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Analogues of 8-azaguanosine.
Elliot RD, Montgomery JA. Elliot RD, et al. J Med Chem. 1976 Oct;19(10):1186-91. doi: 10.1021/jm00232a004. J Med Chem. 1976. PMID: 1033290
The reaction of 5 with 2,3,5-tri-O-acetyl-D-ribofuranosyl chloride gave a mixture of the 7-, 8-, and 9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-8-azapurines 4a-c which was converted to 8-azaguanosine (7c) and the corresponding 7- and 8-substituted isomers 7a and 7b. 4a-c …
The reaction of 5 with 2,3,5-tri-O-acetyl-D-ribofuranosyl chloride gave a mixture of the 7-, 8-, and 9-(2,3,5-tri-O-acetyl-beta-D-ribofurano …
Bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(pom) phosphotriester prodrugs of 2'-deoxy-4'-thioadenosine and its corresponding 9alpha anomer.
Rose JD, Parker WB, Secrist JA 3rd. Rose JD, et al. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):809-13. doi: 10.1081/ncn-200061889. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16248041
Accordingly, we report synthesis and biological evaluation of the bis(tBuSA TE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside, nucleoside analogs with moderate to significant cytotoxicity. ...
Accordingly, we report synthesis and biological evaluation of the bis(tBuSA TE) phosphotriester prodrugs of 8-azaguanosine and 6-meth …
8-azaguanosine-5'-monophosphate synthesis via nucleoside kinase in cultured Chinese hamster lung fibroblasts.
Tozzi MG, Camici M, Falcone V, Turriani M, Turchi G, Ipata PL. Tozzi MG, et al. Biochem Biophys Res Commun. 1989 Mar 15;159(2):854-61. doi: 10.1016/0006-291x(89)90073-9. Biochem Biophys Res Commun. 1989. PMID: 2539130
Cultured chinese hamster lung fibroblasts, and a variant clone selected for resistance to 8-azaguanine, that lacks hypoxanthine-guanine phosphoribosyl transferase (EC 2.4.2.8), have been tested for the ability to convert 8-azaguanine into 8-azaguanosine-5'-monophosphate vi …
Cultured chinese hamster lung fibroblasts, and a variant clone selected for resistance to 8-azaguanine, that lacks hypoxanthine-guanine phos …
Cytosolic 5'-nucleotidase/nucleoside phosphotransferase: a nucleoside analog activating enzyme?
Turriani M, Pesi R, Nardone A, Turchi G, Sgarrella F, Ipata PL, Tozzi MG. Turriani M, et al. J Biochem Toxicol. 1994 Feb;9(1):51-7. doi: 10.1002/jbt.2570090108. J Biochem Toxicol. 1994. PMID: 8151632
The cytosolic 5'-nucleotidase/phosphotransferase substrate, 8-azaguanosine, was found to be very toxic for cultured fibroblasts (LD50 = 0.32 microM). Mutants resistant to either 8-azaguanosine and the correspondent base 8-azaguanine were isolated and characterized. …
The cytosolic 5'-nucleotidase/phosphotransferase substrate, 8-azaguanosine, was found to be very toxic for cultured fibroblasts (LD50 …
8-Azaguanine reporter of purine ionization states in structured RNAs.
Da Costa CP, Fedor MJ, Scott LG. Da Costa CP, et al. J Am Chem Soc. 2007 Mar 21;129(11):3426-32. doi: 10.1021/ja067699e. Epub 2007 Feb 28. J Am Chem Soc. 2007. PMID: 17326637
The fluorescent nucleotide analogue 8-azaguanosine-5'-triphosphate (8azaGTP) is prepared easily by in vitro enzymatic synthesis methods. 8azaGTP is an efficient substrate for T7 RNA polymerase and is incorporated specifically opposite cytosine in the transcription template …
The fluorescent nucleotide analogue 8-azaguanosine-5'-triphosphate (8azaGTP) is prepared easily by in vitro enzymatic synthesis metho …
24 results