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Year Number of Results
1991 3
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1993 4
1994 2
1995 4
1996 1
1997 7
1998 7
1999 10
2000 14
2001 6
2002 9
2003 7
2004 7
2005 7
2006 7
2007 10
2008 12
2009 13
2010 11
2011 10
2012 12
2013 10
2014 13
2015 18
2016 7
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2023 5
2024 1

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252 results

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Page 1
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B.
Yoon MC, Christy MP, Phan VV, Gerwick WH, Hook G, O'Donoghue AJ, Hook V. Yoon MC, et al. Biochemistry. 2022 Feb 15;61(4):228-238. doi: 10.1021/acs.biochem.1c00684. Epub 2022 Feb 4. Biochemistry. 2022. PMID: 35119840 Free PMC article.
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. ...While high levels of CA-074 or CA-074Me (converted by cellular esterases to CA-074) are used in biological studies to inhibit cathepsin B at both acidic and …
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. ...While high levels of CA-074 or …
Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury.
Xu J, Ding Y, Shi C, Yuan F, Sheng X, Liu Y, Xie Y, Lu H, Duan C, Hu J, Jiang L. Xu J, et al. Aging Dis. 2023 Jun 8;15(1):421-43. doi: 10.14336/AD.2023.0509. Online ahead of print. Aging Dis. 2023. PMID: 37307830 Free PMC article.
Furthermore, we discovered that inhibiting cathepsin B (CTSB), specifically with a small-molecule drug, CA-074-methyl ester (CA-074-me), reduced lipid peroxidation and mitochondrial dysfunction in macrophages. We also found that alternatively activated …
Furthermore, we discovered that inhibiting cathepsin B (CTSB), specifically with a small-molecule drug, CA-074-methyl ester ( …
Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells.
Meng Z, Gao M, Wang C, Guan S, Zhang D, Lu J. Meng Z, et al. J Agric Food Chem. 2023 May 10;71(18):7032-7045. doi: 10.1021/acs.jafc.2c07581. Epub 2023 May 4. J Agric Food Chem. 2023. PMID: 37141464
By adding the mitophagy inhibitor cyclosporin A (CsA), LC3-siRNA, the CTSB inhibitor CA-074 methyl ester (CA-074 Me), and the NLRP3 inhibitor MCC950, the aforementioned results were further confirmed. ...
By adding the mitophagy inhibitor cyclosporin A (CsA), LC3-siRNA, the CTSB inhibitor CA-074 methyl ester (CA-074 …
In Silico Drug Repurposing in Multiple Sclerosis Using scRNA-Seq Data.
Shevtsov A, Raevskiy M, Stupnikov A, Medvedeva Y. Shevtsov A, et al. Int J Mol Sci. 2023 Jan 4;24(2):985. doi: 10.3390/ijms24020985. Int J Mol Sci. 2023. PMID: 36674506 Free PMC article.
Using genes from top-activated pathways, we detected several promising small molecules to reverse MS immune cells' transcriptomic signatures, including AG14361, FGIN-1-27, CA-074, ARP 101, Flunisolide, and JAK3 Inhibitor VI. Among these molecules, we also detected a …
Using genes from top-activated pathways, we detected several promising small molecules to reverse MS immune cells' transcriptomic signatures …
Emerging roles of microglial cathepsins in neurodegenerative disease.
Lowry JR, Klegeris A. Lowry JR, et al. Brain Res Bull. 2018 May;139:144-156. doi: 10.1016/j.brainresbull.2018.02.014. Epub 2018 Feb 15. Brain Res Bull. 2018. PMID: 29454581 Review.
Examination of the CNS roles of cathepsins is limited by the shortage of highly selective inhibitors, with CA-074 being the only available specific cathepsin B inhibitor. ...
Examination of the CNS roles of cathepsins is limited by the shortage of highly selective inhibitors, with CA-074 being the on …
Cathepsin-B inhibitor CA-074 attenuates retinopathy and optic neuritis in experimental autoimmune encephalomyelitis induced in SJL/J mice.
Rashid Khan M, Fayaz Ahmad S, Nadeem A, Imam F, Al-Harbi NO, Shahnawaz Khan M, Alsahli M, Alhosaini K. Rashid Khan M, et al. Saudi Pharm J. 2023 Jan;31(1):147-153. doi: 10.1016/j.jsps.2022.11.013. Epub 2022 Nov 23. Saudi Pharm J. 2023. PMID: 36685301 Free PMC article.
A daily dose of 10 mg/kg CA-074 was administered to the EAE mice intraperitoneally for 14 days from day 14 post-immunization until day 28. ...The treatment with CA-074 also reduced the demyelination and axonal injuries in the EAE mice. ...
A daily dose of 10 mg/kg CA-074 was administered to the EAE mice intraperitoneally for 14 days from day 14 post-immunization u …
Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration.
Sharma A, Swetha R, Bajad NG, Ganeshpurkar A, Singh R, Kumar A, Singh SK. Sharma A, et al. Mini Rev Med Chem. 2022;22(15):2012-2023. doi: 10.2174/1389557522666220214095859. Mini Rev Med Chem. 2022. PMID: 35156579 Review.
It also damages neurons present in the CNS region by producing inflammatory responses and generating mitochondrial ROS. However, Cathepsin B inhibitors, i.e., CA-074, can prevent neuronal death in AD patients. The other natural inhibitors are also equally effective …
It also damages neurons present in the CNS region by producing inflammatory responses and generating mitochondrial ROS. However, Cathepsin B …
Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis.
Ansari MA, Nadeem A, Alshammari MA, Attia SM, Bakheet SA, Khan MR, Albekairi TH, Alasmari AF, Alhosaini K, Alqahtani F, Al-Mazroua HA, Ahmad SF. Ansari MA, et al. Exp Neurol. 2022 May;351:113997. doi: 10.1016/j.expneurol.2022.113997. Epub 2022 Feb 2. Exp Neurol. 2022. PMID: 35122866
Following induction of EAE, mice were administered CA-074 (10 mg/kg) intraperitoneally each day, beginning on day 14 and continuing until day 28, and were evaluated for clinical signs. ...We also analyzed the effect of CA-074 on T-bet, IL-17A, RORgamma …
Following induction of EAE, mice were administered CA-074 (10 mg/kg) intraperitoneally each day, beginning on day 14 and conti …
252 results