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1980 1
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1983 3
1986 2
1987 2
2024 0

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Page 1
Comparative pharmacokinetics and metabolism of doxorubicin and 4-demethoxy-4'-O-methyldoxorubicin in tumor-bearing mice.
Formelli F, Carsana R, Pollini C. Formelli F, et al. Cancer Chemother Pharmacol. 1986;16(1):15-21. doi: 10.1007/BF00255280. Cancer Chemother Pharmacol. 1986. PMID: 3753554
It has been reported that 4-demethoxy-4'-O-methyldoxorubicin (4-dm-4'-O-methylDX) is more potent than doxorubicin (DX), equally active in some murine leukemias and solid tumors, and almost devoid of cardiotoxicity. ...
It has been reported that 4-demethoxy-4'-O-methyldoxorubicin (4-dm-4'-O-methylDX) is more potent than doxorubicin (DX), …
New doxorubicin analogs active against doxorubicin-resistant colon tumor xenografts in the nude mouse.
Giuliani FC, Kaplan NO. Giuliani FC, et al. Cancer Res. 1980 Dec;40(12):4682-7. Cancer Res. 1980. PMID: 7438099
The drugs tested were: 4'-epidoxorubicin; 4'-deoxydoxorubicin; and 4'-O-methyldoxorubicin. Mice were treated i.v. on a weekly basis for 3 to 4 weeks, starting when the tumors were well established (advanced stage of tumor treatment). ...The results of these s …
The drugs tested were: 4'-epidoxorubicin; 4'-deoxydoxorubicin; and 4'-O-methyldoxorubicin. Mice were treated i.v. on a …
Cross resistance and cellular uptake of 4'-O-methyldoxorubicin in experimental tumors with acquired resistance to doxorubicin.
Di Marco A, Skovsgaard T, Casazza AM, Pratesi G, Nissen NI, Danø K. Di Marco A, et al. Cancer Chemother Pharmacol. 1981;7(1):15-20. doi: 10.1007/BF00258207. Cancer Chemother Pharmacol. 1981. PMID: 7340984
A new analog of doxorubicin, 4'-O-methyldoxorubicin, was previously reported to have a pronounced activity against L1210 leukemia, which shows a natural partial resistance to doxorubicin itself. In the present study, lines of P388 leukemia and Ehrlich ascites …
A new analog of doxorubicin, 4'-O-methyldoxorubicin, was previously reported to have a pronounced activity against L121 …
Synthesis, antitumor activity, and cardiac toxicity of new 4-demethoxyanthracyclines.
Penco S, Casazza AM, Franchi G, Barbieri B, Bellini O, Podestà A, Savi G, Pratesi G, Geroni C, Di Marco A, Arcamone F. Penco S, et al. Cancer Treat Rep. 1983 Jul-Aug;67(7-8):665-73. Cancer Treat Rep. 1983. PMID: 6575865
In a parallel activity-cardiotoxicity test in C3H mice repeatedly treated iv, 4-demethoxydoxorubicin, 4-demethoxy-4'-epidoxorubicin, 4-demethoxy-4'-O-methyldoxorubicin, and 4-demethoxy-4'-deoxydoxorubicin showed antitumor activity against mammary carcinoma wi …
In a parallel activity-cardiotoxicity test in C3H mice repeatedly treated iv, 4-demethoxydoxorubicin, 4-demethoxy-4'-epidoxorubicin, 4-demet …
In vitro responses of nude mouse-xenografted human colon carcinomas exposed to doxorubicin derivatives in tissue culture and in the mouse.
Zirvi KA, van der Bosch J, Kaplan NO. Zirvi KA, et al. Cancer Res. 1982 Sep;42(9):3793-7. Cancer Res. 1982. PMID: 7105044
Both of the pretreatments produced very similar decreases in drug responsiveness to all of the doxorubicin derivatives tested (4'-deoxydoxorubicin, 4'-O-methyldoxorubicin, 4'-epidoxorubicin, 4-demethoxydoxorubicin, and N-trifluoroacetyldoxorubicin-14-valeriat …
Both of the pretreatments produced very similar decreases in drug responsiveness to all of the doxorubicin derivatives tested (4'-deoxydoxor …
Correlation of drug sensitivity on human colon adenocarcinoma cells grown in soft agar and in athymic mice.
Zirvi KA, Masui H, Giuliani FC, Kaplan NO. Zirvi KA, et al. Int J Cancer. 1983 Jul 15;32(1):45-51. doi: 10.1002/ijc.2910320108. Int J Cancer. 1983. PMID: 6862693
In the 1 h drug exposure experiments six drugs, doxorubicin (DX), 4'-deoxydoxorubicin (deoDX), 4'epidoxorubicin(epiDX), 4'-O-methyldoxorubicin (O-DX), N-trifluoroacetyldoxorubicin-14-valerate (AD-32) and 5-fluorouracil (FUra) were studied, while in continuous …
In the 1 h drug exposure experiments six drugs, doxorubicin (DX), 4'-deoxydoxorubicin (deoDX), 4'epidoxorubicin(epiDX), 4'-O- …
Synthesis, biological and biochemical properties of new anthracyclines modified in the aminosugar moiety.
Bargiotti A, Casazza AM, Cassinelli G, Di Marco A, Penco S, Pratesi G, Supino R, Zaccara A, Zunino F, Arcamone F. Bargiotti A, et al. Cancer Chemother Pharmacol. 1983;10(2):84-9. doi: 10.1007/BF00446215. Cancer Chemother Pharmacol. 1983. PMID: 6831630
In general all the compounds retained a remarkable antitumor activity at their optimal doses. The most active compound against P388 leukemia was 4'-O-methyldoxorubicin, which was also more active than doxorubicin against L1210 leukemia....
In general all the compounds retained a remarkable antitumor activity at their optimal doses. The most active compound against P388 leukemia …
Preliminary evaluation of treatment and selection conditions which affect expression of anthracycline mutagenicity in Salmonella typhimurium and a diploid human lymphoblast cell line.
Thomas HF. Thomas HF. J Appl Toxicol. 1987 Dec;7(6):403-10. doi: 10.1002/jat.2550070610. J Appl Toxicol. 1987. PMID: 3323285
A 20 min preincubation treatment version of the Ames test using a 0.2-2.0 microgram/ml (0.36-3.60 nM/ml) dose range of each of the anthracyclines Adriamycin, Daunomycin, Carminomycin, 4'-O-methyldoxorubicin and 4-demethoxydoxorubicin confirmed the order of mu …
A 20 min preincubation treatment version of the Ames test using a 0.2-2.0 microgram/ml (0.36-3.60 nM/ml) dose range of each of the anthracyc …
Activity of cancer chemotherapeutic agents against human colorectal carcinomas grown as primary tissue culture.
Zirvi KA, van der Bosch J, Masui H, Kaplan NO, Hill GJ. Zirvi KA, et al. J Cancer Res Clin Oncol. 1987;113(1):20-6. doi: 10.1007/BF00389962. J Cancer Res Clin Oncol. 1987. PMID: 3818775
In drug-response studies with cultures from a colon tumor biopsy all four drugs studied (4'-deoxydoxorubicin, 4'-O-methyldoxorubicin, 5-fluorouracil, and 1,3-bis-[chloroethyl]-1-nitrosourea) inhibited growth of the cells within 3-6 days after drug treatment. …
In drug-response studies with cultures from a colon tumor biopsy all four drugs studied (4'-deoxydoxorubicin, 4'-O-methyldo
12 results