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Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival.
Jiang T, Zhang J, Ruan B, Xi X, Yang Z, Liu J, Zhao H, Xu X, Jiang M. Jiang T, et al. Chin Med. 2024 Mar 1;19(1):37. doi: 10.1186/s13020-024-00909-x. Chin Med. 2024. PMID: 38429848 Free PMC article.
Lem. extract suppressed osteoclastogenesis and identified trachelogenin (TCG) as a representative compound. Here, we delved into TCG's potential to alleviate OA. ...
Lem. extract suppressed osteoclastogenesis and identified trachelogenin (TCG) as a representative compound. Here, we delved into TCG' …
Trachelogenin, a novel inhibitor of hepatitis C virus entry through CD81.
Qian XJ, Jin YS, Chen HS, Xu QQ, Ren H, Zhu SY, Tang HL, Wang Y, Zhao P, Qi ZT, Zhu YZ. Qian XJ, et al. J Gen Virol. 2016 May;97(5):1134-1144. doi: 10.1099/jgv.0.000432. Epub 2016 Feb 15. J Gen Virol. 2016. PMID: 26879209
Here, we report the identification of a natural plant-derived lignan, trachelogenin (TGN), as a potent entry inhibitor of HCV without genotype specificity, and with low cytotoxicity. ...
Here, we report the identification of a natural plant-derived lignan, trachelogenin (TGN), as a potent entry inhibitor of HCV without …
Effects of dibenzylbutyrolactone lignans arctigenin and trachelogenin on the motility of isolated rat ileum.
Koech PK, Boldizsár I, Dobolyi A, Varró P. Koech PK, et al. Toxicol Rep. 2022 May 27;9:1222-1232. doi: 10.1016/j.toxrep.2022.05.019. eCollection 2022. Toxicol Rep. 2022. PMID: 36518476 Free PMC article.
The purpose of the study was to determine the effects of two such lignans, arctigenin and trachelogenin on the motility of isolated rat ileum and obtain indications on their mechanism of action. ...Our results demonstrate relaxant effect of arctigenin and trachelogenin …
The purpose of the study was to determine the effects of two such lignans, arctigenin and trachelogenin on the motility of isolated r …
Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin - An ex vivo Study on Rat Brain Slices.
Koech PK, Jócsák G, Boldizsár I, Moldován K, Borbély S, Világi I, Dobolyi A, Varró P. Koech PK, et al. Planta Med. 2023 Aug;89(9):879-889. doi: 10.1055/a-2005-5497. Epub 2023 Jan 2. Planta Med. 2023. PMID: 36592636
Trachelogenin effect (0.5 M, 10 M, 20 M) was comparable to arctigenin (1 M, 20 M, 40 M) (p > 0.05). ...The results suggest that trachelogenin and arctigenin act via inhibition of AMPA and KA receptors in the brain and trachelogenin has a higher potency tha …
Trachelogenin effect (0.5 M, 10 M, 20 M) was comparable to arctigenin (1 M, 20 M, 40 M) (p > 0.05). ...The results suggest that …
Enhancing Effect of Trachelogenin from Trachelospermi caulis Extract on Intestinal Barrier Function.
Shin HS, Bae MJ, Jung SY, See HJ, Kim YT, Do JR, Back SY, Choi SW, Shon DH. Shin HS, et al. Biol Pharm Bull. 2015;38(11):1707-13. doi: 10.1248/bpb.b15-00332. Epub 2015 Aug 11. Biol Pharm Bull. 2015. PMID: 26268064 Free article.
Chloroform and ethyl acetate fractions showed increased TEER values and decreased OVA flux. Chloroform and ethyl acetate fractions contained mainly trachelogenin and its glycoside, tracheloside. Trachelogenin increased TEER values and decreased OVA flux by enhancing …
Chloroform and ethyl acetate fractions showed increased TEER values and decreased OVA flux. Chloroform and ethyl acetate fractions contained …
Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases.
Bailly C, Thuru X. Bailly C, et al. Cancers (Basel). 2023 Apr 6;15(7):2186. doi: 10.3390/cancers15072186. Cancers (Basel). 2023. PMID: 37046846 Free PMC article. Review.
Several monoclonal antibodies anti-CD81 have been developed, notably mAb 5A6 active against invasion and metastasis of triple-negative breast cancer cells. CD81-EC2 can also be targeted with natural products (trachelogenin and harzianoic acids A-B) and synthetic compounds …
Several monoclonal antibodies anti-CD81 have been developed, notably mAb 5A6 active against invasion and metastasis of triple-negative breas …
In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells.
Moura AF, Lima KSB, Sousa TS, Marinho-Filho JDB, Pessoa C, Silveira ER, Pessoa ODL, Costa-Lotufo LV, Moraes MO, Araújo AJ. Moura AF, et al. Toxicol In Vitro. 2018 Mar;47:129-136. doi: 10.1016/j.tiv.2017.11.014. Epub 2017 Nov 22. Toxicol In Vitro. 2018. PMID: 29174024
Lignans are compounds with large pharmaceutical use, which has aroused interest in the search for new drugs to treat diseases. The present study evaluated the cytotoxicity of (-)-trachelogenin, a dibenzylbutyrolactone type lignan isolated from Combretum fruticosum, against …
Lignans are compounds with large pharmaceutical use, which has aroused interest in the search for new drugs to treat diseases. The present s …
Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/beta-catenin signaling pathway in the SW480 colon adenocarcinoma cell line.
Mervai Z, Sólyomváry A, Tóth G, Noszál B, Molnár-Perl I, Baghy K, Kovalszky I, Boldizsár I. Mervai Z, et al. Fitoterapia. 2015 Jan;100:19-26. doi: 10.1016/j.fitote.2014.10.017. Epub 2014 Nov 11. Fitoterapia. 2015. PMID: 25447161
Trachelogenin significantly affected the phosphorylation of key proteins such as beta-Catenin, c-Myc and GSK3 in the beta-Catenin signaling pathway in a concentration-dependent manner. These changes account for the antiproliferative effects of trachelogenin....
Trachelogenin significantly affected the phosphorylation of key proteins such as beta-Catenin, c-Myc and GSK3 in the beta-Catenin sig …
Simultaneous quantification of tracheloside and trachelogenin in rat plasma using liquid chromatography/tandem mass spectrometry.
Li L, Meng F, Guo J, Sun L, Yu N, Zhao Y. Li L, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1033-7. doi: 10.1016/j.jchromb.2011.02.021. Epub 2011 Mar 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 21482203
We developed and validated a quantitative method for simultaneously determining the concentrations of tracheloside and trachelogenin in rat plasma. Plasma samples were prepared by liquid-liquid extraction with ethyl acetate. ...In this study, the validated method was succe …
We developed and validated a quantitative method for simultaneously determining the concentrations of tracheloside and trachelogenin …
Lignans from Trachelospermum jasminoides.
Tan XQ, Chen HS, Liu RH, Tan CH, Xu CL, Xuan WD, Zhang WD. Tan XQ, et al. Planta Med. 2005 Jan;71(1):93-5. doi: 10.1055/s-2005-837761. Planta Med. 2005. PMID: 15678384
Their structures were elucidated to be nortrachelogenin 8' -O-beta-D-glucopyranoside (1), nortrachelogenin 5'- C- beta-D-glucopyranoside (2), trachelogenin amide (3), nortracheloside, trachelogenin, tracheloside, and trachelogenin 4'- O- beta-gentiobioside, r …
Their structures were elucidated to be nortrachelogenin 8' -O-beta-D-glucopyranoside (1), nortrachelogenin 5'- C- beta-D-glucopyranoside (2) …
30 results