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An Herbal Extract Combination (Biochanin A, Acetyl tetrapeptide-3, and Ginseng Extracts) versus 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A 24-week, Prospective, Randomized, Triple-blind, Controlled Trial.
Lueangarun S, Panchaprateep R. Lueangarun S, et al. J Clin Aesthet Dermatol. 2020 Oct;13(10):32-37. Epub 2020 Oct 1. J Clin Aesthet Dermatol. 2020. PMID: 33584955 Free PMC article.
OBJECTIVE: We sought to evaluate the efficacy and safety profile of an herbal extract combination comprising biochanin A, acetyl tetrapeptide-3, and ginseng extracts, and compare this to 3% minoxidil solution for the treatment of andogenetic alopecia (AGA). ...
OBJECTIVE: We sought to evaluate the efficacy and safety profile of an herbal extract combination comprising biochanin A, acetyl tetrapep
Pharmacokinetic investigation of a 14C-labelled beta 3/alpha tetrapeptide in rats.
Wiegand H, Wirz B, Schweitzer A, Gross G, Perez MI, Andres H, Kimmerlin T, Rueping M, Seebach D. Wiegand H, et al. Chem Biodivers. 2004 Nov;1(11):1812-28. doi: 10.1002/cbdv.200490136. Chem Biodivers. 2004. PMID: 17191818
A comparison with a previous ADME investigation of a beta-nonapeptide show that--except for the lack of metabolism--all aspects of exposure, distribution, and elimination are different (structure-specific properties). The investigated tetrapeptide 3 is a potent and …
A comparison with a previous ADME investigation of a beta-nonapeptide show that--except for the lack of metabolism--all aspects of exposure, …
Enhanced delivery of hydrophilic peptides in vitro by transdermal microneedle pretreatment.
Zhang S, Qiu Y, Gao Y. Zhang S, et al. Acta Pharm Sin B. 2014 Feb;4(1):100-4. doi: 10.1016/j.apsb.2013.12.011. Epub 2014 Jan 24. Acta Pharm Sin B. 2014. PMID: 26579370 Free PMC article.
The aims of this study were to investigate the utility of solid microneedle arrays (150 m in length) in enhancing transdermal delivery of peptides and to examine the relationship between peptide permeation rates and D2O flux. Four model peptides were used (Gly-Gln-Pro-Arg [tet
The aims of this study were to investigate the utility of solid microneedle arrays (150 m in length) in enhancing transdermal delivery of pe …
Low-molecular-weight gelators consisting of hybrid cyclobutane-based peptides.
Celis S, Nolis P, Illa O, Branchadell V, Ortuño RM. Celis S, et al. Org Biomol Chem. 2013 May 7;11(17):2839-46. doi: 10.1039/c3ob27347d. Epub 2013 Mar 14. Org Biomol Chem. 2013. PMID: 23493972
Scanning electron microscopy (SEM) and circular dichroism (CD) pointed out that peptide 1, which contains the shortest C2 linear residue, presented the most defined fibril network and afforded nanoscale helical aggregates. Tetrapeptide 3, with C4 linear residues in …
Scanning electron microscopy (SEM) and circular dichroism (CD) pointed out that peptide 1, which contains the shortest C2 linear residue, pr …
One-armed artificial receptors for the binding of polar tetrapeptides in water: probing the substrate selectivity of a combinatorial receptor library.
Schmuck C, Heil M. Schmuck C, et al. Chemistry. 2006 Feb 1;12(5):1339-48. doi: 10.1002/chem.200501062. Chemistry. 2006. PMID: 16315202
This "inverse" substrate is also efficiently bound by our receptors, with K(ass) approximately 6000 M(-1) for the best receptors, as determined both by a quantitative on-bead binding assay and by UV and fluorescence titration studies in free solution. Hence, the inverse tetrap
This "inverse" substrate is also efficiently bound by our receptors, with K(ass) approximately 6000 M(-1) for the best receptors, as determi …
Solution structure of peptides containing two dehydro-phenylalanine residues: a CD investigation.
Pieroni O, Fissi A, Pratesi C, Temussi PA, Ciardelli F. Pieroni O, et al. Biopolymers. 1993 Jan;33(1):1-10. doi: 10.1002/bip.360330102. Biopolymers. 1993. PMID: 8427926
The tripeptides 1 and 2 exhibited an intense negative CD exciton couplet, which was assigned to the right-handed screw sense, while the tetrapeptide 3 displayed a CD couplet having opposite sign, which was assigned to the left-handed helical sense. ...
The tripeptides 1 and 2 exhibited an intense negative CD exciton couplet, which was assigned to the right-handed screw sense, while the t