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Page 1
ROP-ESAT6-CFP10 as Tuberculosis-Specific Antigen in Interferon Gamma Release Assay.
Kim MJ, Ha EH, Lee YK, Park SJ, An CH, Park SY, Kim SK. Kim MJ, et al. Ann Clin Lab Sci. 2022 Jan;52(1):126-132. Ann Clin Lab Sci. 2022. PMID: 35181626
We used ROP-ESAT6-CFP10 as a tuberculosis (TB)-specific antigen and compared it with existing interferon-gamma release assays (IGRAs). ...Samples were tested with QuantiFERON-TB Gold (QFT; QIAGEN Sciences Inc., USA), T-SPOT.TB (Oxford Immunotec, UK), and ELISpot usi …
We used ROP-ESAT6-CFP10 as a tuberculosis (TB)-specific antigen and compared it with existing interferon-gamma release assays …
CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents.
Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL. Tang XL, et al. J Infect. 2014 Dec;69(6):569-80. doi: 10.1016/j.jinf.2014.05.015. Epub 2014 Jun 23. J Infect. 2014. PMID: 24968239
In this study, we used a Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technique to screen for a functional ssDNA aptamer "antibody" that specifically bound to ESAT6-CFP10 (CE) protein. The selected single ssDNA aptamers (CE24 and CE15) demonstra …
In this study, we used a Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technique to screen for a functional ssDNA aptame …
Ag85b/ESAT6-CFP10 adjuvanted with aluminum/poly-IC effectively protects guinea pigs from latent mycobacterium tuberculosis infection.
Wang C, Lu J, Du W, Wang G, Li X, Shen X, Su C, Yang L, Chen B, Wang J, Xu M. Wang C, et al. Vaccine. 2019 Jul 26;37(32):4477-4484. doi: 10.1016/j.vaccine.2019.06.078. Epub 2019 Jun 29. Vaccine. 2019. PMID: 31266673
Herein we investigated the potential of Mycobacterium tuberculosis (Mtb) antigen proteins AEC comprised of Ag85b and ESAT6-CFP10 proteins in conjunction with aluminum (Al) and polyriboinosinic-polyribocytidylic acid (poly-IC) as a novel subunit vaccine against TB. . …
Herein we investigated the potential of Mycobacterium tuberculosis (Mtb) antigen proteins AEC comprised of Ag85b and ESAT6-CFP10
Effects of Mycobacterium tuberculosis ESAT6-CFP10 Protein on Cell Viability and Production of Nitric Oxide in Alveolar Macrophages.
Xie X, Han M, Zhang L, Liu L, Gu Z, Yang M, Yang H. Xie X, et al. Jundishapur J Microbiol. 2016 May 30;9(6):e33264. doi: 10.5812/jjm.33264. eCollection 2016 Jun. Jundishapur J Microbiol. 2016. PMID: 27635210 Free PMC article.
The recombinant pEGFP-N1-ESAT6-CFP10 plasmid was transfected into rat alveolar macrophage cells (NR8383). The cell line expressing the ESAT6-CFP10 protein was selected with RT-PCR and designated as NR8383-EC. ...
The recombinant pEGFP-N1-ESAT6-CFP10 plasmid was transfected into rat alveolar macrophage cells (NR8383). The cell line expres …
Evaluation of ESAT6-CFP10 Skin Test for Mycobacterium tuberculosis Infection among Persons Living with HIV in China.
Lu P, Wu K, Zhou H, Yu H, Yuan J, Dong L, Liu Q, Ding X, Lu W, Yang H, Zhu L, Martinez L. Lu P, et al. J Clin Microbiol. 2023 Apr 20;61(4):e0181622. doi: 10.1128/jcm.01816-22. Epub 2023 Mar 22. J Clin Microbiol. 2023. PMID: 36946732 Free PMC article.
Recent global guidelines recommend Mycobacterium tuberculosis antigen-based skin tests, such as the ESAT6-CFP10 (EC) skin test, as acceptable alternatives to the tuberculin skin test (TST) and the QuantiFERON-TB Gold In-Tube test (QFT). ...To our knowledge, this is …
Recent global guidelines recommend Mycobacterium tuberculosis antigen-based skin tests, such as the ESAT6-CFP10 (EC) skin test …
Safety of a Novel ESAT6-CFP10 skin test compared with tuberculin skin test in a double-blind, randomized, controlled study.
Yang Y, Fang Z, Huang W, Zhang H, Luo S, Lin S, Li S, Lu S. Yang Y, et al. BMC Infect Dis. 2022 Oct 11;22(1):780. doi: 10.1186/s12879-022-07765-w. BMC Infect Dis. 2022. PMID: 36221062 Free PMC article. Clinical Trial.
BACKGROUND: ESAT6-CFP10 (EC) skin test has been reported accurate and safe in identifying tuberculosis infection. ...
BACKGROUND: ESAT6-CFP10 (EC) skin test has been reported accurate and safe in identifying tuberculosis infection. ...
Recombinant fusion ESAT6-CFP10 immunogen as a skin test reagent for tuberculosis diagnosis: an open-label, randomized, two-centre phase 2a clinical trial.
Li F, Xu M, Qin C, Xia L, Xiong Y, Xi X, Fan X, Gu J, Pu J, Wu Q, Lu S, Wang G. Li F, et al. Clin Microbiol Infect. 2016 Oct;22(10):889.e9-889.e16. doi: 10.1016/j.cmi.2016.07.015. Epub 2016 Jul 21. Clin Microbiol Infect. 2016. PMID: 27451942 Free article. Clinical Trial.
When analysed in all participants, ESAT6-CFP10 had comparable AUC values to the ELISPOT assay (0.849 (95% CI, 0.835-0.952) vs. 0.908 (95% CI, 0.852-0.965)). Local itching (12/144, 8.3%) and pain (26/144, 18.1%) were the main side effects of ESAT6-CFP10
When analysed in all participants, ESAT6-CFP10 had comparable AUC values to the ELISPOT assay (0.849 (95% CI, 0.835-0.952) vs. …
High-yield production of major T-cell ESAT6-CFP10 fusion antigen of M. tuberculosis complex employing codon-optimized synthetic gene.
Gutiérrez-Ortega A, Moreno DA, Ferrari SA, Espinosa-Andrews H, Ortíz EP, Milián-Suazo F, Alvarez AH. Gutiérrez-Ortega A, et al. Int J Biol Macromol. 2021 Feb 28;171:82-88. doi: 10.1016/j.ijbiomac.2020.12.179. Epub 2021 Jan 6. Int J Biol Macromol. 2021. PMID: 33418045 Free article.
Obtention of heterologous multi-component antigens in E. coli without forming inclusion bodies remain a biotechnological challenge. The gene sequence for ESAT6-CFP10 fusion antigen was optimized by codon bias adjust for high-level expression as a soluble protein. .. …
Obtention of heterologous multi-component antigens in E. coli without forming inclusion bodies remain a biotechnological challenge. The gene …
Utility of recombinant fusion protein ESAT6-CFP10 skin test for differential diagnosis of active tuberculosis: A prospective study.
Yuan Y, Xia L, Wu Q, Liu X, Lu S. Yuan Y, et al. Front Immunol. 2023 Apr 25;14:1162177. doi: 10.3389/fimmu.2023.1162177. eCollection 2023. Front Immunol. 2023. PMID: 37180124 Free PMC article.
BACKGROUND: The recombinant mycobacterium tuberculosis fusion protein ESAT6-CFP10 skin test (ECST) is a novel test for tuberculosis (TB) infection; however, its accuracy in active tuberculosis (ATB) remains uncertain. ...
BACKGROUND: The recombinant mycobacterium tuberculosis fusion protein ESAT6-CFP10 skin test (ECST) is a novel test for tubercu …
Sensitivity, Specificity, and Safety of a Novel ESAT6-CFP10 Skin Test for Tuberculosis Infection in China: 2 Randomized, Self-Controlled, Parallel-Group Phase 2b Trials.
Xu M, Lu W, Li T, Li J, Du W, Wu Q, Liu Q, Yuan B, Lu J, Ding X, Li F, Liu M, Chen B, Pu J, Zhang R, Xi X, Zhou R, Mei Z, Du R, Tao L, Martinez L, Lu S, Wang G, Zhu F. Xu M, et al. Clin Infect Dis. 2022 Mar 1;74(4):668-677. doi: 10.1093/cid/ciab472. Clin Infect Dis. 2022. PMID: 34021314 Free PMC article. Clinical Trial.
BACKGROUND: Diagnostics to identify tuberculosis infection are limited. We aimed to assess the diagnostic accuracy and safety of ESAT6-CFP10 (EC) skin test for tuberculosis infection in Chinese adults. ...
BACKGROUND: Diagnostics to identify tuberculosis infection are limited. We aimed to assess the diagnostic accuracy and safety of ESAT6
85 results