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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 3
1977 20
1978 16
1979 37
1980 39
1981 34
1982 40
1983 39
1984 50
1985 53
1986 67
1987 48
1988 32
1989 29
1990 31
1991 31
1992 28
1993 33
1994 46
1995 48
1996 51
1997 60
1998 48
1999 65
2000 65
2001 68
2002 86
2003 72
2004 77
2005 75
2006 73
2007 76
2008 76
2009 60
2010 45
2011 61
2012 69
2013 53
2014 56
2015 52
2016 42
2017 37
2018 38
2019 37
2020 32
2021 36
2022 34
2023 31
2024 16

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2,180 results

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Page 1
Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B(2) Catalyst Under Visible Light Irradiation.
Suga M, Makino K, Tabata H, Oshitari T, Natsugari H, Takahashi H. Suga M, et al. Pharm Res. 2022 Mar;39(3):577-586. doi: 10.1007/s11095-022-03203-3. Epub 2022 Mar 1. Pharm Res. 2022. PMID: 35233730
METHODS: In the presence of 0.05/0.03 equivalents of vitamin B(2)/flavin adenine dinucleotide (FAD), sulindac or ozagrel hydrochloride was irradiated with LED light (405 nm) or fluorescent light. ...Furthermore, ozagrel hydrochloride was more prone to isomerization than …
METHODS: In the presence of 0.05/0.03 equivalents of vitamin B(2)/flavin adenine dinucleotide (FAD), sulindac or ozagrel hydrochlorid …
Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish.
Sun W, Wang M, Zhao J, Zhao S, Zhu W, Wu X, Li F, Liu W, Wang Z, Gao M, Zhang Y, Xu J, Zhang M, Wang Q, Wen Z, Shen J, Zhang W, Huang Z. Sun W, et al. Nat Commun. 2023 Sep 2;14(1):5351. doi: 10.1038/s41467-023-41114-y. Nat Commun. 2023. PMID: 37660128 Free PMC article.
Zebrafish larvae exhibit hyperactive behaviour after sulindac exposure. We also found that akt1 is selectively expressed in GABAergic neurons and that SC97 (an Akt1 activator) and exogenous akt1 mRNA can reverse the apoptosis caused by sulindac. ...Finally, we verif …
Zebrafish larvae exhibit hyperactive behaviour after sulindac exposure. We also found that akt1 is selectively expressed in GABAergic …
Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis.
Burke CA, Dekker E, Lynch P, Samadder NJ, Balaguer F, Hüneburg R, Burn J, Castells A, Gallinger S, Lim R, Stoffel EM, Gupta S, Henderson A, Kallenberg FG, Kanth P, Roos VH, Ginsberg GG, Sinicrope FA, Strassburg CP, Van Cutsem E, Church J, Lalloo F, Willingham FF, Wise PE, Grady WM, Ford M, Weiss JM, Gryfe R, Rustgi AK, Syngal S, Cohen A. Burke CA, et al. N Engl J Med. 2020 Sep 10;383(11):1028-1039. doi: 10.1056/NEJMoa1916063. N Engl J Med. 2020. PMID: 32905675 Clinical Trial.
METHODS: We evaluated the efficacy and safety of the combination of eflornithine and sulindac, as compared with either drug alone, in adults with familial adenomatous polyposis. ...Disease progression occurred in 18 of 56 patients (32%) in the eflornithine-sulindac …
METHODS: We evaluated the efficacy and safety of the combination of eflornithine and sulindac, as compared with either drug alone, in …
The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells.
Miliński M, Staś M, Rok J, Beberok A, Wrześniok D. Miliński M, et al. Pharmacol Rep. 2023 Aug;75(4):995-1004. doi: 10.1007/s43440-023-00493-1. Epub 2023 May 17. Pharmacol Rep. 2023. PMID: 37195561 Free PMC article.
Sulindac also induces apoptosis by changing the ratio of the pro-apoptotic/anti-apoptotic protein. The presented studies indicate the possibility of developing target therapy against melanotic melanoma using sulindac....
Sulindac also induces apoptosis by changing the ratio of the pro-apoptotic/anti-apoptotic protein. The presented studies indicate the …
Clinical pharmacokinetics of sulindac. A dynamic old drug.
Davies NM, Watson MS. Davies NM, et al. Clin Pharmacokinet. 1997 Jun;32(6):437-59. doi: 10.2165/00003088-199732060-00002. Clin Pharmacokinet. 1997. PMID: 9195115 Review.
The absorption of sulindac is rapid when given orally. Sulindac is reversibly metabolised to sulindac sulphide which has anti-inflammatory and analgesic properties and is irreversibly metabolised to sulindac sulphone which has been suggested to possess …
The absorption of sulindac is rapid when given orally. Sulindac is reversibly metabolised to sulindac sulphide which ha …
Oxazole and thiazole analogs of sulindac for cancer prevention.
Mathew B, Hobrath JV, Connelly MC, Guy RK, Reynolds RC. Mathew B, et al. Future Med Chem. 2018 Apr 1;10(7):743-753. doi: 10.4155/fmc-2017-0182. Epub 2018 Apr 19. Future Med Chem. 2018. PMID: 29671617 Free PMC article.
Sulindac sulfide amide (SSA) is an amide-linked sulindac sulfide analog that showed in vivo antitumor activity in a human colon tumor xenograft model. Results/methodology: A new analog series with heterocyclic rings such as oxazole or thiazole at the C-2 position of …
Sulindac sulfide amide (SSA) is an amide-linked sulindac sulfide analog that showed in vivo antitumor activity in a human colo …
Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets.
Liggett JL, Zhang X, Eling TE, Baek SJ. Liggett JL, et al. Cancer Lett. 2014 May 1;346(2):217-24. doi: 10.1016/j.canlet.2014.01.021. Epub 2014 Jan 29. Cancer Lett. 2014. PMID: 24486220 Free PMC article. Review.
In this review, we summarize updated literature regarding cellular and molecular targets modulated by NSAIDs. Among those NSAIDs, sulindac sulfide and tolfenamic acid are emphasized in this review because these two drugs have been well investigated for their anti-tumorigen …
In this review, we summarize updated literature regarding cellular and molecular targets modulated by NSAIDs. Among those NSAIDs, sulinda …
Intermittent Dosing with Sulindac Provides Effective Colorectal Cancer Chemoprevention in the Azoxymethane-Treated Mouse Model.
Chandra S, Nymeyer AC, Rice PF, Gerner EW, Barton JK. Chandra S, et al. Cancer Prev Res (Phila). 2017 Aug;10(8):459-466. doi: 10.1158/1940-6207.CAPR-17-0038. Epub 2017 Jun 13. Cancer Prev Res (Phila). 2017. PMID: 28611038 Free PMC article.
Four treatment groups were studied: (i) daily for 20 weeks (sulindac-daily); (ii) for 2 weeks, then no sulindac for 2 weeks, cycle repeated 5 times (sulindac-2); (iii) for 10 weeks ("on"), then no sulindac for 10 weeks ("off"; sulindac-10); and …
Four treatment groups were studied: (i) daily for 20 weeks (sulindac-daily); (ii) for 2 weeks, then no sulindac for 2 weeks, c …
Pancreatitis and sulindac.
Memon AN. Memon AN. Ann Intern Med. 1982 Jul;97(1):139. doi: 10.7326/0003-4819-97-1-139_1. Ann Intern Med. 1982. PMID: 7091990 No abstract available.
Exisulind in the treatment of prostate cancer.
Webster WS, Leibovich BC. Webster WS, et al. Expert Rev Anticancer Ther. 2005 Dec;5(6):957-62. doi: 10.1586/14737140.5.6.957. Expert Rev Anticancer Ther. 2005. PMID: 16336086 Review.
2,180 results