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Novel Mechanistic Insight into the Anticancer Activity of Cucurbitacin D against Pancreatic Cancer (Cuc D Attenuates Pancreatic Cancer).
Sikander M, Malik S, Khan S, Kumari S, Chauhan N, Khan P, Halaweish FT, Chauhan B, Yallapu MM, Jaggi M, Chauhan SC. Sikander M, et al. Cells. 2019 Dec 31;9(1):103. doi: 10.3390/cells9010103. Cells. 2019. PMID: 31906106 Free PMC article.
Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has shown excellent anticancer properties in various models. ...
Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has sho …
Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer.
Sikander M, Hafeez BB, Malik S, Alsayari A, Halaweish FT, Yallapu MM, Chauhan SC, Jaggi M. Sikander M, et al. Sci Rep. 2016 Nov 8;6:36594. doi: 10.1038/srep36594. Sci Rep. 2016. PMID: 27824155 Free PMC article.
IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. ...These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical cancer....
IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. ...These results demonstrate t …
Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer.
Sikander M, Malik S, Chauhan N, Khan P, Kumari S, Kashyap VK, Khan S, Ganju A, Halaweish FT, Yallapu MM, Jaggi M, Chauhan SC. Sikander M, et al. Cancers (Basel). 2019 Mar 14;11(3):364. doi: 10.3390/cancers11030364. Cancers (Basel). 2019. PMID: 30875788 Free PMC article.
Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastasis. Herein, we report that cucurbitacin D (Cuc D) effectively inhibits glucose uptake and lactate production in metastatic PrC …
Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastas …
Cucurbitacin D is a new inflammasome activator in macrophages.
Song Y, Ding N, Kanazawa T, Yamashita U, Yoshida Y. Song Y, et al. Int Immunopharmacol. 2013 Dec;17(4):1044-50. doi: 10.1016/j.intimp.2013.10.003. Epub 2013 Oct 16. Int Immunopharmacol. 2013. PMID: 24140411
We previously reported that cucurbitacin D isolated from Trichosanthes kirilowii has anti-tumor roles to leukemia cells. ...Importantly, cucurbitacin D has further been shown to induce inflammasome activation independent of ERK1/2 activation. ...
We previously reported that cucurbitacin D isolated from Trichosanthes kirilowii has anti-tumor roles to leukemia cells. ...Im …
The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain.
Park KT, Kim S, Choi I, Han IH, Bae H, Kim W. Park KT, et al. Front Pharmacol. 2023 Jan 4;13:1055264. doi: 10.3389/fphar.2022.1055264. eCollection 2022. Front Pharmacol. 2023. PMID: 36686685 Free PMC article.
However, as cucurbitacin B showed a more toxic effect on non-cancerous (RAW 264.7) cells, further experiments were conducted with cucurbitacin D. The cucurbitacin D dose-dependently (0.025, 0.1, and 0.5 mg/kg) attenuated both allodynia types. ...Altoge …
However, as cucurbitacin B showed a more toxic effect on non-cancerous (RAW 264.7) cells, further experiments were conducted with cucurbi …
Analysis of Active Compounds Using Target Protein Cofilin-Cucurbitacins in Cytotoxic Plant Bryonia cretica.
Nakashima S, Oda Y, Morita M, Ohta A, Morikawa T, Matsuda H, Nakamura S. Nakashima S, et al. Toxins (Basel). 2022 Mar 16;14(3):212. doi: 10.3390/toxins14030212. Toxins (Basel). 2022. PMID: 35324709 Free PMC article.
We conducted LC-MS analysis using information from our previous study. The peaks in the HPLC profile were identified as cucurbitacin D, isocucurbitacin D, and cucurbitacin I. As far as we know, there is no known study of the activity of isocucurbitacin D in this res …
We conducted LC-MS analysis using information from our previous study. The peaks in the HPLC profile were identified as cucurbitacin …
Anti-HIV Activity of Cucurbitacin-D against Cigarette Smoke Condensate-Induced HIV Replication in the U1 Macrophages.
Kodidela S, Sinha N, Kumar A, Kumar S. Kodidela S, et al. Viruses. 2021 May 27;13(6):1004. doi: 10.3390/v13061004. Viruses. 2021. PMID: 34072078 Free PMC article.
In this study, we investigated the anti-HIV effect of a chemodietary agent, Cucurbitacin-D (Cur-D), in HIV-infected macrophages using an in-vitro blood-brain barrier (BBB) model. ...
In this study, we investigated the anti-HIV effect of a chemodietary agent, Cucurbitacin-D (Cur-D), in HIV-infected macrophage …
Metabolome and Transcriptome Analyses of Cucurbitacin Biosynthesis in Luffa (Luffa acutangula).
Zhao G, Wang M, Luo C, Li J, Gong H, Zheng X, Liu X, Luo J, Wu H. Zhao G, et al. Front Plant Sci. 2022 Jun 7;13:886870. doi: 10.3389/fpls.2022.886870. eCollection 2022. Front Plant Sci. 2022. PMID: 35747880 Free PMC article.
Of these, 131 metabolites showed significant differences between bitter (WM709) and non-bitter (S1174) Luffa fruits. The levels of isocucurbitacin B, cucurbitacin D, 23,24-dihydro cucurbitacin E, cucurbitacin F were significantly higher in bitter than in non-bitter …
Of these, 131 metabolites showed significant differences between bitter (WM709) and non-bitter (S1174) Luffa fruits. The levels of isocucurb …
HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy.
Tavares MR, Hrabánková K, Konefał R, Kaňa M, Říhová B, Etrych T, Šírová M, Chytil P. Tavares MR, et al. Pharmaceutics. 2021 Jan 28;13(2):179. doi: 10.3390/pharmaceutics13020179. Pharmaceutics. 2021. PMID: 33525658 Free PMC article.
These linear or self-assembled micellar conjugates, containing immunomodulatory agent cucurbitacin-D (CuD) or the anticancer drug doxorubicin (Dox) covalently bound by the hydrolytically degradable hydrazone bond, showed a hydrodynamic size of 10-30 nm in aqueous so …
These linear or self-assembled micellar conjugates, containing immunomodulatory agent cucurbitacin-D (CuD) or the anticancer d …
Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery.
Hall JA, Seedarala S, Rice N, Kopel L, Halaweish F, Blagg BS. Hall JA, et al. J Nat Prod. 2015 Apr 24;78(4):873-9. doi: 10.1021/acs.jnatprod.5b00054. Epub 2015 Mar 10. J Nat Prod. 2015. PMID: 25756299 Free PMC article.
Disruption of the Hsp90 heteroprotein complex is an effective strategy to prevent client maturation without induction of the HSR. Cucurbitacin D, isolated from Cucurbita texana, and 3-epi-isocucurbitacin D prevented client maturation without induction of the HSR. …
Disruption of the Hsp90 heteroprotein complex is an effective strategy to prevent client maturation without induction of the HSR. Cucurbi …
64 results