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Did you mean bruceolides (4 results)?
Anti-malarial activities of acylated bruceolide derivatives.
Murakami N, Umezome T, Mahmud T, Sugimoto M, Kobayashi M, Wataya Y, Kim HS. Murakami N, et al. Bioorg Med Chem Lett. 1998 Mar 3;8(5):459-62. doi: 10.1016/s0960-894x(98)00045-6. Bioorg Med Chem Lett. 1998. PMID: 9871598
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. ...
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxiciti …
A New C22-Quassinoid with Anti-Pancreatic Adenocarcinoma Activity from Seeds of Brucea javanica.
Yang CB, Lu SN, Lu C, Xu MM, Duan JA, Che CT, Zhou J, Zhao M. Yang CB, et al. Chem Biodivers. 2022 Jun;19(6):e202101004. doi: 10.1002/cbdv.202101004. Epub 2022 May 20. Chem Biodivers. 2022. PMID: 35514039
Sergeolide A (1) is the first example of a naturally occurring C22-quassinoid bearing a butenolide group fused the A ring of the bruceolide skeleton from Brucea genus. And this is the first report of the NMR data for desmethyl-bruceines B (2) and C (3) and the crystal stru …
Sergeolide A (1) is the first example of a naturally occurring C22-quassinoid bearing a butenolide group fused the A ring of the bruceoli
Antimalarial agents, 4. Synthesis of a brusatol analog and biological activity of brusatol-related compounds.
Lee KH, Tani S, Imakura Y. Lee KH, et al. J Nat Prod. 1987 Sep-Oct;50(5):847-51. doi: 10.1021/np50053a012. J Nat Prod. 1987. PMID: 3325613
The quassinoids bruceoside-A [1], brusatol [2], and bruceolide [3] were tested for antimalarial activity in vitro against the chloroquine-resistant (Smith) isolates of Plasmodium falciparum. Compound 2 was quite active, 1 was not active, and 3 showed only a trace of activi …
The quassinoids bruceoside-A [1], brusatol [2], and bruceolide [3] were tested for antimalarial activity in vitro against the chloroq …
In vitro cytotoxicity of a series of quassinoids from Brucea javanica fruits against KB cells.
Anderson MM, O'Neill MJ, Phillipson JD, Warhurst DC. Anderson MM, et al. Planta Med. 1991 Feb;57(1):62-4. doi: 10.1055/s-2006-960020. Planta Med. 1991. PMID: 2062960
The 50% effective dose (ED50) for 7 quassinoids tested against KB ranged from 0.008 microgram/ml for bruceantin, the most cytotoxic of the compounds tested to greater than 5 micrograms/ml for bruceolide, the least toxic tested. The activities of the quassinoids against KB …
The 50% effective dose (ED50) for 7 quassinoids tested against KB ranged from 0.008 microgram/ml for bruceantin, the most cytotoxic of the c …
New semisynthetic quassinoids with in vivo antimalarial activity.
Murakami N, Sugimoto M, Kawanishi M, Tamura S, Kim HS, Begum K, Wataya Y, Kobayashi M. Murakami N, et al. J Med Chem. 2003 Feb 13;46(4):638-41. doi: 10.1021/jm0201971. J Med Chem. 2003. PMID: 12570385
On the basis of a comparative analysis for stability in mouse serum between 15-O-acetylbruceolide and bruceolide 15-methyl carbonate, several 3,15-dialkyl carbonates of bruceolide were synthesized and their in vitro antimalarial activity was assessed. ...
On the basis of a comparative analysis for stability in mouse serum between 15-O-acetylbruceolide and bruceolide 15-methyl carbonate, …
Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice.
Kim HS, Shibata Y, Ko N, Ikemoto N, Ishizuka Y, Murakami N, Sugimoto M, Kobayashi M, Wataya Y. Kim HS, et al. Parasitol Int. 2000 Jan;48(3):271-4. doi: 10.1016/s1383-5769(99)00023-9. Parasitol Int. 2000. PMID: 11227768
The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium berghei in vivo. The concentration of 3,15-di-O-acetylbruceolide required for 50% suppression (ED50) of P. berghei in mice was 0.46 +/- 0.06 mg/k …
The antimalarial activity of the O-acylated bruceolide derivative, 3,15-di-O-acetylbruceolide, was evaluated against Plasmodium bergh …
Synthesis of cytotoxic fluorinated quassinoids.
Ohno N, Fukamiya N, Okano M, Tagahara K, Lee KH. Ohno N, et al. Bioorg Med Chem. 1997 Aug;5(8):1489-95. doi: 10.1016/s0968-0896(97)00095-3. Bioorg Med Chem. 1997. PMID: 9313855
The C-15 senecioyl side chain of brusatol was interchanged with fluorinated acyl groups, and the C-3 hydroxy group of bruceolide was esterified with fluorinated acyl chlorides. These fluorinated quassinoids 11, 12, 13, and 17 showed significant cytotoxic activity against e …
The C-15 senecioyl side chain of brusatol was interchanged with fluorinated acyl groups, and the C-3 hydroxy group of bruceolide was …