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1973 2
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Page 1
Prevalence of Detectable Biotin in Five US Emergency Department Patient Cohorts.
Gunsolus IL, Matias M, Prostko J, Mohr P, Sokoll LJ. Gunsolus IL, et al. Clin Biochem. 2021 Jul;93:26-32. doi: 10.1016/j.clinbiochem.2021.03.009. Epub 2021 Mar 24. Clin Biochem. 2021. PMID: 33771568
Of the 285 positive screens that underwent additional LC-MS/MS testing, 89 (31%) showed detectable biotin, bisnorbiotin, and/or biotin sulfoxide. Biotin, bisnorbiotin, and biotinsulfoxide were detected in 82/89 (92.1%), 61/89 (68.5%), and 18/89 (20.2%) samples, resp …
Of the 285 positive screens that underwent additional LC-MS/MS testing, 89 (31%) showed detectable biotin, bisnorbiotin, and/or bioti …
Advanced analysis of biotin metabolites in body fluids allows a more accurate measurement of biotin bioavailability and metabolism in humans.
Zempleni J, Mock DM. Zempleni J, et al. J Nutr. 1999 Feb;129(2S Suppl):494S-497S. doi: 10.1093/jn/129.2.494S. J Nutr. 1999. PMID: 10064316 Review.
With the use of the HPLC/avidin-binding assay, TLC and derivatization with p-dimethylaminocinnamaldehyde, we have identified and quantitated biotin and metabolites in urine from six healthy adults. Of that total, biotin accounted for 32+/-12%, bisnorbiotin for 52+/-15%, …
With the use of the HPLC/avidin-binding assay, TLC and derivatization with p-dimethylaminocinnamaldehyde, we have identified and quantitated …
Bioavailability of biotin given orally to humans in pharmacologic doses.
Zempleni J, Mock DM. Zempleni J, et al. Am J Clin Nutr. 1999 Mar;69(3):504-8. doi: 10.1093/ajcn/69.3.504. Am J Clin Nutr. 1999. PMID: 10075337 Clinical Trial.
For all 4 doses, biotin accounted for >50% of the total of biotin and biotin metabolites in urine. Bisnorbiotin (13-23%), biotin-d,l-sulfoxide (5-13%), bisnorbiotin methyl ketone (3-9%), and biotin sulfone (1-3%) accounted for the remainder. ...
For all 4 doses, biotin accounted for >50% of the total of biotin and biotin metabolites in urine. Bisnorbiotin (13-23%), biotin-d …
Biotin status: which are valid indicators and how do we know?
Mock DM. Mock DM. J Nutr. 1999 Feb;129(2S Suppl):498S-503S. doi: 10.1093/jn/129.2.498S. J Nutr. 1999. PMID: 10064317 Review.
With the use of improved methods for measuring biotin and metabolites, a recent study indicated that decreased urinary excretion of biotin and bisnorbiotin is an early and sensitive indicator of biotin deficiency, but decreased serum concentration of biotin is not. ...
With the use of improved methods for measuring biotin and metabolites, a recent study indicated that decreased urinary excretion of biotin a …
Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine.
Zempleni J, McCormick DB, Mock DM. Zempleni J, et al. Am J Clin Nutr. 1997 Feb;65(2):508-11. doi: 10.1093/ajcn/65.2.508. Am J Clin Nutr. 1997. PMID: 9022537
Unknown substances 1 and 3 were initially identified as biotin sulfone and bisnorbiotin methyl ketone, respectively, by coelution with authentic standards on HPLC. ...As expected for biotin metabolites, the urinary excretion of biotin sulfone and bisnorbiotin methyl …
Unknown substances 1 and 3 were initially identified as biotin sulfone and bisnorbiotin methyl ketone, respectively, by coelution wit …
Biotin biotransformation to bisnorbiotin is accelerated by several peroxisome proliferators and steroid hormones in rats.
Wang KS, Mock NI, Mock DM. Wang KS, et al. J Nutr. 1997 Nov;127(11):2212-6. doi: 10.1093/jn/127.11.2212. J Nutr. 1997. PMID: 9349849
Bisnorbiotin and biotin sulfoxide are the major catabolites of biotin for humans, swine, and rats. Increased urinary excretion of bisnorbiotin, biotin sulfoxide, or both have been observed during pregnancy and in patients treated with certain anticonvulsants. ...
Bisnorbiotin and biotin sulfoxide are the major catabolites of biotin for humans, swine, and rats. Increased urinary excretion of …
Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
Perry CA, West AA, Gayle A, Lucas LK, Yan J, Jiang X, Malysheva O, Caudill MA. Perry CA, et al. J Nutr. 2014 Dec;144(12):1977-84. doi: 10.3945/jn.114.194472. Epub 2014 Aug 13. J Nutr. 2014. PMID: 25122647 Free PMC article. Clinical Trial.
No differences (P > 0.05) were detected in plasma biotin, urinary biotin, or urinary bisnorbiotin between pregnant and control women. Lactating women excreted 76% more (vs. control; P = 0.001) of the biotin catabolite bisnorbiotin, indicating that lactation accel …
No differences (P > 0.05) were detected in plasma biotin, urinary biotin, or urinary bisnorbiotin between pregnant and control wom …
Smoking accelerates biotin catabolism in women.
Sealey WM, Teague AM, Stratton SL, Mock DM. Sealey WM, et al. Am J Clin Nutr. 2004 Oct;80(4):932-5. doi: 10.1093/ajcn/80.4.932. Am J Clin Nutr. 2004. PMID: 15447901 Free PMC article.
DESIGN: A preliminary study of 7 women and 3 men examined the urinary concentrations of biotin and its metabolites biotin sulfoxide and bisnorbiotin in smokers. The interpretation of the results of this study was limited by the lack of a contemporaneous control group; cons …
DESIGN: A preliminary study of 7 women and 3 men examined the urinary concentrations of biotin and its metabolites biotin sulfoxide and b …
Urinary biotin analogs increase in humans during chronic supplementation: the analogs are biotin metabolites.
Mock DM, Heird GM. Mock DM, et al. Am J Physiol. 1997 Jan;272(1 Pt 1):E83-5. doi: 10.1152/ajpendo.1997.272.1.E83. Am J Physiol. 1997. PMID: 9038855
Bisnorbiotin and biotin sulfoxide excretion increased 85-fold (P < 0.0001) and 114-fold (P < 0.0001), respectively. ...These data provide evidence that the bisnorbiotin and biotin sulfoxide found in human urine are biotin metabolites. ...
Bisnorbiotin and biotin sulfoxide excretion increased 85-fold (P < 0.0001) and 114-fold (P < 0.0001), respectively. ...These da …
The metabolite profile of radioisotope-labeled biotin in rats indicates that rat biotin metabolism is similar to that in humans.
Wang KS, Patel A, Mock DM. Wang KS, et al. J Nutr. 1996 Jul;126(7):1852-7. doi: 10.1093/jn/126.7.1852. J Nutr. 1996. PMID: 8683347
When the dose of [14C]biotin was 30% of the daily dietary intake (a physiologic dose), 50% of the administered 14C was excreted within 24 h; more than half of the excretion was the unchanged vitamin. After d 1, [14C]bisnorbiotin was the major form excreted. For the cumulat …
When the dose of [14C]biotin was 30% of the daily dietary intake (a physiologic dose), 50% of the administered 14C was excreted within 24 h; …
34 results