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1989 1
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19 results

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Page 1
Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch.
Bremer RE, Baird EE, Dervan PB. Bremer RE, et al. Chem Biol. 1998 Mar;5(3):119-33. doi: 10.1016/s1074-5521(98)90057-6. Chem Biol. 1998. PMID: 9545429
Polyamides containing N-methylimidazole and N-methylpyrrole amino acids are synthetic ligands that have an affinity and specificity for DNA comparable to many naturally occurring DNA-binding proteins. It has been shown that an eight-ring hairpin polyamide targeted to a spe …
Polyamides containing N-methylimidazole and N-methylpyrrole amino acids are synthetic ligands that have an affinity and specificity for DNA …
Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for p(1)-Arg binding.
Xu Y, Circolo A, Jing H, Wang Y, Narayana SV, Volanakis JE. Xu Y, et al. J Biol Chem. 2000 Jan 7;275(1):378-85. doi: 10.1074/jbc.275.1.378. J Biol Chem. 2000. PMID: 10617628 Free article.
Factor B is a serine protease, which despite its trypsin-like specificity has Asn instead of the typical Asp at the bottom of the S(1) pocket (position 189, chymotrypsinogen numbering). Asp residues are present at positions 187 and 226 and either one could conceivably prov …
Factor B is a serine protease, which despite its trypsin-like specificity has Asn instead of the typical Asp at the bottom of the S(1 …
Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.
Wang B, Mysliwiec T, Krainc D, Jensen RA, Sonoda G, Testa JR, Golemis EA, Kruh GD. Wang B, et al. Oncogene. 1996 May 2;12(9):1921-9. Oncogene. 1996. PMID: 8649853
Arg and c-Abl represent the mammalian members of the Abelson family of nonreceptor protein-tyrosine kinases. To gain insight into the biological role of Arg we used the two-hybrid approach to identify interacting proteins. Using a C-terminal segment of Arg we identi …
Arg and c-Abl represent the mammalian members of the Abelson family of nonreceptor protein-tyrosine kinases. To gain insight into the …
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
Kori S, Shibahashi Y, Ekimoto T, Nishiyama A, Yoshimi S, Yamaguchi K, Nagatoishi S, Ohta M, Tsumoto K, Nakanishi M, Defossez PA, Ikeguchi M, Arita K. Kori S, et al. Bioorg Med Chem. 2021 Dec 15;52:116500. doi: 10.1016/j.bmc.2021.116500. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34801826
An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibitors that target the Arg-binding cavity could potentially repress UHRF1 function in cancer cells. ...Crystal structure of the TT …
An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibito …
Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.
Gorren AC, Schmidt K, Mayer B. Gorren AC, et al. Biochemistry. 2002 Jun 18;41(24):7819-29. doi: 10.1021/bi025675o. Biochemistry. 2002. PMID: 12056914
Imidazole bound to nNOS with a K(d)(app) of 50 microM; tetrahydrobiopterin (BH4) lowered the affinity of nNOS for imidazole 4-fold. The enzyme behaved heterogeneously with respect to Arg binding. Most of nNOS (65-80%) showed competition between Arg and imidazole. In …
Imidazole bound to nNOS with a K(d)(app) of 50 microM; tetrahydrobiopterin (BH4) lowered the affinity of nNOS for imidazole 4-fold. The enzy …
Kinetic Study of Ligand Binding and Conformational Changes in Inducible Nitric Oxide Synthase.
Horn M, Nienhaus K, Nienhaus GU. Horn M, et al. J Phys Chem B. 2018 Dec 13;122(49):11048-11057. doi: 10.1021/acs.jpcb.8b05137. Epub 2018 Jul 18. J Phys Chem B. 2018. PMID: 29965771
The P420 and P450 forms of the enzyme, assigned to a protonated and unprotonated proximal cysteine, through which the heme is anchored to the protein, show markedly different CO rebinding properties. The data suggest that P420 has a widely open distal pocket that admits wa …
The P420 and P450 forms of the enzyme, assigned to a protonated and unprotonated proximal cysteine, through which the heme is anchored to th …
Oligomerization and phosphorylation dependent regulation of ArgBP2 adaptive capabilities and associated functions.
Roignot J, Bonacci T, Ghigo E, Iovanna JL, Soubeyran P. Roignot J, et al. PLoS One. 2014 Jan 27;9(1):e87130. doi: 10.1371/journal.pone.0087130. eCollection 2014. PLoS One. 2014. PMID: 24475245 Free PMC article.
ArgBP2 (Arg-Binding Protein 2/SORBS2) is an adaptor protein involved in cytoskeleton associated signal transduction, thereby regulating cell migration and adhesion. ...In conclusions, we describe a new mechanism of regulation of ArgBP2 where tyrosine p …
ArgBP2 (Arg-Binding Protein 2/SORBS2) is an adaptor protein involved in cytoskeleton associated signal transduct …
Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions.
Paige JS, Jaffrey SR. Paige JS, et al. Curr Top Med Chem. 2007;7(1):97-114. doi: 10.2174/156802607779318253. Curr Top Med Chem. 2007. PMID: 17266598 Review.
In this review, we discuss emerging approaches in the development of isoform-specific NOS-directed therapeutics including dimerization inhibitors, novel L-arginine (L-Arg) binding site inhibitors, and dimer stabilization. Additionally, we suggest novel strategies fo …
In this review, we discuss emerging approaches in the development of isoform-specific NOS-directed therapeutics including dimerization inhib …
A propeptide-independent protease from Tannerella sp.6_1_58FAA_CT1 displays trypsin-like specificity.
Song Q, Zhang X, Li N, Shen J, Cheng J. Song Q, et al. J Basic Microbiol. 2017 Jan;57(1):50-56. doi: 10.1002/jobm.201600486. Epub 2016 Oct 7. J Basic Microbiol. 2017. PMID: 27714828
Despite the absence of any homologs of Tannerella forsythia KLIKK proteases in Tannerella sp.6_1_58FAA_CT1, the strain possesses a putative cysteine protease (G9S4N1) closely related to RgpB of Porphyromonas gingivalis. ...Unlike RgpB, which exclusively cleaves ArgXaa bond …
Despite the absence of any homologs of Tannerella forsythia KLIKK proteases in Tannerella sp.6_1_58FAA_CT1, the strain possesses a pu …
Interaction of human platelets with laminin and identification of the 67 kDa laminin receptor on platelets.
Tandon NN, Holland EA, Kralisz U, Kleinman HK, Robey FA, Jamieson GA. Tandon NN, et al. Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):535-42. doi: 10.1042/bj2740535. Biochem J. 1991. PMID: 1826081 Free PMC article.
The adhesion of platelets to laminin was inhibited by two monoclonal IgM antibodies specific to the LR-1 domain of the 67 kDa receptor. The binding protein was surface-oriented, as shown by flow cytofluorimetry and by the fact that it could be iodinated in intact pl …
The adhesion of platelets to laminin was inhibited by two monoclonal IgM antibodies specific to the LR-1 domain of the 67 kDa recepto …
19 results