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262 results

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Page 1
Antimetastatic action of the prostacyclin analogue cicaprost in experimental mammary tumors.
Schneider MR, Schirner M, Lichtner RB, Graf H. Schneider MR, et al. Breast Cancer Res Treat. 1996;38(1):133-41. doi: 10.1007/BF01803791. Breast Cancer Res Treat. 1996. PMID: 8825130 Review.
-inoculation of various tumor cell lines. Our data reveal that cicaprost, a metabolically stable and orally active analogue of prostacyclin, has pronounced antimetastatic effects in a series of spontaneously metastasizing rodent tumors. ...As primary tumor growth in vivo o …
-inoculation of various tumor cell lines. Our data reveal that cicaprost, a metabolically stable and orally active analogue of prosta …
The PGI(2) Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4(+) T Cells.
Zhou W, Zhang J, Toki S, Goleniewska K, Johnson MO, Bloodworth MH, Newcomb DC, Peebles RS Jr. Zhou W, et al. J Immunol. 2018 Oct 1;201(7):1936-1945. doi: 10.4049/jimmunol.1700605. Epub 2018 Aug 20. J Immunol. 2018. PMID: 30127087 Free PMC article.
Using wild-type and PGI(2) receptor (IP) knockout mice, we found that the PGI(2) analog cicaprost dose-dependently inhibited IL-33-driven IL-4, IL-5, and IL-13 production by CD4(+) T cells in an IP-specific manner. In addition, cicaprost inhibited IL-33-driven IL-2 …
Using wild-type and PGI(2) receptor (IP) knockout mice, we found that the PGI(2) analog cicaprost dose-dependently inhibited IL-33-dr …
Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.
Sobolewski A, Jourdan KB, Upton PD, Long L, Morrell NW. Sobolewski A, et al. Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L352-9. doi: 10.1152/ajplung.00270.2003. Epub 2004 Apr 23. Am J Physiol Lung Cell Mol Physiol. 2004. PMID: 15107293 Free article.
The aim of this study was to investigate the mechanisms of prostacyclin receptor desensitization using the prostacyclin analog cicaprost in rat pulmonary artery smooth muscle cells (PASMCs). Desensitization of the cAMP response occurred in 63 nM cicaprost after a 6- …
The aim of this study was to investigate the mechanisms of prostacyclin receptor desensitization using the prostacyclin analog cicaprost …
Cell-type- and cell-cycle-specific anti-mitogenesis by cicaprost.
Castagnino P, Kothapalli D, Hawthorne EA, Xu T, Assoian RK. Castagnino P, et al. Prostaglandins Other Lipid Mediat. 2010 Sep;93(1-2):20-4. doi: 10.1016/j.prostaglandins.2010.04.004. Epub 2010 May 10. Prostaglandins Other Lipid Mediat. 2010. PMID: 20457271 Free PMC article.
Rapamycin and cicaprost were both strongly anti-mitogenic in vascular smooth muscle cells (VSMCs). ...Similarly, both rapamycin and cicaprost have been reported to regulate levels of the cdk inhibitor, p27(kip1). ...
Rapamycin and cicaprost were both strongly anti-mitogenic in vascular smooth muscle cells (VSMCs). ...Similarly, both rapamycin and …
Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism.
Orie NN, Fry CH, Clapp LH. Orie NN, et al. Cardiovasc Res. 2006 Jan;69(1):107-15. doi: 10.1016/j.cardiores.2005.08.004. Epub 2005 Sep 23. Cardiovasc Res. 2006. PMID: 16183044
OBJECTIVE: We investigated the role of the inward rectifier potassium (KIR) channel and the cyclic AMP-dependent pathway in mediating vasorelaxation induced by the prostacyclin analogue cicaprost. METHODS: Small vessel myography was used to assess responses to cicaprost …
OBJECTIVE: We investigated the role of the inward rectifier potassium (KIR) channel and the cyclic AMP-dependent pathway in mediating vasore …
Prostacyclin among prostanoids.
Gryglewski RJ. Gryglewski RJ. Pharmacol Rep. 2008 Jan-Feb;60(1):3-11. Pharmacol Rep. 2008. PMID: 18276980 Free article. Review.
Prostacyclin sodium salt and its synthetic stable analogues (iloprost, beraprost, treprostinil, epoprostenol, cicaprost) are useful drugs for the treatment of the advanced critical limb ischemia, e.g. in the course of Buerger's disease, and also for the treatment of pulmon …
Prostacyclin sodium salt and its synthetic stable analogues (iloprost, beraprost, treprostinil, epoprostenol, cicaprost) are useful d …
The stable prostacyclin analogue Cicaprost inhibits metastasis to lungs and lymph nodes in the 13762NF MTLn3 rat mammary carcinoma.
Schirner M, Lichtner RB, Schneider MR. Schirner M, et al. Clin Exp Metastasis. 1994 Jan;12(1):24-30. doi: 10.1007/BF01784330. Clin Exp Metastasis. 1994. PMID: 8287616
The effect of Cicaprost on prevention of lung metastasis, lymph node metastasis and primary tumour growth was investigated. ...The weight of the ipsilateral axillary lymph nodes was diminished by Cicaprost to 30-50% of controls. Moreover, metastasis to the contralat …
The effect of Cicaprost on prevention of lung metastasis, lymph node metastasis and primary tumour growth was investigated. ...The we …
Evidence that Ca2+-activated K+ channels play a major role in mediating the vascular effects of iloprost and cicaprost.
Clapp LH, Turcato S, Hall S, Baloch M. Clapp LH, et al. Eur J Pharmacol. 1998 Sep 4;356(2-3):215-24. doi: 10.1016/s0014-2999(98)00549-4. Eur J Pharmacol. 1998. PMID: 9774252
In endothelial-denuded tissues, maximal relaxations to iloprost, cicaprost or isoprenaline were inhibited by approximately 40-50% with tetraethylammonium or iberiotoxin, both blockers of large conductance Ca2+-activated K+ (BKCa) channels. ...We conclude that BKCa channels …
In endothelial-denuded tissues, maximal relaxations to iloprost, cicaprost or isoprenaline were inhibited by approximately 40-50% wit …
A Prostacyclin Analog, Cicaprost, Exhibits Potent Anti-Inflammatory Activity in Human Primary Immune Cells and a Uveitis Model.
Wang JW, Vu C, Poloso NJ. Wang JW, et al. J Ocul Pharmacol Ther. 2017 Apr;33(3):186-192. doi: 10.1089/jop.2016.0167. Epub 2017 Jan 10. J Ocul Pharmacol Ther. 2017. PMID: 28072560
While constitutively expressed in macrophages, the IP receptor was inducible by LPS stimulation in MoDCs. In a LPS-induced rat uveitis model, cicaprost efficaciously prevents ocular inflammatory cell and protein leakage, as well as inflammatory cytokine release. CONCLUSION …
While constitutively expressed in macrophages, the IP receptor was inducible by LPS stimulation in MoDCs. In a LPS-induced rat uveitis model …
A randomised, double-blind study of cicaprost, an oral prostacyclin analogue, in the treatment of Raynaud's phenomenon secondary to systemic sclerosis.
Lau CS, Belch JJ, Madhok R, Cappell H, Herrick A, Jayson M, Thompson JM. Lau CS, et al. Clin Exp Rheumatol. 1993 Jan-Feb;11(1):35-40. Clin Exp Rheumatol. 1993. PMID: 8453795 Clinical Trial.
For a period of 10 days, 16 patients were given a placebo, 16 received cicaprost 2.5 micrograms tds and 17 received cicaprost 5 micrograms tds. ...The apparent lack of overall significance was probably related to the short treatment period and relatively low doses o …
For a period of 10 days, 16 patients were given a placebo, 16 received cicaprost 2.5 micrograms tds and 17 received cicaprost …
262 results