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2012 1
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Page 1
The Pharmacokinetics of CPZEN-45, a Novel Anti-Tuberculosis Drug, in Guinea Pigs.
Garcia-Contreras L, Hanif SNM, Ibrahim M, Durham P, Hickey AJ. Garcia-Contreras L, et al. Pharmaceutics. 2023 Dec 12;15(12):2758. doi: 10.3390/pharmaceutics15122758. Pharmaceutics. 2023. PMID: 38140098 Free PMC article.
CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant tuberculosis (TB). ...Then, the disposition of CPZEN-45 powders after passive inhalation using consecutive and sequential doses was evaluated. ...
CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant tuberculosis (TB). ...Then, the disposi …
Efficacy of inhaled CPZEN-45 in treating tuberculosis in the guinea pig.
Young EF, Durham PG, Perkowski EF, Malik S, Hickey AJ, Braunstein M. Young EF, et al. Tuberculosis (Edinb). 2022 Jul;135:102207. doi: 10.1016/j.tube.2022.102207. Epub 2022 Apr 5. Tuberculosis (Edinb). 2022. PMID: 35588549 Free article. No abstract available.
Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis.
Salomon JJ, Galeron P, Schulte N, Morow PR, Severynse-Stevens D, Huwer H, Daum N, Lehr CM, Hickey AJ, Ehrhardt C. Salomon JJ, et al. Ther Deliv. 2013 Aug;4(8):915-23. doi: 10.4155/tde.13.62. Ther Deliv. 2013. PMID: 23919471
BACKGROUND: The caprazamycin derivative, CPZEN-45 has previously demonstrated antitubercular activity against Mycobacterium tuberculosis H37Rv. ...CONCLUSION: CPZEN-45 is an interesting new drug candidate with potential to be used in aerosol therapy of …
BACKGROUND: The caprazamycin derivative, CPZEN-45 has previously demonstrated antitubercular activity against Mycobacterium tu …
A Spray-Dried Combination of Capreomycin and CPZEN-45 for Inhaled Tuberculosis Therapy.
Pitner RA, Durham PG, Stewart IE, Reed SG, Cassell GH, Hickey AJ, Carter D. Pitner RA, et al. J Pharm Sci. 2019 Oct;108(10):3302-3311. doi: 10.1016/j.xphs.2019.05.024. Epub 2019 May 29. J Pharm Sci. 2019. PMID: 31152746 Free PMC article.
A variety of drugs have been evaluated for pulmonary delivery as dry powders: capreomycin sulfate has shown efficacy and was safely delivered by inhalation at high doses to human volunteers, whereas CPZEN-45 is a new drug that has also been shown to kill resistant T …
A variety of drugs have been evaluated for pulmonary delivery as dry powders: capreomycin sulfate has shown efficacy and was safely delivere …
Synthesis and biological activity of analogs of CPZEN-45, a novel antituberculosis drug.
Ishizaki Y, Takahashi Y, Kimura T, Inoue M, Hayashi C, Igarashi M. Ishizaki Y, et al. J Antibiot (Tokyo). 2019 Dec;72(12):970-980. doi: 10.1038/s41429-019-0225-5. Epub 2019 Aug 30. J Antibiot (Tokyo). 2019. PMID: 31471594
Analogs of CPZEN-45, which is expected to be a promising new antituberculosis drug that overcomes the shortcomings of caprazamycins, were synthesized and their biological activities were evaluated. The biological activity of analogs 1-3, which converted the anilide …
Analogs of CPZEN-45, which is expected to be a promising new antituberculosis drug that overcomes the shortcomings of caprazam …
Optimization and Scale Up of Spray Dried CPZEN-45 Aerosol Powders for Inhaled Tuberculosis Treatment.
Stewart IE, Durham PG, Sittenauer JM, Barreda AP, Stowell GW, Moody C, Mecham JB, Simpson C, Daily S, Maloney SE, Williams MD, Severynse-Stevens D, Hickey AJ. Stewart IE, et al. Pharm Res. 2022 Dec;39(12):3359-3370. doi: 10.1007/s11095-022-03393-w. Epub 2022 Sep 16. Pharm Res. 2022. PMID: 36114362 Free PMC article.
A number of drugs have been proposed as inhaled therapy for TB, frequently prepared by spray drying. CPZEN-45 is a novel anti-tubercular drug that has poor oral bioavailability but has shown promise when administered via inhalation. METHODS: Excipient-free CPZEN …
A number of drugs have been proposed as inhaled therapy for TB, frequently prepared by spray drying. CPZEN-45 is a novel anti- …
ADVANCES IN PHARMACOTHERAPY OF TUBERCULOSIS.
Pstragowski M, Zbrzezna M, Bujalska-Zadrozny M. Pstragowski M, et al. Acta Pol Pharm. 2017 Jan;74(1):3-11. Acta Pol Pharm. 2017. PMID: 29474756 Free article. Review.
This paper is also focused on some interesting molecules in treating multidrug-resistant tuberculosis which are currently tested in clinical studies: delamanid (dihydro-nitroimidazooxazole derivative, phase III), AZD5847 (oxazolidinone derivative, phase II), pretomanid (nitroimid …
This paper is also focused on some interesting molecules in treating multidrug-resistant tuberculosis which are currently tested in clinical …
Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide.
Nakamura H, Yoshida T, Tsukano C, Takemoto Y. Nakamura H, et al. Org Lett. 2016 May 6;18(9):2300-3. doi: 10.1021/acs.orglett.6b00943. Epub 2016 Apr 18. Org Lett. 2016. PMID: 27088563 Free article.
CPZEN-45 was developed as an antibiotic against Mycobacterium tuberculosis by the chemical modification of caprazamycins. CPZEN-45 has been synthesized in this study by the Cu-catalyzed intramolecular amidation of a complex vinyl iodide precursor beari …
CPZEN-45 was developed as an antibiotic against Mycobacterium tuberculosis by the chemical modification of caprazamycins. C …
Liquid chromatographic determination of CPZEN-45, a novel anti-tubercular drug, in biological samples.
Hanif SN, Hickey AJ, Garcia-Contreras L. Hanif SN, et al. J Pharm Biomed Anal. 2014 Jan;88:370-6. doi: 10.1016/j.jpba.2013.09.014. Epub 2013 Oct 6. J Pharm Biomed Anal. 2014. PMID: 24176740 Free PMC article.
CPZEN-45 is a new drug candidate being considered for the treatment of tuberculosis (TB). ...Recovery of CPZEN-45 from biological samples was >96% of the spiked amount. The limit of detection was 0.05mug/ml and the limit of quantitation was 0.29mug/ …
CPZEN-45 is a new drug candidate being considered for the treatment of tuberculosis (TB). ...Recovery of CPZEN-45 …
Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45.
Ishizaki Y, Hayashi C, Inoue K, Igarashi M, Takahashi Y, Pujari V, Crick DC, Brennan PJ, Nomoto A. Ishizaki Y, et al. J Biol Chem. 2013 Oct 18;288(42):30309-30319. doi: 10.1074/jbc.M113.492173. Epub 2013 Aug 28. J Biol Chem. 2013. PMID: 23986448 Free PMC article.
We isolated the antitubercular agents caprazamycins from the culture of an actinomycete strain and created CPZEN-45 as the most promising derivative of the caprazamycins. Herein, we describe the mode of action of CPZEN-45 first against Bacillus subtili …
We isolated the antitubercular agents caprazamycins from the culture of an actinomycete strain and created CPZEN-45 as the mos …
18 results