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Page 1
Nitric oxide is a mediator of hypoxic coronary vasodilatation. Relation to adenosine and cyclooxygenase-derived metabolites.
Park KH, Rubin LE, Gross SS, Levi R. Park KH, et al. Circ Res. 1992 Oct;71(4):992-1001. doi: 10.1161/01.res.71.4.992. Circ Res. 1992. PMID: 1325300
NMA and BW A1433 were more effective in combination than alone (maximum inhibition, approximately 72%). However, irrespective of the concentrations used, there was no synergism among the anti-HCVD effects of NMA, BW A1433, and indomethacin, nor was HCV …
NMA and BW A1433 were more effective in combination than alone (maximum inhibition, approximately 72%). However, irrespective …
Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution.
Linden J, Taylor HE, Robeva AS, Tucker AL, Stehle JH, Rivkees SA, Fink JS, Reppert SM. Linden J, et al. Mol Pharmacol. 1993 Sep;44(3):524-32. Mol Pharmacol. 1993. PMID: 8396714
The potency order of antagonists is 3-(3-iodo-4-aminobenzyl)-8-(4-oxyacetate)phenyl-1- propylxanthine (I-ABOPX) (Ki = 3 nM) > 1,3-dipropyl-8-(4-acrylate)phenylxanthine (BW-A1433) > 1,3-dipropyl-8-sulfophenylxanthine = xanthine amine cogener >> 8-cyclopen …
The potency order of antagonists is 3-(3-iodo-4-aminobenzyl)-8-(4-oxyacetate)phenyl-1- propylxanthine (I-ABOPX) (Ki = 3 nM) > 1,3-dipropy …
Atrioventricular nodal accommodation in isolated guinea pig hearts: physiological significance and role of adenosine.
Jenkins JR, Belardinelli L. Jenkins JR, et al. Circ Res. 1988 Jul;63(1):97-116. doi: 10.1161/01.res.63.1.97. Circ Res. 1988. PMID: 3383386
Beat-by-beat changes in AVN conduction time caused by single- or multiple-step increases in atrial pacing rate were measured during control conditions and in the presence of atropine (1 microM), propranolol (1 microM), and the adenosine antagonist BW-A1433 (1 microM …
Beat-by-beat changes in AVN conduction time caused by single- or multiple-step increases in atrial pacing rate were measured during control …
Antagonism of the effects of adenosine and hypoxia on atrioventricular conduction time by two novel alkylxanthines: correlation with binding to adenosine A1 receptors.
Clemo HF, Bourassa A, Linden J, Belardinelli L. Clemo HF, et al. J Pharmacol Exp Ther. 1987 Aug;242(2):478-84. J Pharmacol Exp Ther. 1987. PMID: 3612546
In four additional hearts, BW A1433U at concentrations of up to 10 microM had no effect on left ventricular pressure or AH interval. BW A1433 or BW A533U (50 microM) inhibited myocardial cyclic AMP phosphodiesterase by only 11.5 +/- 1.6 and 26.6 +/- 2.6%, respective …
In four additional hearts, BW A1433U at concentrations of up to 10 microM had no effect on left ventricular pressure or AH interval. BW …
Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart.
Liu GS, Richards SC, Olsson RA, Mullane K, Walsh RS, Downey JM. Liu GS, et al. Cardiovasc Res. 1994 Jul;28(7):1057-61. doi: 10.1093/cvr/28.7.1057. Cardiovasc Res. 1994. PMID: 7954592
Likewise the potent but unselective A3 receptor antagonist 8-(4-carboxyethenylphenyl)-1,3-dipropylxanthine (BW A1433) completely blocked protection from ischaemic preconditioning. CONCLUSIONS: Because protection against infarction afforded by ischaemic preconditioni …
Likewise the potent but unselective A3 receptor antagonist 8-(4-carboxyethenylphenyl)-1,3-dipropylxanthine (BW A1433) complete …
Role of adenosine in the depolarization of hypoxic hamster diaphragm membrane in vitro.
Esau SA. Esau SA. Am J Respir Crit Care Med. 1994 Apr;149(4 Pt 1):910-4. doi: 10.1164/ajrccm.149.4.8143055. Am J Respir Crit Care Med. 1994. PMID: 8143055
Furthermore, resting membrane potential of hypoxic diaphragm fibers would be repolarized by (1) the removal of adenosine by the enzyme adenosine deaminase (ADA), or (2) the addition of an adenosine antagonist, BW A1433. Adenosine (10(-4) M) depolarized the membrane …
Furthermore, resting membrane potential of hypoxic diaphragm fibers would be repolarized by (1) the removal of adenosine by the enzyme adeno …
Adenosine-induced vasoconstriction in vivo. Role of the mast cell and A3 adenosine receptor.
Shepherd RK, Linden J, Duling BR. Shepherd RK, et al. Circ Res. 1996 Apr;78(4):627-34. doi: 10.1161/01.res.78.4.627. Circ Res. 1996. PMID: 8635220
N6-(3-Iodo-4-aminobenzyl)adenosine (I-ABA), an agonist of A1 and A3 adenosine receptors, produced dose-dependent vasoconstriction. 1,3-Dipropyl-8-(4-acrylate)phenylxanthine (BW-A1433), an antagonist of A1, A2, and A3 receptors, significantly reduced the vasoconstric …
N6-(3-Iodo-4-aminobenzyl)adenosine (I-ABA), an agonist of A1 and A3 adenosine receptors, produced dose-dependent vasoconstriction. 1,3-Dipro …
Targeted deletion of A(3) adenosine receptors improves tolerance to ischemia-reperfusion injury in mouse myocardium.
Cerniway RJ, Yang Z, Jacobson MA, Linden J, Matherne GP. Cerniway RJ, et al. Am J Physiol Heart Circ Physiol. 2001 Oct;281(4):H1751-8. doi: 10.1152/ajpheart.2001.281.4.H1751. Am J Physiol Heart Circ Physiol. 2001. PMID: 11557567 Free article.
Tissue viability assessed by efflux of lactate dehydrogenase was also improved in A(3)AR(-/-) hearts (4.5 +/- 1 vs. 7.5 +/- 1 U/g). The adenosine receptor antagonist BW-A1433 (50 microM) decreased functional recovery following ischemia in A(3)AR(-/-) but not in wild …
Tissue viability assessed by efflux of lactate dehydrogenase was also improved in A(3)AR(-/-) hearts (4.5 +/- 1 vs. 7.5 +/- 1 U/g). The aden …
Arteriolar constriction in skeletal muscle during vascular stunning: role of mast cells.
Keller MW. Keller MW. Am J Physiol. 1997 May;272(5 Pt 2):H2154-63. doi: 10.1152/ajpheart.1997.272.5.H2154. Am J Physiol. 1997. PMID: 9176281
If mast cell granules were depleted by applying compound 48/80 before inducing ischemia, then arterioles failed to constrict during reperfusion. Adenosine A3-antagonist BW-A1433 abolished constriction. These findings suggest that arterioles constrict in reperfusion …
If mast cell granules were depleted by applying compound 48/80 before inducing ischemia, then arterioles failed to constrict during reperfus …
Adenosine acts as an endogenous modulator of IL-2-dependent proliferation of cytotoxic T lymphocytes.
Antonysamy MA, Moticka EJ, Ramkumar V. Antonysamy MA, et al. J Immunol. 1995 Sep 15;155(6):2813-21. J Immunol. 1995. PMID: 7673697
The stimulatory response to R-PIA was attenuated following blockade of ARs by 0.5 mM theophylline and 10 microM BW-A1433, but not by blockade of the A1AR with 100 nM xanthine amine congener. ...
The stimulatory response to R-PIA was attenuated following blockade of ARs by 0.5 mM theophylline and 10 microM BW-A1433, but …
24 results