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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 11
1946 17
1947 15
1948 17
1949 5
1950 5
1951 5
1952 5
1953 2
1954 1
1955 3
1958 1
1959 2
1962 1
1964 1
1969 1
1973 7
1983 1
1985 1
1987 1
1988 2
1989 2
1990 1
1991 1
1992 8
1993 6
1994 5
1995 5
1996 7
1997 3
1998 1
1999 3
2000 1
2001 2
2002 6
2003 6
2004 5
2005 3
2006 3
2007 4
2008 4
2009 4
2010 3
2011 5
2012 3
2013 6
2014 2
2015 7
2016 2
2017 5
2018 6
2019 6
2020 7
2021 6
2022 6
2023 2
2024 4

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237 results

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Page 1
Familial hypercholesterolemia--epidemiology, diagnosis, and screening.
Singh S, Bittner V. Singh S, et al. Curr Atheroscler Rep. 2015;17(2):482. doi: 10.1007/s11883-014-0482-5. Curr Atheroscler Rep. 2015. PMID: 25612857 Review.
Mutations in four genes have been noted in patients with familial hypercholesterolemia (FH): LDL receptor (most common), apolipoprotein B (Apo B), proprotein convertase subtilin/kexin 9 (PCSK9), and low-density lipoprotein receptor adaptor protein (LDLRAP). ...
Mutations in four genes have been noted in patients with familial hypercholesterolemia (FH): LDL receptor (most common), apolipoprotein B (A …
LanI-Mediated Lantibiotic Immunity in Bacillus subtilis: Functional Analysis.
Geiger C, Korn SM, Häsler M, Peetz O, Martin J, Kötter P, Morgner N, Entian KD. Geiger C, et al. Appl Environ Microbiol. 2019 May 16;85(11):e00534-19. doi: 10.1128/AEM.00534-19. Print 2019 Jun 1. Appl Environ Microbiol. 2019. PMID: 30952662 Free PMC article.
Using laser-induced liquid bead ion desorption (LILBID)-mass spectrometry, we show here that subtilin interacts with SpaI monomers. The expression of either SpaI or NisI in a subtilin-nonproducing B. subtilis strain resulted in the respective strain being more resis …
Using laser-induced liquid bead ion desorption (LILBID)-mass spectrometry, we show here that subtilin interacts with SpaI monomers. T …
Regulation of heterologous subtilin production in Bacillus subtilis W168.
Zhang Q, Kobras CM, Gebhard S, Mascher T, Wolf D. Zhang Q, et al. Microb Cell Fact. 2022 Apr 7;21(1):57. doi: 10.1186/s12934-022-01782-9. Microb Cell Fact. 2022. PMID: 35392905 Free PMC article.
Despite the pioneer understanding on subtilin biosynthesis, a robust platform to facilitate subtilin research and improve subtilin production is still a poorly explored spot. ...In addition, by incorporating the subtilin-producing system (spa-locus) an …
Despite the pioneer understanding on subtilin biosynthesis, a robust platform to facilitate subtilin research and improve s …
Specificity of Subtilin-Mediated Activation of Histidine Kinase SpaK.
Geiger C, Spieß T, Korn SM, Kötter P, Entian KD. Geiger C, et al. Appl Environ Microbiol. 2017 Aug 31;83(18):e00781-17. doi: 10.1128/AEM.00781-17. Print 2017 Sep 15. Appl Environ Microbiol. 2017. PMID: 28710266 Free PMC article.
Furthermore, the overall structure of subtilin is also important for its association with the histidine kinase. The destruction of the second lanthionine ring (subtilin C11A, ring B), as well as mutations that interfere with the flexibility of the hinge region locat …
Furthermore, the overall structure of subtilin is also important for its association with the histidine kinase. The destruction of th …
Immunity to lantibiotics.
Saris PE, Immonen T, Reis M, Sahl HG. Saris PE, et al. Antonie Van Leeuwenhoek. 1996 Feb;69(2):151-9. doi: 10.1007/BF00399420. Antonie Van Leeuwenhoek. 1996. PMID: 8775975 Review.
In Lactococcus lactis and Bacillus subtilis the putative immunity lipoproteins NisI and SpaI, respectively, are also located at the outer surface of the cytoplasmic membrane, suggesting that a similar mechanism might be utilized by the producers of nisin and subtilin. In a …
In Lactococcus lactis and Bacillus subtilis the putative immunity lipoproteins NisI and SpaI, respectively, are also located at the outer su …
Autoinduction Specificities of the Lantibiotics Subtilin and Nisin.
Spieß T, Korn SM, Kötter P, Entian KD. Spieß T, et al. Appl Environ Microbiol. 2015 Nov;81(22):7914-23. doi: 10.1128/AEM.02392-15. Epub 2015 Sep 4. Appl Environ Microbiol. 2015. PMID: 26341212 Free PMC article.
The biosynthesis of the lantibiotics subtilin and nisin is regulated by autoinduction via two-component systems. ...Autoinduction is highly specific for the respective lantibiotic and therefore of major importance for the functional expression of genetically engineered …
The biosynthesis of the lantibiotics subtilin and nisin is regulated by autoinduction via two-component systems. ...Autoinduction is …
Autoregulation of subtilin biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin-responsive promoters.
Kleerebezem M, Bongers R, Rutten G, de Vos WM, Kuipers OP. Kleerebezem M, et al. Peptides. 2004 Sep;25(9):1415-24. doi: 10.1016/j.peptides.2003.11.025. Peptides. 2004. PMID: 15374645
The lantibiotics nisin and subtilin act as extracellular regulators of their own biosynthesis. ...Three subtilin-responsive promoter elements within the spaBTCSIFEGRK are controlled by the specific cis-acting sequence element called the spa-box, which represents the …
The lantibiotics nisin and subtilin act as extracellular regulators of their own biosynthesis. ...Three subtilin-responsive pr …
Enhancement of the chemical and antimicrobial properties of subtilin by site-directed mutagenesis.
Liu W, Hansen JN. Liu W, et al. J Biol Chem. 1992 Dec 15;267(35):25078-85. J Biol Chem. 1992. PMID: 1460009 Free article.
The DHA5 of this mutant subtilin (E4I-subtilin) underwent modification with a t1/2 of 48 days, which is 57-fold slower than natural subtilin, and the rate of loss of biological activity dropped by a like amount. These results suggest that an intact DHA5 is cr …
The DHA5 of this mutant subtilin (E4I-subtilin) underwent modification with a t1/2 of 48 days, which is 57-fold slower than na …
Antibiotics synthesized by posttranslational modification.
Hansen JN. Hansen JN. Annu Rev Microbiol. 1993;47:535-64. doi: 10.1146/annurev.mi.47.100193.002535. Annu Rev Microbiol. 1993. PMID: 8257108 Review.
A particularly interesting class of these antimicrobial peptides is the lantibiotics, of which nisin and subtilin are the longest-known examples, although nearly a dozen new lantibiotics have been discovered in recent years. ...
A particularly interesting class of these antimicrobial peptides is the lantibiotics, of which nisin and subtilin are the longest-kno …
Activation of subtilin precursors by Bacillus subtilis extracellular serine proteases subtilisin (AprE), WprA, and Vpr.
Corvey C, Stein T, Düsterhus S, Karas M, Entian KD. Corvey C, et al. Biochem Biophys Res Commun. 2003 Apr 25;304(1):48-54. doi: 10.1016/s0006-291x(03)00529-1. Biochem Biophys Res Commun. 2003. PMID: 12705882
To identify subtilin processing activities, we used antimicrobial inactive subtilin precursors consisting of the leader peptide which was still attached to the fully matured propeptide. ...Vpr was identified as the third protease capable to process subtilin.. …
To identify subtilin processing activities, we used antimicrobial inactive subtilin precursors consisting of the leader peptid …
237 results