Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.
Stephens CE, Tanious F, Kim S, Wilson WD, Schell WA, Perfect JR, Franzblau SG, Boykin DW.
Stephens CE, et al.
J Med Chem. 2001 May 24;44(11):1741-8. doi: 10.1021/jm000413a.
J Med Chem. 2001.
PMID: 11356109
The binding affinities are highly dependent on structure and are significantly affected by substituents both on the phenyl rings of the 2,5-diphenylfuran nucleus and on the cationic centers. Of the 17 novel dicationic compounds synthesized, six (6a, 6b, 5b, 6 …
The binding affinities are highly dependent on structure and are significantly affected by substituents both on the phenyl rings of the 2 …