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Year Number of Results
1995 1
1996 6
1997 2
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2008 2
2024 0

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Page 1
5-Methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4-dione (BA 41899): representative of a novel class of purely calcium-sensitizing agents.
Herold P, Herzig JW, Wenk P, Leutert T, Zbinden P, Fuhrer W, Stutz S, Schenker K, Meier M, Rihs G. Herold P, et al. J Med Chem. 1995 Jul 21;38(15):2946-54. doi: 10.1021/jm00015a017. J Med Chem. 1995. PMID: 7636855
BA 41899 (5-methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5- benzodiazocine-2,4-dione, 6) is a structurally novel 1,5-benzodiazocine derivative and represents the prototype of a hitherto unknown class of positive inotropic Ca(2+)-sensitizing agents. ...CGP 48506 …
BA 41899 (5-methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5- benzodiazocine-2,4-dione, 6) is a structurally novel 1,5-benzo …
Cardiac Ca2+ signaling and Ca2+ sensitizers.
Endoh M. Endoh M. Circ J. 2008 Dec;72(12):1915-25. doi: 10.1253/circj.cj-08-0838. Epub 2008 Nov 4. Circ J. 2008. PMID: 18981594 Free article. Review.
The novel inotropic agent CGP 48506 alters force primarily by Ca(2+)-independent mechanisms in porcine skinned trabeculae.
Palmer S, Di Bello S, Davenport SL, Herzig JW. Palmer S, et al. Cardiovasc Res. 1996 Aug;32(2):411-21. doi: 10.1016/0008-6363(96)00098-3. Cardiovasc Res. 1996. PMID: 8796129
OBJECTIVES: The aim was to determine whether, and by what mechanism(s), a novel inotropic agent 5-methyl-6-phenyl-1,3,5,6-tetrahydro-3, 6-methano-1,5-benzodiazocine-2,4-dione (BA 41899) and its enantiomers directly alter the Ca2+ sensitivity of cardiac myofilaments. …
OBJECTIVES: The aim was to determine whether, and by what mechanism(s), a novel inotropic agent 5-methyl-6-phenyl-1,3,5,6-tetrahydro-3, 6-me …
Non-cyclic AMP-dependent, positive inotropic cyclodepsipeptides with negative chronotropy.
Tsunoo A, Kamijo M. Tsunoo A, et al. J Pharmacol Exp Ther. 1999 Sep;290(3):1006-12. J Pharmacol Exp Ther. 1999. PMID: 10454471
RB, destruxin A, and DB did not affect the half-decay time of relaxation of the papillary muscles, but RC slightly prolonged it, although to a much lesser extent than BA 41899, a calcium sensitizer. This inotropic effect is accompanied by a prolongation of the autom …
RB, destruxin A, and DB did not affect the half-decay time of relaxation of the papillary muscles, but RC slightly prolonged it, although to …
Ca2+ sensitization in idiopathic dilated human myocardium. Differential in vitro effects of (+)-(5-methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazoci ne-2,4-dione, a novel purely Ca2+sensitizing agent, and (+)-5-(1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-meth yl-3, 6-dihydro-2H-1,3,4-thiadiazin-2-one on skinned fibres and isolated ventricular strips.
Herzig JW, Chiesi M, Depersin H, Grüninger S, Hasenfuss G, Kubalek R, Leutert T, Pieske B, Pioch K, Wenk P, Holubarsch C. Herzig JW, et al. Arzneimittelforschung. 1996 Jun;46(6):586-93. Arzneimittelforschung. 1996. PMID: 8767348
22 results