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Page 1
A synthetic study toward the core structure of (-)-apicularen A.
Pradhan TR, Mohapatra DK. Pradhan TR, et al. Org Biomol Chem. 2018 Nov 21;16(45):8810-8818. doi: 10.1039/c8ob02301h. Org Biomol Chem. 2018. PMID: 30403225
A concise synthetic strategy towards the core structure of (-)-apicularen A has been described in an 11-step synthetic sequence from a known intermediate. ...
A concise synthetic strategy towards the core structure of (-)-apicularen A has been described in an 11-step synthetic sequenc …
Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells.
Seo KS, Kim H, Hong TH, Kim JS, Song KS, Yun EJ, Park JH, Jung YH, Park JI, Kweon GR, Yoon WH, Lim K, Hwang BD. Seo KS, et al. Biochem Biophys Res Commun. 2013 May 10;434(3):634-40. doi: 10.1016/j.bbrc.2013.03.133. Epub 2013 Apr 10. Biochem Biophys Res Commun. 2013. PMID: 23583412
Apicularen A is a novel antitumor agent and strongly induces death in tumor cells. In this study, we synthesized apicularen A acetate, an acetyl derivative of apicularen A, and investigated its antitumor effect and mechanism in HM7 colon …
Apicularen A is a novel antitumor agent and strongly induces death in tumor cells. In this study, we synthesized apicularen …
Correction: A synthetic study toward the core structure of (-)-apicularen A.
Pradhan TR, Mohapatra DK. Pradhan TR, et al. Org Biomol Chem. 2019 Jan 2;17(2):397. doi: 10.1039/c8ob90184h. Org Biomol Chem. 2019. PMID: 30520924
Correction for 'A synthetic study toward the core structure of (-)-apicularen A' by Tapas R. Pradhan et al., Org. Biomol. Chem., 2018, 16, 8810-8818....
Correction for 'A synthetic study toward the core structure of (-)-apicularen A' by Tapas R. Pradhan et al., Org. Biomol. Chem …
Total synthesis of (-)-apicularen A.
Palimkar SS, Uenishi J. Palimkar SS, et al. Org Lett. 2010 Sep 17;12(18):4160-3. doi: 10.1021/ol101753y. Org Lett. 2010. PMID: 20707358
A convergent total synthesis of (-)-apicularen A, a highly cytostatic 12-membered macrolide, has been accomplished. ...
A convergent total synthesis of (-)-apicularen A, a highly cytostatic 12-membered macrolide, has been accomplished. ...
Apicularen A induces cell death through Fas ligand up-regulation and microtubule disruption by tubulin down-regulation in HM7 human colon cancer cells.
Kim JS, Lee YC, Nam HT, Li G, Yun EJ, Song KS, Seo KS, Park JH, Ahn JW, Zee O, Park JI, Yoon WH, Lim K, Hwang BD. Kim JS, et al. Clin Cancer Res. 2007 Nov 1;13(21):6509-17. doi: 10.1158/1078-0432.CCR-07-1428. Clin Cancer Res. 2007. PMID: 17975164
However, the mechanisms of apicularen A-induced cell death and in vivo effects remain unclear. ...Moreover, apicularen A reduced liver colonization as much as 95.6% (50 microg/kg/d). ...
However, the mechanisms of apicularen A-induced cell death and in vivo effects remain unclear. ...Moreover, apicularen …
PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells.
Seo KS, Kim JS, Park JH, Song KS, Yun EJ, Park JI, Kweon GR, Yoon WH, Lim K, Hwang BD. Seo KS, et al. BMC Cancer. 2014 Jan 22;14:36. doi: 10.1186/1471-2407-14-36. BMC Cancer. 2014. PMID: 24447339 Free PMC article.
RESULTS: We found that apicularen A induced caspase-dependent apoptosis in HeLa cells. PMA synergistically increased cytotoxicity and apoptotic sub-G1 population induced by apicularen A. ...RNA interference using siRNA against PKCalpha, but not PKCbeta …
RESULTS: We found that apicularen A induced caspase-dependent apoptosis in HeLa cells. PMA synergistically increased cytotoxic …
Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60.
Hong J, Ishihara K, Zee O, Ohuchi K. Hong J, et al. Planta Med. 2005 Apr;71(4):306-12. doi: 10.1055/s-2005-864095. Planta Med. 2005. PMID: 15856405
In contrast, apicularen B, an N-acetylglucosamine glycoside of apicularen A, had no such effects at 100 nM. These findings indicated that apicularen A induces apoptosis in HL-60 cells by activating caspases. Phosphorylation of p44/42 MAPK, p38 MAPK and …
In contrast, apicularen B, an N-acetylglucosamine glycoside of apicularen A, had no such effects at 100 nM. These findings ind …
Total synthesis and biological evaluation of (-)-apicularen A and its analogues.
Palimkar SS, Uenishi J, Ii H. Palimkar SS, et al. J Org Chem. 2012 Jan 6;77(1):388-99. doi: 10.1021/jo2019762. Epub 2011 Dec 6. J Org Chem. 2012. PMID: 22118352
The total synthesis of (-)-apicularen A (1), a highly cytostatic 12-membered macrolide, and its analogues is described. ...Analogues of C11-epi-, C11-deoxy-C10-alpha-hydroxy-, and C10-C11 dehydrated apicularen A 3-5 were also prepared. Cytostatic activ …
The total synthesis of (-)-apicularen A (1), a highly cytostatic 12-membered macrolide, and its analogues is described. ...Ana …
A formal total synthesis of (+)-apicularen A: base-induced conversion of apicularen-derived intermediates into salicylihalamide-like products.
Lewis A, Stefanuti I, Swain SA, Smith SA, Taylor RJ. Lewis A, et al. Org Biomol Chem. 2003 Jan 7;1(1):104-16. doi: 10.1039/b209637b. Org Biomol Chem. 2003. PMID: 12929396
As (+)-6 has been converted into the potent, naturally occurring salicylate anti-cancer agent, (-)-apicularen A in 8 steps, this study constitutes a formal total synthesis of (+)-apicularen A. ...
As (+)-6 has been converted into the potent, naturally occurring salicylate anti-cancer agent, (-)-apicularen A in 8 steps, th …
Inhibition of bone resorption in cultures of mouse calvariae by apicularen A.
Hong J, Sasaki H, Niikura K, Yanai M, Nakano Y, Yokomakura A, Ishihara K, Hirasawa N, Kang YS, Oh JS, Kwak JH, Zee O, Ohuchi K. Hong J, et al. Planta Med. 2007 Feb;73(2):173-5. doi: 10.1055/s-2006-957069. Planta Med. 2007. PMID: 17415879
Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1beta (IL-1beta) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 10 …
Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1beta (IL-1beta) was inhibited by …
33 results