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Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells.
Liu Y, Liu X, Wang H, Ding P, Wang C. Liu Y, et al. Phytomedicine. 2022 Jul;101:154102. doi: 10.1016/j.phymed.2022.154102. Epub 2022 Apr 21. Phytomedicine. 2022. PMID: 35526323
The effects of agrimonolide on the SKOV-3 xenograft model were also studied. RESULTS: Agrimonolide dose-dependently inhibited proliferation, migration, and invasion and promoted apoptosis in A2780 and SKOV-3 cells. ...Agrimonolide may be a novel therapeutic a …
The effects of agrimonolide on the SKOV-3 xenograft model were also studied. RESULTS: Agrimonolide dose-dependently inhibited …
Isolation of Isocoumarins and Flavonoids as α-Glucosidase Inhibitors from Agrimonia pilosa L.
Park MJ, Kang YH. Park MJ, et al. Molecules. 2020 May 31;25(11):2572. doi: 10.3390/molecules25112572. Molecules. 2020. PMID: 32486502 Free PMC article.
The phytochemical study of AP based on AGI activity led to the isolation of four isocoumarins; agrimonolide (1), agrimonolide-6-O-beta-d-glucopyranoside (2), desmethylagrimonolide (3), desmethylagrimonolide-6-O-beta-d-glucopyranoside (4), and four flavonoids; luteol …
The phytochemical study of AP based on AGI activity led to the isolation of four isocoumarins; agrimonolide (1), agrimonolide- …
Current Progress and Outlook for Agrimonolide: A Promising Bioactive Compound from Agrimonia pilosa Ledeb.
Huang T, Zhao CC, Xue M, Cao YF, Chen LK, Chen JX, Sun YJ, Zeng J. Huang T, et al. Pharmaceuticals (Basel). 2023 Jan 19;16(2):150. doi: 10.3390/ph16020150. Pharmaceuticals (Basel). 2023. PMID: 37259301 Free PMC article. Review.
Agrimonolide (AM), which is a derivative of isocoumarins, is found mainly in the herb Agrimonia pilosa Ledeb. ...
Agrimonolide (AM), which is a derivative of isocoumarins, is found mainly in the herb Agrimonia pilosa Ledeb. ...
Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation.
Chen L, Teng H, Zhang KY, Skalicka-Woźniak K, Georgiev MI, Xiao J. Chen L, et al. Front Pharmacol. 2017 Jan 11;7:513. doi: 10.3389/fphar.2016.00513. eCollection 2016. Front Pharmacol. 2017. PMID: 28119605 Free PMC article.
Agrimonolide and desmethylagrimonolide are the main bioactive polyphenols in agrimony with well-documented antioxidant, anti-diabetic, and anti-inflammatory potential. ...Agrimonolide and desmethylagrimonolide also possess considerable protective activity from oxida …
Agrimonolide and desmethylagrimonolide are the main bioactive polyphenols in agrimony with well-documented antioxidant, anti-diabetic …
Protective effects of agrimonolide on hypoxia-induced H9c2 cell injury by maintaining mitochondrial homeostasis.
Wang C, Qi C, Liu M, Wang L, Cheng G, Li L, Xing Y, Zhao X, Liu J. Wang C, et al. J Cell Biochem. 2022 Feb;123(2):306-321. doi: 10.1002/jcb.30169. Epub 2021 Nov 1. J Cell Biochem. 2022. PMID: 34724244
Cardiomyocyte death caused by hypoxia is one of the main causes of myocardial infarction or heart failure, and mitochondria play an important role in this process. Agrimonolide (AM) is a monomeric component extracted from Agrimonia pilosa L. and has antioxidant, antitumor, …
Cardiomyocyte death caused by hypoxia is one of the main causes of myocardial infarction or heart failure, and mitochondria play an importan …
Lawsonia inermis flower aqueous extract expressed better anti-alpha-glucosidase and anti-acetylcholinesterase activity and their molecular dynamics.
Shahanaj I, Ramakrishnan J, Poomani K, Devarajan N. Shahanaj I, et al. J Biomol Struct Dyn. 2023;41(23):13752-13765. doi: 10.1080/07391102.2023.2179546. Epub 2023 Mar 11. J Biomol Struct Dyn. 2023. PMID: 36905654
Molecular dynamics simulation for 100 ns showed the stable binding of top two ligand/enzyme complexes with lowest binding energy such as 1,2,3,6-Tetrakis-O-galloyl-beta-D-glucose (TGBG)/human alpha-glucosidase, Kaempferol 3-glucoside-7-rhamnoside (KGR)/alpha-glucosidase, agrim …
Molecular dynamics simulation for 100 ns showed the stable binding of top two ligand/enzyme complexes with lowest binding energy such as 1,2 …
Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-kappaB in lipopolysaccharide-stimulated macrophages.
Chen L, Teng H, Fang T, Xiao J. Chen L, et al. Phytomedicine. 2016 Jul 15;23(8):846-55. doi: 10.1016/j.phymed.2016.03.016. Epub 2016 Apr 22. Phytomedicine. 2016. PMID: 27288920
HYPOTHESIS/PURPOSE: To investigate the mechanism of anti-inflammatory activity of agrimonolide. STUDY DESIGN: Anti-inflammatory activity of agrimonolide in cells was applied. METHODS: Anti-inflammatory activity of agrimonolide isolated from Agrimonia pilosa w …
HYPOTHESIS/PURPOSE: To investigate the mechanism of anti-inflammatory activity of agrimonolide. STUDY DESIGN: Anti-inflammatory activ …
Elucidating the Mechanism of Agrimonolide in Treating Colon Cancer Based on Network Pharmacology.
Yu L, Gai Y. Yu L, et al. Drug Des Devel Ther. 2023 Jul 27;17:2209-2222. doi: 10.2147/DDDT.S409530. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 37533972 Free PMC article.
PURPOSE: This study reported the efficacy and underlying mechanism of agrimonolide (AM) in treating colon cancer. METHODS: Colon cancer-AM-related targets were screened from online database. ...
PURPOSE: This study reported the efficacy and underlying mechanism of agrimonolide (AM) in treating colon cancer. METHODS: Colon canc …
The anti-colorectal cancer effect and metabolites of Agrimonia pilosa Ledeb.
Wang L, Chen Q, Song H, Xing W, Shi J, Li Y, Lv Y, Wang Z, Chen J, Zhao W. Wang L, et al. J Ethnopharmacol. 2024 Apr 9;329:118146. doi: 10.1016/j.jep.2024.118146. Online ahead of print. J Ethnopharmacol. 2024. PMID: 38604512 Free article.
The administration of the extract adjusted the composition of gut microbiota and its components Agrimoniin and Agrimonolide-6-o-glucoside showed the strongest anti-CRC effect in vivo with adjusting the gut microbiota differently. ...Besides, the metabolites of extract from …
The administration of the extract adjusted the composition of gut microbiota and its components Agrimoniin and Agrimonolide-6-o-gluco …
Preparative purification of five bioactive components from Agrimonia pilosa Ledeb by high-speed counter-current chromatography.
Wang Y, Liu M, Zheng L, Yin L, Xu L, Qi Y, Ma X, Liu K, Peng J. Wang Y, et al. J Sep Sci. 2012 Aug;35(15):1977-84. doi: 10.1002/jssc.201200011. J Sep Sci. 2012. PMID: 22865760
Five chemicals including taxifolin-3-glucoside (6.4 mg), quercetin-3-rhamnoside (13.0 mg), tiliroside (14.7 mg), agrimonolide (21.4 mg), and tormentic acid (29.8 mg) with the purities of 94.24, 95.37, 97.42, 95.29, and 96.34% were separated from each 200 mg prepared fracti …
Five chemicals including taxifolin-3-glucoside (6.4 mg), quercetin-3-rhamnoside (13.0 mg), tiliroside (14.7 mg), agrimonolide (21.4 m …
18 results