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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 3
1997 3
1998 3
1999 2
2000 2
2001 2
2002 2
2004 2
2005 1
2006 1
2007 1
2010 1
2011 1
2015 1
2024 0

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26 results

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Page 1
Anti-HIV-1 activity and mode of action of mirror image oligodeoxynucleotide analogue of Zintevir.
Urata H, Kumashiro T, Kawahata T, Otake T, Akagi M. Urata H, et al. Biochem Biophys Res Commun. 2004 Jan 2;313(1):55-61. doi: 10.1016/j.bbrc.2003.11.094. Biochem Biophys Res Commun. 2004. PMID: 14672697
We synthesized the non-modified analogue (D-17mer) of Zintevir and its enantiomer (L-17mer), and compared their anti-HIV-1 activity and molecular mechanism of action. Although L-17mer forms the exact mirror image quadruplex structure of D-17mer, which has a very similar st …
We synthesized the non-modified analogue (D-17mer) of Zintevir and its enantiomer (L-17mer), and compared their anti-HIV-1 activity a …
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
Esté JA, Cabrera C, Schols D, Cherepanov P, Gutierrez A, Witvrouw M, Pannecouque C, Debyser Z, Rando RF, Clotet B, Desmyter J, De Clercq E. Esté JA, et al. Mol Pharmacol. 1998 Feb;53(2):340-5. doi: 10.1124/mol.53.2.340. Mol Pharmacol. 1998. PMID: 9463493
The human immunodeficiency virus (HIV) inhibitor AR177 (T30177, Zintevir) has been identified as a potent inhibitor of HIV integrase in vitro. ...
The human immunodeficiency virus (HIV) inhibitor AR177 (T30177, Zintevir) has been identified as a potent inhibitor of HIV integrase …
New developments in anti-HIV chemotherapy.
De Clercq E. De Clercq E. Curr Med Chem. 2001 Nov;8(13):1543-72. doi: 10.2174/0929867013371842. Curr Med Chem. 2001. PMID: 11562282 Free article. Review.
In addition to the reverse transcriptase and protease step, various other events in the HIV replicative cycle are potential targets for chemotherapeutic intervention: (i) viral adsorption, through binding to the viral envelope glycoprotein gp120 (polysulfates, polysulfonates, pol …
In addition to the reverse transcriptase and protease step, various other events in the HIV replicative cycle are potential targets for chem …
Novel compounds in preclinical/early clinical development for the treatment of HIV infections.
De Clercq E. De Clercq E. Rev Med Virol. 2000 Jul-Aug;10(4):255-77. doi: 10.1002/1099-1654(200007/08)10:4<255::aid-rmv282>3.0.co;2-6. Rev Med Virol. 2000. PMID: 10891872 Review.
In addition to the reverse transcriptase and protease step, various other events in the HIV replicative cycle are potential targets for chemotherapeutic intervention: (i) viral adsorption, through binding to the viral envelope glycoprotein gp120 (polysulphates, polysulphonates, p …
In addition to the reverse transcriptase and protease step, various other events in the HIV replicative cycle are potential targets for chem …
New advances in HIV entry inhibitors development.
Rusconi S, Scozzafava A, Mastrolorenzo A, Supuran CT. Rusconi S, et al. Curr Drug Targets Infect Disord. 2004 Dec;4(4):339-55. doi: 10.2174/1568005043340498. Curr Drug Targets Infect Disord. 2004. PMID: 15578975 Review.
Thus, several inhibitors of the gp120-CD4 interaction have been detected so far (zintevir, FP-21399 and BMS-378806 in clinical trials). Small molecule chemokine receptor antagonists acting as HIV entry inhibitors also were described in the last period, which interact both …
Thus, several inhibitors of the gp120-CD4 interaction have been detected so far (zintevir, FP-21399 and BMS-378806 in clinical trials …
Anti-HIV-1 activity of L-DNA quadruplex.
Urata H, Kumashiro T, Otake T, Kawahata T, Akagi M. Urata H, et al. Nucleic Acids Res Suppl. 2002;(2):163-4. doi: 10.1093/nass/2.1.163. Nucleic Acids Res Suppl. 2002. PMID: 12903156
The quadruplex formation is thought to be essential for the anti-HIV-1 activity of Zintevir. We synthesized the enantiomer of Zintevir and evaluated its structure and anti-HIV-1 activity. The results showed that the enantiomer has anti-HIV-1 activity comparable to t …
The quadruplex formation is thought to be essential for the anti-HIV-1 activity of Zintevir. We synthesized the enantiomer of Zint …
In search of authentic inhibitors of HIV-1 integration.
Debyser Z, Cherepanov P, Van Maele B, De Clercq E, Witvrouw M. Debyser Z, et al. Antivir Chem Chemother. 2002 Jan;13(1):1-15. doi: 10.1177/095632020201300101. Antivir Chem Chemother. 2002. PMID: 12180645 Free article. Review.
Synthesis and properties of G-quartet oligonucleotide-HIV-1 tat peptide conjugate.
Kumashiro T, Otake T, Kawahata T, Akagi M, Urata H. Kumashiro T, et al. Nucleic Acids Symp Ser (Oxf). 2006;(50):177-8. doi: 10.1093/nass/nrl088. Nucleic Acids Symp Ser (Oxf). 2006. PMID: 17150875
Zintevir was discovered as a potent inhibitor for HIV-1 integrase. Recently, the primary molecular target of Zintevir, however, was shown to be the HIV-1 gp120. In fact, in our previous study, Zintevir was shown to inhibit the only processes of the viral adso …
Zintevir was discovered as a potent inhibitor for HIV-1 integrase. Recently, the primary molecular target of Zintevir, however …
An update in the development of HIV entry inhibitors.
Rusconi S, Scozzafava A, Mastrolorenzo A, Supuran CT. Rusconi S, et al. Curr Top Med Chem. 2007;7(13):1273-89. doi: 10.2174/156802607781212239. Curr Top Med Chem. 2007. PMID: 17627557 Review.
Thus, several inhibitors of the gp120-CD4 interaction have been detected so far (zintevir, FP-21399 and BMS-378806 in clinical trials). Small molecule chemokine receptor antagonists acting as HIV entry inhibitors also were described in the last period, which interact both …
Thus, several inhibitors of the gp120-CD4 interaction have been detected so far (zintevir, FP-21399 and BMS-378806 in clinical trials …
Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome.
Barbaro G, Scozzafava A, Mastrolorenzo A, Supuran CT. Barbaro G, et al. Curr Pharm Des. 2005;11(14):1805-43. doi: 10.2174/1381612053764869. Curr Pharm Des. 2005. PMID: 15892677 Review.
Thus, inhibitors of the gp120-CD4 interaction have been detected (zintevir, FP-21399 and BMS-378806 in clinical trials). Small molecule chemokine antagonists acting as HIV entry inhibitors also were described in the last period, which interact both with the CXCR4 corecepto …
Thus, inhibitors of the gp120-CD4 interaction have been detected (zintevir, FP-21399 and BMS-378806 in clinical trials). Small molecu …
26 results