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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1969 1
1971 2
1972 2
1973 2
1975 3
1976 4
1977 1
1978 3
1979 5
1980 3
1981 4
1982 7
1983 1
1984 3
1985 4
1986 6
1987 4
1988 3
1989 2
1990 1
1991 3
1992 5
1993 4
1995 5
1996 1
1997 3
1998 2
1999 5
2000 3
2001 4
2002 1
2003 4
2004 3
2005 6
2006 4
2007 2
2008 2
2009 6
2010 4
2011 3
2012 1
2013 2
2014 6
2015 7
2016 19
2017 21
2018 16
2019 33
2020 33
2021 26
2022 35
2023 26
2024 11

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338 results

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Page 1
N(1)-methyladenosine modification in cancer biology: Current status and future perspectives.
Li J, Zhang H, Wang H. Li J, et al. Comput Struct Biotechnol J. 2022 Nov 25;20:6578-6585. doi: 10.1016/j.csbj.2022.11.045. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36467585 Free PMC article. Review.
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N(1)-methyladenosine (m(1)A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and long non-c …
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N(1)-methyladenosine (m(1)A), wh …
Post-transcriptional gene regulation by mRNA modifications.
Zhao BS, Roundtree IA, He C. Zhao BS, et al. Nat Rev Mol Cell Biol. 2017 Jan;18(1):31-42. doi: 10.1038/nrm.2016.132. Epub 2016 Nov 3. Nat Rev Mol Cell Biol. 2017. PMID: 27808276 Free PMC article. Review.
N(6)-adenosine methylation directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in processes such as cell differentiation, embryonic development and stress responses. Other mRNA modifications, including N(1)-methyladenosine …
N(6)-adenosine methylation directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in processes …
The epitranscriptome beyond m6A.
Wiener D, Schwartz S. Wiener D, et al. Nat Rev Genet. 2021 Feb;22(2):119-131. doi: 10.1038/s41576-020-00295-8. Epub 2020 Nov 13. Nat Rev Genet. 2021. PMID: 33188361 Review.
Here, we review our knowledge regarding the detection, distribution, abundance, biogenesis, functions and possible mechanisms of action of six of these modifications - pseudouridine (psi), 5-methylcytidine (m(5)C), N (1)-methyladenosine (m(1)A), N (4)-acetylcytidine …
Here, we review our knowledge regarding the detection, distribution, abundance, biogenesis, functions and possible mechanisms of action of s …
N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z. Wang Y, et al. Nat Commun. 2021 Nov 2;12(1):6314. doi: 10.1038/s41467-021-26718-6. Nat Commun. 2021. PMID: 34728628 Free PMC article.
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is characterized by high recurrence and heterogeneity, yet its mechanism is not well understood. Here we show that N(1)-methyladenosine methylation (m(1)A) in tRNA is remarkably el …
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is characterized by high recurrence and heterogeneity, …
Regulation and functions of non-m6A mRNA modifications.
Sun H, Li K, Liu C, Yi C. Sun H, et al. Nat Rev Mol Cell Biol. 2023 Oct;24(10):714-731. doi: 10.1038/s41580-023-00622-x. Epub 2023 Jun 27. Nat Rev Mol Cell Biol. 2023. PMID: 37369853 Review.
In this Review, we focus on the regulation and function of non-m(6)A modifications in eukaryotic mRNA, including pseudouridine (psi), N(6),2'-O-dimethyladenosine (m(6)Am), N(1)-methyladenosine (m(1)A), inosine, 5-methylcytidine (m(5)C), N(4)-acetylcytidine (ac(4)C), …
In this Review, we focus on the regulation and function of non-m(6)A modifications in eukaryotic mRNA, including pseudouridine (psi), N(6),2 …
RNA modifications: importance in immune cell biology and related diseases.
Cui L, Ma R, Cai J, Guo C, Chen Z, Yao L, Wang Y, Fan R, Wang X, Shi Y. Cui L, et al. Signal Transduct Target Ther. 2022 Sep 22;7(1):334. doi: 10.1038/s41392-022-01175-9. Signal Transduct Target Ther. 2022. PMID: 36138023 Free PMC article. Review.
In this review, we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications, including N(6)-methyladenosine (m(6)A), 5-methylcytosine (m(5)C), N(1)-methyladenosine (m(1)A), N(7)-methylguanosine (m(7)G), N(4)-acetylcytosin …
In this review, we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications, including N(6)-met …
ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C. Liu F, et al. Cell. 2016 Oct 20;167(3):816-828.e16. doi: 10.1016/j.cell.2016.09.038. Epub 2016 Oct 13. Cell. 2016. PMID: 27745969 Free PMC article.
Here, we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N(1)-methyladenosine (m(1)A) in tRNAs. The ALKBH1-catalyzed demethylation of the target tRNAs results in attenuated translation initiation and decreased usage of tRNAs in pro …
Here, we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N(1)-methyladenosine (m(1)A) in tR …
RNA m1A methylation regulates glycolysis of cancer cells through modulating ATP5D.
Wu Y, Chen Z, Xie G, Zhang H, Wang Z, Zhou J, Chen F, Li J, Chen L, Niu H, Wang H. Wu Y, et al. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2119038119. doi: 10.1073/pnas.2119038119. Epub 2022 Jul 8. Proc Natl Acad Sci U S A. 2022. PMID: 35867754 Free PMC article.
Studies on biological functions of RNA modifications such as N(6)-methyladenosine (m(6)A) in mRNA have sprung up in recent years, while the roles of N(1)-methyladenosine (m(1)A) in cancer progression remain largely unknown. ...
Studies on biological functions of RNA modifications such as N(6)-methyladenosine (m(6)A) in mRNA have sprung up in recent years, while the …
Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts.
Li X, Xiong X, Zhang M, Wang K, Chen Y, Zhou J, Mao Y, Lv J, Yi D, Chen XW, Wang C, Qian SB, Yi C. Li X, et al. Mol Cell. 2017 Dec 7;68(5):993-1005.e9. doi: 10.1016/j.molcel.2017.10.019. Epub 2017 Nov 5. Mol Cell. 2017. PMID: 29107537 Free PMC article.
Gene expression can be post-transcriptionally regulated via dynamic and reversible RNA modifications. N(1)-methyladenosine (m(1)A) is a recently identified mRNA modification; however, little is known about its precise location and biogenesis. ...
Gene expression can be post-transcriptionally regulated via dynamic and reversible RNA modifications. N(1)-methyladenosine (m( …
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer.
Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A. Su Z, et al. Nat Commun. 2022 Apr 20;13(1):2165. doi: 10.1038/s41467-022-29790-8. Nat Commun. 2022. PMID: 35444240 Free PMC article.
However, most genome-wide mapping of RNA modifications has focused on messenger RNAs and transfer RNAs, but such datasets have been lacking for small RNAs. Here we mapped N(1)-methyladenosine (m(1)A) in the cellular small RNA space. Benchmarked with synthetic m(1)A …
However, most genome-wide mapping of RNA modifications has focused on messenger RNAs and transfer RNAs, but such datasets have been lacking …
338 results