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KR-30450, a newly synthesized benzopyran derivative, activates the cardiac ATP-sensitive K+ channel.
Kwak YG, Park SK, Kang HS, Kim JS, Chae SW, Cho KP, Yoo SE, Kim D. Kwak YG, et al. J Pharmacol Exp Ther. 1995 Nov;275(2):807-12. J Pharmacol Exp Ther. 1995. PMID: 7473170
In cell-attached patches, KR-30450 (10(-5) M) in the pipette activated the KATP which was closed by 3 microM glibenclamide. In inside-out patches, the effects of KR-30450 on KATP activity were examined before and after run-down of the channel. ...
In cell-attached patches, KR-30450 (10(-5) M) in the pipette activated the KATP which was closed by 3 microM glibenclamide. In …
Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts.
Jung YS, Moon CH, Cho TS, Yoo SE, Shin HS. Jung YS, et al. Jpn J Pharmacol. 1998 Jan;76(1):65-73. doi: 10.1254/jjp.76.65. Jpn J Pharmacol. 1998. PMID: 9517406 Free article.
KR-30450 and KR-30818 significantly improved reperfusion cardiac function (LVDP, left ventricular developed pressure; double product, LVDP x heart rate/1000), their potency being 5.2-fold and 0.7-fold greater than lemakalim (ED50 for recovering predrug double produc …
KR-30450 and KR-30818 significantly improved reperfusion cardiac function (LVDP, left ventricular developed pressure; double p …
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Kwan YW, To KW, Lau WM, Tsang SH. Kwan YW, et al. Eur J Pharmacol. 1999 Jan 22;365(2-3):241-51. doi: 10.1016/s0014-2999(98)00768-7. Eur J Pharmacol. 1999. PMID: 9988108
The relative order of relaxation potency, estimated by comparing the IC50, was sodium nitroprusside > KR-30450 > aprikalim > or = cromakalim > pinacidil > nicorandil in pulmonary artery and aorta from both strains. At high concentrations (> or =1 m …
The relative order of relaxation potency, estimated by comparing the IC50, was sodium nitroprusside > KR-30450 > aprikal …
Antihypertensive effects of the novel potassium channel activator SKP-450 and its major metabolites in rats.
Shin HS, Seo HW, Oh JH, Lee BH. Shin HS, et al. Arzneimittelforschung. 1998 Oct;48(10):969-78. Arzneimittelforschung. 1998. PMID: 9825113
Antihypertensive effects of SKP-450 (KR-30450, CAS 172489-10-0, (-)-(2R)-2"-(1",3"-dioxolan-2-yl)-2-2methyl-4-(2'-oxopyrr olidin-1-yl)-6- nitro-2H-1-benzopyran), a newly synthesized potassium channel activator, and its major metabolites SKP-818 ((-)-(2R)-2"-hydroxym …
Antihypertensive effects of SKP-450 (KR-30450, CAS 172489-10-0, (-)-(2R)-2"-(1",3"-dioxolan-2-yl)-2-2methyl-4-(2'-oxopyrr olid …
12 results