Syntheses and antitumor activities of 7-O-(3-amino-2,3,6-trideoxy-2-fluoro-alpha-L-talopyranosyl)daunomvcinone and -adriamycinone

J Antibiot (Tokyo). 1989 Aug;42(8):1315-7. doi: 10.7164/antibiotics.42.1315.

Authors

Y Takagi¹, H Park, T Tsuchiya, S Umezawa, T Takeuchi, K Komuro, C Nosaka

Affiliation

¹ Institute of Bioorganic Chemistry, Kanagawa, Japan.

PMID: 2759914
DOI: 10.7164/antibiotics.42.1315

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Division / drug effects
Daunorubicin / analogs & derivatives*
Daunorubicin / chemical synthesis
Daunorubicin / pharmacology
Daunorubicin / therapeutic use
Doxorubicin / analogs & derivatives*
Doxorubicin / chemical synthesis
Doxorubicin / pharmacology
Doxorubicin / therapeutic use
Leukemia L1210 / drug therapy
Mice
Tumor Cells, Cultured / drug effects

Substances

7(O)-(3-amino-2,3,6-trideoxy-2-fluorotalopyranosyl)adriamycinone
7-O-(3-amino-2,3,6-trideoxy-2-fluorotalopyranosyl)daunomycinone
Doxorubicin
Daunorubicin