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1958 1
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1986 2
1990 1
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28 results

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Page 1
N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics.
Schneider O, Zehl M, Ueoka R, Rückert C, Buche T, Jiang Y, Li QY, Piel J, Zotchev SB. Schneider O, et al. mBio. 2022 Oct 26;13(5):e0178922. doi: 10.1128/mbio.01789-22. Epub 2022 Aug 30. mBio. 2022. PMID: 36040031 Free PMC article.
The antibiotic desertomycin A and its previously undescribed inactive N-succinylated analogue, desertomycin X, were isolated from Streptomyces sp. strain YIM 121038. Genome sequencing and analysis readily identified the desertomycin biosynthetic gene cluster …
The antibiotic desertomycin A and its previously undescribed inactive N-succinylated analogue, desertomycin X, were isolated f …
An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics.
Hong H, Samborskyy M, Lindner F, Leadlay PF. Hong H, et al. Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1118-23. doi: 10.1002/anie.201509300. Epub 2015 Dec 2. Angew Chem Int Ed Engl. 2016. PMID: 26630438 Free PMC article.
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring. ...We have now identified candidate amidinohydrolase genes within the desertomycin and primycin clusters. Deletion of the putative desertomycin amidinohydrolase gene dstH in Streptomy …
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring. ...We have now identified candidate amidinohydrolase gene …
A world tour in the name of natural products.
Bailly C. Bailly C. Phytomedicine. 2022 Jun;100:154080. doi: 10.1016/j.phymed.2022.154080. Epub 2022 Mar 27. Phytomedicine. 2022. PMID: 35405614
This virtual journey, without bordure or wall, brings us to the highest mountains (himalayamine), the deepest oceans (pacificins) and the largest deserts (desertomycin). CONCLUSION: In the current period of COVID-19 pandemia, with restricted opportunities for international …
This virtual journey, without bordure or wall, brings us to the highest mountains (himalayamine), the deepest oceans (pacificins) and the la …
Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin.
Hashimoto T, Kozone I, Hashimoto J, Suenaga H, Fujie M, Satoh N, Ikeda H, Shin-Ya K. Hashimoto T, et al. J Antibiot (Tokyo). 2020 Sep;73(9):650-654. doi: 10.1038/s41429-020-0319-0. Epub 2020 May 26. J Antibiot (Tokyo). 2020. PMID: 32457441
From our in-house microbial genome database of secondary metabolite producers, we identified a candidate biosynthetic gene cluster for desertomycin from Streptomyces nobilis JCM4274. We report herein the cloning of the 127-kb entire gene cluster for desertomycin bio …
From our in-house microbial genome database of secondary metabolite producers, we identified a candidate biosynthetic gene cluster for de …
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Martín J, Otero L, Palacios-Gutiérrez JJ, Fernández J, Mohamedi Y, Fontanil T, Salmón M, Cal S, Reyes F, García LA, Blanco G. Braña AF, et al. Mar Drugs. 2019 Feb 12;17(2):114. doi: 10.3390/md17020114. Mar Drugs. 2019. PMID: 30759848 Free PMC article.
The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. ...Desertomycin G also disp …
The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong ant …
Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique.
Mohamed OG, Dorandish S, Lindow R, Steltz M, Shoukat I, Shoukat M, Chehade H, Baghdadi S, McAlister-Raeburn M, Kamal A, Abebe D, Ali K, Ivy C, Antonova M, Schultz P, Angell M, Clemans D, Friebe T, Sherman D, Casper AM, Price PA, Tripathi A. Mohamed OG, et al. Mar Drugs. 2021 Jul 27;19(8):424. doi: 10.3390/md19080424. Mar Drugs. 2021. PMID: 34436264 Free PMC article.
We utilized a targeted approach that coupled mass spectrometry data with bioactivity, yielding a new macrolactone class of metabolite, desertomycin H. In this study, we successfully demonstrate a concept that significantly increased our ability to quickly and efficiently i …
We utilized a targeted approach that coupled mass spectrometry data with bioactivity, yielding a new macrolactone class of metabolite, de …
Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity.
Krespach MKC, Stroe MC, Flak M, Komor AJ, Nietzsche S, Sasso S, Hertweck C, Brakhage AA. Krespach MKC, et al. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2100892118. doi: 10.1073/pnas.2100892118. Proc Natl Acad Sci U S A. 2021. PMID: 34740967 Free PMC article.
The presence of marginolactone biosynthesis gene clusters in numerous streptomycetes, their ubiquity in soil, and our observation that other marginolactones such as desertomycin A and monazomycin also trigger the formation of gloeocapsoids suggests a cross-kingdom competit …
The presence of marginolactone biosynthesis gene clusters in numerous streptomycetes, their ubiquity in soil, and our observation that other …
Desertomycin: purification and physical-chemical properties.
Dolak LA, Reusser F, Baczynskyj L, Mizsak SA, Hannon BR, Castle TM. Dolak LA, et al. J Antibiot (Tokyo). 1983 Jan;36(1):13-9. doi: 10.7164/antibiotics.36.13. J Antibiot (Tokyo). 1983. PMID: 6678910 Free article.
Desertomycin was isolated from Streptomyces macronensis Dietz sp. nov. ...Mild acid hydrolysis yielded mannose but contrary to published reports, glutamic acid is not a constituent of desertomycin....
Desertomycin was isolated from Streptomyces macronensis Dietz sp. nov. ...Mild acid hydrolysis yielded mannose but contrary to publis …
New macrolactone of the desertomycin family from Streptomyces spectabilis.
Ivanova V. Ivanova V. Prep Biochem Biotechnol. 1997 Feb;27(1):19-38. doi: 10.1080/10826069708001275. Prep Biochem Biotechnol. 1997. PMID: 9090721
The non-polyenic macrocyclic antibiotic complex 1012 was isolated from the culture broth of a strain Streptomyces spectabilis 1. The complex was found to belong to the desertomycin complex. Three main compounds of complex 1012 were separated and purified by preparative chr …
The non-polyenic macrocyclic antibiotic complex 1012 was isolated from the culture broth of a strain Streptomyces spectabilis 1. The complex …
28 results