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1980 1
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Page 1
Dactimicin, a new aminoglycoside: in vitro activity, post-antibiotic effect and interaction with other antibiotics.
Paglia P, Molinari G, Pesce A, Debbia EA. Paglia P, et al. Eur J Clin Microbiol Infect Dis. 1989 Jul;8(7):639-43. doi: 10.1007/BF01968148. Eur J Clin Microbiol Infect Dis. 1989. PMID: 2506028
Dactimicin-ceftazidime and amikacin-ceftazidime were the most effective combinations, demonstrating synergism against 91% and 95% of the isolates respectively. ...An average post-antibiotic effect of 0.6 h was also seen when dactimicin was combined with piperacillin …
Dactimicin-ceftazidime and amikacin-ceftazidime were the most effective combinations, demonstrating synergism against 91% and 95% of …
In vitro activity of dactimicin, a novel pseudodisaccharide aminoglycoside, compared with activities of other aminoglycosides.
Gu JW, Neu HC. Gu JW, et al. Antimicrob Agents Chemother. 1989 Nov;33(11):1998-2003. doi: 10.1128/AAC.33.11.1998. Antimicrob Agents Chemother. 1989. PMID: 2514625 Free PMC article.
Dactimicin inhibited 90% of isolates from the family Enterobacteriaceae at a concentration of less than or equal to 4 micrograms/ml. ...Dactimicin in combination with piperacillin acted synergistically against 75% of Escherichia coli, K. pneumoniae, S. marcescens, a …
Dactimicin inhibited 90% of isolates from the family Enterobacteriaceae at a concentration of less than or equal to 4 micrograms/ml. …
In vitro and in vivo antibacterial activities of dactimicin, a novel pseudodisaccharide aminoglycoside, compared with those of other aminoglycoside antibiotics.
Matsuhashi Y, Yoshida T, Hara T, Kazuno Y, Inouye S. Matsuhashi Y, et al. Antimicrob Agents Chemother. 1985 Apr;27(4):589-94. doi: 10.1128/AAC.27.4.589. Antimicrob Agents Chemother. 1985. PMID: 3873901 Free PMC article.
Dactimicin and astromicin were active against many gentamicin- and amikacin-resistant bacteria expressing aminoglycoside-modifying enzymes, with the exception of aminoglycoside 3-acetyltransferase. However, dactimicin was more resistant than astromicin to inactivati …
Dactimicin and astromicin were active against many gentamicin- and amikacin-resistant bacteria expressing aminoglycoside-modifying en …
Studies on a new aminoglycoside antibiotic, dactimicin. II. Isolation, structure and chemical degradation.
Ohba K, Tsuruoka T, Mizutani K, Kato N, Omoto S, Ezaki N, Inouye S, Niida T, Watanabe K. Ohba K, et al. J Antibiot (Tokyo). 1981 Sep;34(9):1090-100. doi: 10.7164/antibiotics.34.1090. J Antibiot (Tokyo). 1981. PMID: 7328051 Free article.
A new aminoglycoside antibiotic, dactimicin produced by a Dactylosporangium matsuzakiense SF-2052 has been isolated by column chromatography on a cation-exchange resin and CM-sephadex. ...Alkaline hydrolysis of dactimicin afforded 1-N-(N-formylglycyl)fortimicin B, f …
A new aminoglycoside antibiotic, dactimicin produced by a Dactylosporangium matsuzakiense SF-2052 has been isolated by column chromat …
Comparative nephrotoxicity and tissue accumulation of dactimicin, amikacin and gentamicin.
Bonadio M, Maccanti O, Giovannini L, Bertelli AA, Scalori V, Alessandrì MG, Bertelli A. Bonadio M, et al. Drugs Exp Clin Res. 1987;13(12):747-50. Drugs Exp Clin Res. 1987. PMID: 3447878
Few data have so far been reported on dactimicin tissue accumulation or its potential nephrotoxicity. In this study, nephrotoxicity and renal tissue concentrations of gentamicin, amikacin and dactimicin were compared in Wistar rats. ...Consequently a much higher acc …
Few data have so far been reported on dactimicin tissue accumulation or its potential nephrotoxicity. In this study, nephrotoxicity a …
Nephrotoxicity of dactimicin, a novel pseudo-disaccharide aminoglycoside possessing the N-formimidoyl group, compared with that of astromicin, amikacin and other aminoglycoside antibiotics in animals.
Inouye S, Niizato T, Shomura T, Kitasato I. Inouye S, et al. Drugs Exp Clin Res. 1989;15(5):189-209. Drugs Exp Clin Res. 1989. PMID: 2791871
In a detailed comparison between dactimicin and astromicin at 20, 40, 80, 120, 180 and 270 mg/kg for 11 or 30 days, dactimicin induced fewer changes in nucleated cells and NAG at high dosages. ...When injected intramuscularly in rats, dactimicin and astromici …
In a detailed comparison between dactimicin and astromicin at 20, 40, 80, 120, 180 and 270 mg/kg for 11 or 30 days, dactimicin …
In vitro activity of dactimicin and other aminoglycosides against bacteria producing aminoglycoside-modifying enzymes.
Felmingham D, Jones K. Felmingham D, et al. Drugs Exp Clin Res. 1989;15(3):133-6. Drugs Exp Clin Res. 1989. PMID: 2752913
Dactimicin is a new pseudo-disaccharide aminoglycoside, originally isolated from cultures of Dactylosporangium matsuzakienzae sp. nov., which is chemically related to astromicin. ...Dactimicin was inactivated by a combination of a phosphotransferase (APH) APH(2") an …
Dactimicin is a new pseudo-disaccharide aminoglycoside, originally isolated from cultures of Dactylosporangium matsuzakienzae sp. nov …
In vitro bactericidal activity and post-antibiotic effect of dactimicin, a new aminoglycoside, alone and in combination with other antibiotics.
Debbia EA, Schito GC, Stefani S, Nicoletti G. Debbia EA, et al. Drugs Exp Clin Res. 1989;15(3):125-8. Drugs Exp Clin Res. 1989. PMID: 2752911
With the Pseudomonas isolates, indifference prevailed with dactimicin, whereas synergism was observed with amikacin in combination with the other drugs. ...Dactimicin induced a post-antibiotic effect (PAE) which ranged from about 1 h with Enterobacter cloacae to 3 h …
With the Pseudomonas isolates, indifference prevailed with dactimicin, whereas synergism was observed with amikacin in combination wi …
Efficacy of dactimicin in the treatment of experimentally induced intra-abdominal infections.
Nord CE, Lahnborg G. Nord CE, et al. Drugs Exp Clin Res. 1989;15(3):115-8. Drugs Exp Clin Res. 1989. PMID: 2752909
Many of the untreated animals (70%) died within 2 days. Within 7 days 40% of the animals receiving dactimicin died. Animals treated with dactimicin plus metronidazole or gentamicin plus metronidazole had a significantly decreased mortality and increased cure rates d …
Many of the untreated animals (70%) died within 2 days. Within 7 days 40% of the animals receiving dactimicin died. Animals treated w …
Stability of dactimicin to aminoglycoside-modifying enzymes.
Gomez-Lus R, Marco MA, Gomez-Lus ML. Gomez-Lus R, et al. Drugs Exp Clin Res. 1987;13(12):731-5. Drugs Exp Clin Res. 1987. PMID: 3447876
Dactimicin was active against strains expressing the activities of aminoglycoside acetylating enzymes [AAC(3)-II, III, IV and V, AAC(2'), AAC(6')-I and II], aminoglycoside-nucleotidylating enzymes [ANT(2"), AAD(3")] and aminoglycoside-phosphorylating enzymes [APH(3')-I-II …
Dactimicin was active against strains expressing the activities of aminoglycoside acetylating enzymes [AAC(3)-II, III, IV and V, AAC( …
37 results