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Health promoting benefits of pongamol: An overview.
Jahan S, Mahmud MH, Khan Z, Alam A, Khalil AA, Rauf A, Tareq AM, Nainu F, Tareq SM, Emran TB, Khan M, Khan IN, Wilairatana P, Mubarak MS. Jahan S, et al. Biomed Pharmacother. 2021 Oct;142:112109. doi: 10.1016/j.biopha.2021.112109. Epub 2021 Aug 27. Biomed Pharmacother. 2021. PMID: 34470730 Free article. Review.
Various in vivo and in vitro studies revealed that pongamol is a potentially active agent, as it exerts anticancer, anti-inflammatory, antioxidant, antimicrobial, and anti-diabetic activities. Accordingly, the aim of the present review was to give an up-to-date overview on …
Various in vivo and in vitro studies revealed that pongamol is a potentially active agent, as it exerts anticancer, anti-inflammatory …
A chalcone (Pongamol) and phytoconstituents of Tephrosia purpurea.
Sahayaraj K, Kombiah P, Rathi JAM. Sahayaraj K, et al. Nat Prod Res. 2022 Apr;36(7):1870-1873. doi: 10.1080/14786419.2020.1808640. Epub 2020 Aug 25. Nat Prod Res. 2022. PMID: 32840388
Secondary metabolites contents were higher in stem than root of T. purpurea. It is the first time a chalcone (Pongamol) was crystallised from the column chromatography fraction of T. purpurea stem extract identified by using FT-IR and XRD. ...
Secondary metabolites contents were higher in stem than root of T. purpurea. It is the first time a chalcone (Pongamol) was crystalli …
Pongamol Inhibits Epithelial to Mesenchymal Transition Through Suppression of FAK/Akt-mTOR Signaling.
Putri HE, Sritularak B, Chanvorachote P. Putri HE, et al. Anticancer Res. 2021 Dec;41(12):6147-6154. doi: 10.21873/anticanres.15434. Anticancer Res. 2021. PMID: 34848469
Apoptosis and necrosis induction in response to pongamol treatment was observed and visualized by nuclei staining assay. ...Regarding the up-stream mechanisms, we found that pongamol inhibited activation of FAK and Akt/mTOR signaling pathways. ...
Apoptosis and necrosis induction in response to pongamol treatment was observed and visualized by nuclei staining assay. ...Regarding …
Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H(2)O(2)-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans.
Wu S, Miao J, Zhu S, Wu X, Shi J, Zhou J, Xing Y, Hu K, Ren J, Yang H. Wu S, et al. Mol Neurobiol. 2024 Mar 14. doi: 10.1007/s12035-024-04110-x. Online ahead of print. Mol Neurobiol. 2024. PMID: 38483657
Our findings revealed that pongamol reduced cellular damage and apoptosis in H(2)O(2)-induced PC12 cells. ...Furthermore, pongamol exerted neuroprotective and anti-aging effects in C. elegans. ...
Our findings revealed that pongamol reduced cellular damage and apoptosis in H(2)O(2)-induced PC12 cells. ...Furthermore, pongamol …
Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells.
Tamrakar AK, Jaiswal N, Yadav PP, Maurya R, Srivastava AK. Tamrakar AK, et al. Mol Cell Endocrinol. 2011 Jun 6;339(1-2):98-104. doi: 10.1016/j.mce.2011.03.023. Epub 2011 Apr 8. Mol Cell Endocrinol. 2011. PMID: 21497640
Cycloheximide treatment inhibited the effect of pongamol on GLUT4 translocation suggesting the requirement of new protein synthesis. The pongamol-induced increase in GLUT4 translocation was completely abolished by wortmannin, and pongamol significantly potent …
Cycloheximide treatment inhibited the effect of pongamol on GLUT4 translocation suggesting the requirement of new protein synthesis. …
Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.
Tamrakar AK, Yadav PP, Tiwari P, Maurya R, Srivastava AK. Tamrakar AK, et al. J Ethnopharmacol. 2008 Aug 13;118(3):435-9. doi: 10.1016/j.jep.2008.05.008. Epub 2008 May 15. J Ethnopharmacol. 2008. PMID: 18572336
AIM OF THE STUDY: To identify pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. MATERIAL AND METHODS: Streptozotocin-induced diabetic rats and hyperglycemic, hyperlipidemic and hyperinsulinemic db/db mice were used to inv …
AIM OF THE STUDY: To identify pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. M …
A comprehensive review on ethnomedicine, phytochemistry, pharmacology, and toxicity of Tephrosia purpurea (L.) Pers.
Rao AS, Yadav SS, Singh P, Nandal A, Singh N, Ganaie SA, Yadav N, Kumar R, Bhandoria MS, Bansal P. Rao AS, et al. Phytother Res. 2020 Aug;34(8):1902-1925. doi: 10.1002/ptr.6657. Epub 2020 Mar 8. Phytother Res. 2020. PMID: 32147928 Review.
It is an important component of herbal preparations like Tephroli and Yakrifti used to cure liver disorders. Various phytocompounds including pongamol, purpurin, purpurenone, tephrosin, bulnesol, tephrostachin, beta-sitosterol, and so on have been reported. ...
It is an important component of herbal preparations like Tephroli and Yakrifti used to cure liver disorders. Various phytocompounds includin …
Quantification and Optimization of Ethanolic Extract Containing the Bioactive Flavonoids from Millettia pulchra Radix.
Vo TH, Liaw CC, Lin YC, Nguyen DH, Nguyen TTN, Lee CK, Kuo YH. Vo TH, et al. Molecules. 2021 Jun 15;26(12):3641. doi: 10.3390/molecules26123641. Molecules. 2021. PMID: 34203624 Free PMC article.
Four major flavonoid derivatives (karanjin, lanceolatin B, 2",2"-dimethylpyrano-[5",6":7,8]-flavone, and pongamol) were isolated using silica gel column chromatography, crystallization techniques in large amounts with high purities (>95%). ...
Four major flavonoid derivatives (karanjin, lanceolatin B, 2",2"-dimethylpyrano-[5",6":7,8]-flavone, and pongamol) were isolated usin …
Revisiting curcumin chemistry part I: a new strategy for the synthesis of curcuminoids.
Rao EV, Sudheer P. Rao EV, et al. Indian J Pharm Sci. 2011 May;73(3):262-70. doi: 10.4103/0250-474X.93508. Indian J Pharm Sci. 2011. PMID: 22457548 Free PMC article.
The intermediate curcuminoid difluroboronites, as also the natural beta-diketone pongamol difluroboronite, prepared for the first time were characterized on the basis of physical and chemical properties and spectroscopic data. ...
The intermediate curcuminoid difluroboronites, as also the natural beta-diketone pongamol difluroboronite, prepared for the first tim …
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Sharma R, Williams IS, Gatchie L, Sonawane VR, Chaudhuri B, Bharate SB. Sharma R, et al. Bioorg Med Chem. 2018 Dec 15;26(23-24):6076-6086. doi: 10.1016/j.bmc.2018.11.013. Epub 2018 Nov 10. Bioorg Med Chem. 2018. PMID: 30448188
Its secondary metabolites, the furanoflavonoids pongapin/lanceolatin B, inhibit CYP1A1 with IC(50) of 20 nM. Although the furanochalcone pongamol inhibits CYP1A1 with IC(50) of only 4.4 M, a semisynthetic pyrazole-derivative P5b, has 10-fold improved potency (IC(50), 0.49 …
Its secondary metabolites, the furanoflavonoids pongapin/lanceolatin B, inhibit CYP1A1 with IC(50) of 20 nM. Although the furanochalcone …
19 results