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FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.
Chen D, Zhang L, Pang B, Chen J, Xu Z, Abe I, Liu W. Chen D, et al. J Bacteriol. 2013 May;195(9):1931-9. doi: 10.1128/JB.00033-13. Epub 2013 Feb 22. J Bacteriol. 2013. PMID: 23435975 Free PMC article.
Taking previously reported bioassay results regarding the intermediates 9-deoxo-31-O-demethyl-FK506 and 31-O-demethyl-FK506 into account, it is clear that the modifications catalyzed by FkbD and FkbM are of importance to rea …
Taking previously reported bioassay results regarding the intermediates 9-deoxo-31-O-demethyl-FK506 and 31 …
In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates.
Lee Y, Lee KT, Lee SJ, Beom JY, Hwangbo A, Jung JA, Song MC, Yoo YJ, Kang SH, Averette AF, Heitman J, Yoon YJ, Cheong E, Bahn YS. Lee Y, et al. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01627-18. doi: 10.1128/AAC.01627-18. Print 2018 Nov. Antimicrob Agents Chemother. 2018. PMID: 30181374 Free PMC article.
In this study, we analyzed the cytotoxicity, immunosuppressive activity, and antifungal activity of four FK506 analogs, 31-O-demethyl-FK506, 9-deoxo-FK506, 9-deoxo-31-O-demethyl-FK506, and 9-deoxo-prolyl-FK506, in comparison …
In this study, we analyzed the cytotoxicity, immunosuppressive activity, and antifungal activity of four FK506 analogs, 31-O- …
Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR. Motamedi H, et al. J Bacteriol. 1996 Sep;178(17):5243-8. doi: 10.1128/jb.178.17.5243-5248.1996. J Bacteriol. 1996. PMID: 8752344 Free PMC article.
FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive and antifungal activities. The gene encoding 31-O-demethyl-FK506 methyltransferase, fkbM, was isolated from Streptomyces sp. strains MA6858 and MA6548, two FK506 prod …
FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive and antifungal activities. The gene encoding 31 …