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Symptomatic sassafras oil ingestion.
Grande GA, Dannewitz SR. Grande GA, et al. Vet Hum Toxicol. 1987 Dec;29(6):447. Vet Hum Toxicol. 1987. PMID: 3424652 No abstract available.
Biological reactive intermediates (BRIs) formed from botanical dietary supplements.
Dietz BM, Bolton JL. Dietz BM, et al. Chem Biol Interact. 2011 Jun 30;192(1-2):72-80. doi: 10.1016/j.cbi.2010.10.007. Epub 2010 Oct 21. Chem Biol Interact. 2011. PMID: 20970412 Free PMC article. Review.
While most botanical dietary supplements can be considered safe, a few contain compounds, which can be converted to biological reactive intermediates (BRIs) causing toxicity. For example, sassafras oil contains safrole, which can be converted to a reactive carbocati …
While most botanical dietary supplements can be considered safe, a few contain compounds, which can be converted to biological reactive inte …
Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography.
Schäffer M, Gröger T, Pütz M, Zimmermann R. Schäffer M, et al. Forensic Sci Int. 2013 Jun 10;229(1-3):108-15. doi: 10.1016/j.forsciint.2013.03.046. Epub 2013 Apr 24. Forensic Sci Int. 2013. PMID: 23683915
Analytical methods with adequate capacity to identify links and origin of precursors, such as safrole, provide valuable information for drug-related police intelligence. Authentic sassafras oil samples from police seizures were subjected to comparative analysis base …
Analytical methods with adequate capacity to identify links and origin of precursors, such as safrole, provide valuable information for drug …
Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation.
Hu L, Wu F, He J, Zhong L, Song Y, Shao H. Hu L, et al. Xenobiotica. 2019 Dec;49(12):1504-1515. doi: 10.1080/00498254.2019.1590882. Epub 2019 Jun 19. Xenobiotica. 2019. PMID: 30865484
Safrole is a natural compound categorized as a group 2B carcinogen extracted from sassafras oil or certain other essential oils. The hepatotoxicity of safrole has always been highly concerned. ...
Safrole is a natural compound categorized as a group 2B carcinogen extracted from sassafras oil or certain other essential oil …
Safrole-2',3'-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice.
Chiang SY, Lee PY, Lai MT, Shen LC, Chung WS, Huang HF, Wu KY, Wu HC. Chiang SY, et al. Mutat Res. 2011 Dec 24;726(2):234-41. doi: 10.1016/j.mrgentox.2011.09.014. Epub 2011 Oct 1. Mutat Res. 2011. PMID: 21986196
Safrole-2',3'-oxide (SAFO) is a reactive electrophilic metabolite of the hepatocarcinogen safrole, the main component of sassafras oil. Safrole occurs naturally in a variety of spices and herbs, including the commonly used Chinese medicine Xi xin (Asari Radix et Rhi …
Safrole-2',3'-oxide (SAFO) is a reactive electrophilic metabolite of the hepatocarcinogen safrole, the main component of sassafras …
Synthesis and cytotoxic activity of N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal.
Joselice e Silva M, Alves AJ, Do Nascimento SC. Joselice e Silva M, et al. Farmaco. 1998 Mar;53(3):241-3. doi: 10.1016/s0014-827x(97)00022-0. Farmaco. 1998. PMID: 9639871
Five new N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal were synthesized. Safrole, a natural product obtained from sassafras oil (Ocotea pretiosa), was oxidized to alcohol using BH3-THF and H2O2, followed by oxidation to aldehyde using pyri …
Five new N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal were synthesized. Safrole, a natural product obtained from …
A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes.
Gimeno P, Besacier F, Bottex M, Dujourdy L, Chaudron-Thozet H. Gimeno P, et al. Forensic Sci Int. 2005 Dec 20;155(2-3):141-57. doi: 10.1016/j.forsciint.2004.11.013. Forensic Sci Int. 2005. PMID: 16226151
Impurities found in various sources of precursors (sassafras oil, safrol, isosafrol, piperonal), intermediates (beta-nitroisosafrol, piperonylmethylketone (PMK)) and final product (3,4-methylenedioxymethamphetamine (MDMA)) are presented and discussed. ...Impurity pr …
Impurities found in various sources of precursors (sassafras oil, safrol, isosafrol, piperonal), intermediates (beta-nitroisos …
Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation.
Ueng YF, Hsieh CH, Don MJ, Chi CW, Ho LK. Ueng YF, et al. Chem Res Toxicol. 2004 Aug;17(8):1151-6. doi: 10.1021/tx030055p. Chem Res Toxicol. 2004. PMID: 15310247
Safrole is a natural plant constituent, found in sassafras oil and certain other essential oils. The carcinogenicity of safrole is mediated through 1'-hydroxysafrole formation, followed by sulfonation to an unstable sulfate that reacts to form DNA adducts. ...
Safrole is a natural plant constituent, found in sassafras oil and certain other essential oils. The carcinogenicity of safrol …
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