati …
The sesquiterpene lactones, burrodin, confertiflorin. desacetyl-confertiflorin, dihydroparthenolide, parthenin, and 7alpha-hydroxy-3- …
Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda.
Mondranondra IO, Che CT, Rimando AM, Vajrodaya S, Fong HH, Farnsworth NR. Mondranondra IO, et al. Pharm Res. 1990 Dec;7(12):1269-72. doi: 10.1023/a:1015937921880. Pharm Res. 1990. PMID: 2095565
Inactive sesquiterpene lactones obtained during the course of this study included dihydroparthenolide and two new glucosides of dihydrotamaulipin A and dihydroreynosin (1 and 2). ...
Inactive sesquiterpene lactones obtained during the course of this study included dihydroparthenolide and two new glucosides of dihyd …