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Year | Number of Results |
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2003 | 1 |
2004 | 1 |
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Tyrphostin AGL-2043 eluting stent reduces neointima formation in porcine coronary arteries.
Cardiovasc Res. 2004 Oct 1;64(1):165-71. doi: 10.1016/j.cardiores.2004.06.013.
Cardiovasc Res. 2004.
PMID: 15364624
OBJECTIVE: Tyrphostin AGL-2043 is a potent tricyclic quinoxaline inhibitor of PDGF beta-receptor tyrosine kinase (PTK), Kit, and Flt3. ...Tissue concentration in segments 1 cm proximal and distal to the stents, were negligible or zero at 1 h, 24 h, and 4 week …
OBJECTIVE: Tyrphostin AGL-2043 is a potent tricyclic quinoxaline inhibitor of PDGF beta-receptor tyrosine kinase (PTK), …
Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries.
Banai S, Chorny M, Gertz SD, Fishbein I, Gao J, Perez L, Lazarovichi G, Gazit A, Levitzki A, Golomb G.
Banai S, et al.
Biomaterials. 2005 Feb;26(4):451-61. doi: 10.1016/j.biomaterials.2004.02.040.
Biomaterials. 2005.
PMID: 15275819
Local delivery of antiproliferative drugs encapsulated in biodegradable nanoparticles (NP) has shown promise as an experimental strategy for preventing restenosis development. A novel PDGFRbeta-specific tyrphostin, AGL-2043, was formulated in polylactide-base …
Local delivery of antiproliferative drugs encapsulated in biodegradable nanoparticles (NP) has shown promise as an experimental strategy for …
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Recent Advances in Manufacturing Innovative Stents.
Beshchasna N, Saqib M, Kraskiewicz H, Wasyluk Ł, Kuzmin O, Duta OC, Ficai D, Ghizdavet Z, Marin A, Ficai A, Sun Z, Pichugin VF, Opitz J, Andronescu E.
Beshchasna N, et al.
Pharmaceutics. 2020 Apr 13;12(4):349. doi: 10.3390/pharmaceutics12040349.
Pharmaceutics. 2020.
PMID: 32294908
Free PMC article.
Review.
DES were developed to reduce the tissue hyperplasia and in-stent restenosis utilizing antiproliferative substances like paclitaxel, limus (siro-, zotaro-, evero-, bio-, amphi-, tacro-limus), ABT-578, tyrphostin AGL-2043, genes, etc. The innovative solutions a …
DES were developed to reduce the tissue hyperplasia and in-stent restenosis utilizing antiproliferative substances like paclitaxel, limus (s …
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Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit.
Gazit A, Yee K, Uecker A, Böhmer FD, Sjöblom T, Ostman A, Waltenberger J, Golomb G, Banai S, Heinrich MC, Levitzki A.
Gazit A, et al.
Bioorg Med Chem. 2003 May 1;11(9):2007-18. doi: 10.1016/s0968-0896(03)00048-8.
Bioorg Med Chem. 2003.
PMID: 12670652
Four of the highly active compounds were characterized in detail and are shown to inhibit PDGFR kinase activity of the isolated receptor as well as in intact cells in the sub-micromolar concentration range. We show that the most active inhibitor (compound 13, AGL 2043 …
Four of the highly active compounds were characterized in detail and are shown to inhibit PDGFR kinase activity of the isolated receptor as …
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