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1989 5
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1996 1
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1998 2
1999 3
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2024 0

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126 results

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Page 1
GTP-cyclohydrolases: a review.
Blau N, Niederwieser A. Blau N, et al. J Clin Chem Clin Biochem. 1985 Apr;23(4):169-76. J Clin Chem Clin Biochem. 1985. PMID: 3891906 Review.
GTP-cyclohydrolase I (EC 3.5.4.16) converts GTP into D-erythro-7, 8-dihydroneopterin triphosphate, whereas GTP-cyclohydrolase II forms 2,5-diamino-4-oxo-6-(5'-phosphoribosyl) -amino pyrimidine, a possible intermediate in the biosynthesis of riboflavin. ...
GTP-cyclohydrolase I (EC 3.5.4.16) converts GTP into D-erythro-7, 8-dihydroneopterin triphosphate, whereas GTP-cyclohydrolase …
Tetrahydrobiopterin and cytokines.
Werner ER, Werner-Felmayer G, Wachter H. Werner ER, et al. Proc Soc Exp Biol Med. 1993 May;203(1):1-12. doi: 10.3181/00379727-203-43566a. Proc Soc Exp Biol Med. 1993. PMID: 8475129 Review.
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl …
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yield …
Biosynthesis of tetrahydrobiopterin in man.
Curtius HC, Heintel D, Ghisla S, Kuster T, Leimbacher W, Niederwieser A. Curtius HC, et al. J Inherit Metab Dis. 1985;8 Suppl 1:28-33. doi: 10.1007/BF01800656. J Inherit Metab Dis. 1985. PMID: 3930838 Review.
The biosynthesis of tetrahydrobiopterin (BH4) from dihydroneopterin triphosphate (NH2P3) was studied in human liver extract. ...
The biosynthesis of tetrahydrobiopterin (BH4) from dihydroneopterin triphosphate (NH2P3) was studied in human liver extract. . …
Tetrahydrobiopterin biosynthetic pathway and deficiency.
Niederwieser A, Curtius HC. Niederwieser A, et al. Enzyme. 1987;38(1-4):302-11. doi: 10.1159/000469220. Enzyme. 1987. PMID: 3326735 Review.
The enzyme 6-pyruvoyl tetrahydropterin synthase consists of four identical subunits which convert dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin in the presence of magnesium. ...
The enzyme 6-pyruvoyl tetrahydropterin synthase consists of four identical subunits which convert dihydroneopterin triphosphate …
FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
Pribat A, Blaby IK, Lara-Núñez A, Gregory JF 3rd, de Crécy-Lagard V, Hanson AD. Pribat A, et al. J Bacteriol. 2010 Jan;192(2):475-82. doi: 10.1128/JB.01198-09. Epub 2009 Nov 6. J Bacteriol. 2010. PMID: 19897652 Free PMC article.
A comparative genomics analysis implicated the enigmatic folX and folM genes in tetrahydromonapterin synthesis via their phyletic distribution and chromosomal clustering patterns. folX encodes dihydroneopterin triphosphate epimerase, which interconverts dihydrone …
A comparative genomics analysis implicated the enigmatic folX and folM genes in tetrahydromonapterin synthesis via their phyletic distributi …
6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria.
Pribat A, Jeanguenin L, Lara-Núñez A, Ziemak MJ, Hyde JE, de Crécy-Lagard V, Hanson AD. Pribat A, et al. J Bacteriol. 2009 Jul;191(13):4158-65. doi: 10.1128/JB.00416-09. Epub 2009 Apr 24. J Bacteriol. 2009. PMID: 19395485 Free PMC article.
A similar PTPS paralog from the malaria parasite Plasmodium falciparum is known to form HMDHP from dihydroneopterin triphosphate in vitro and has been proposed to provide a bypass to the FolB step in vivo. ...Recombinant bacterial PTPS-III proteins, like the P. falc …
A similar PTPS paralog from the malaria parasite Plasmodium falciparum is known to form HMDHP from dihydroneopterin triphosphate …
Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase.
Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G. Haussmann C, et al. J Biol Chem. 1998 Jul 10;273(28):17418-24. doi: 10.1074/jbc.273.28.17418. J Biol Chem. 1998. PMID: 9651328 Free article.
The gene was subsequently designated folB. The FolB protein shows 30% identity to the paralogous dihydroneopterin-triphosphate epimerase, which is specified by the folX gene located at 2427 kilobases on the E. coli chromosome. ...However, the genome of H. influenzae …
The gene was subsequently designated folB. The FolB protein shows 30% identity to the paralogous dihydroneopterin-triphosphate …
The enzymatic conversion of dihydroneopterin triphosphate to tripolyphosphate and 6-pyruvoyl-tetrahydropterin, an intermediate in the biosynthesis of other pterins in Drosophila melanogaster.
Switchenko AC, Brown GM. Switchenko AC, et al. J Biol Chem. 1985 Mar 10;260(5):2945-51. J Biol Chem. 1985. PMID: 3919013 Free article.
This enzyme catalyzes the Mg2+-dependent conversion of 2-amino-4-oxo-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydrop teridine triphosphate (dihydroneopterin triphosphate or H2-NTP) to two products, one of which we have identified as tripolyphosphate. ...
This enzyme catalyzes the Mg2+-dependent conversion of 2-amino-4-oxo-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydrop teridine triphosph …
Functional promiscuity of the COG0720 family.
Phillips G, Grochowski LL, Bonnett S, Xu H, Bailly M, Blaby-Haas C, El Yacoubi B, Iwata-Reuyl D, White RH, de Crécy-Lagard V. Phillips G, et al. ACS Chem Biol. 2012 Jan 20;7(1):197-209. doi: 10.1021/cb200329f. Epub 2011 Oct 26. ACS Chem Biol. 2012. PMID: 21999246 Free PMC article.
A subset of these proteins includes the 6-pyruvoyltetrahydropterin (PTPS-II), PTPS-III, and PTPS-I homologues, all members of the COG0720 family that have been previously shown to transform 7,8-dihydroneopterin triphosphate (H(2)NTP) into different products. PTPS-II …
A subset of these proteins includes the 6-pyruvoyltetrahydropterin (PTPS-II), PTPS-III, and PTPS-I homologues, all members of the COG0720 fa …
Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity.
Hara S, Fukumura S, Ichinose H. Hara S, et al. J Biol Chem. 2019 Jan 25;294(4):1420-1427. doi: 10.1074/jbc.RA118.005280. Epub 2018 Dec 4. J Biol Chem. 2019. PMID: 30514762 Free PMC article.
6-Pyruvoyl tetrahydropterin synthase (PTS) converts 7,8-dihydroneopterin triphosphate into 6-pyruvoyltetrahydropterin and is a critical enzyme for the de novo synthesis of tetrahydrobiopterin, an essential cofactor for aromatic amino acid hydroxylases and nitric-oxi …
6-Pyruvoyl tetrahydropterin synthase (PTS) converts 7,8-dihydroneopterin triphosphate into 6-pyruvoyltetrahydropterin and is a …
126 results