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Year Number of Results
1964 1
1976 2
1977 1
1978 4
1979 2
1980 8
1981 11
1982 18
1983 27
1984 34
1985 36
1986 31
1987 22
1988 30
1989 30
1990 23
1991 35
1992 52
1993 70
1994 51
1995 53
1996 73
1997 71
1998 71
1999 58
2000 67
2001 87
2002 88
2003 95
2004 97
2005 99
2006 87
2007 96
2008 106
2009 98
2010 101
2011 104
2012 103
2013 100
2014 74
2015 78
2016 54
2017 56
2018 58
2019 65
2020 56
2021 55
2022 46
2023 34
2024 12

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Page 1
Sapropterin dihydrochloride for phenylketonuria.
Somaraju UR, Merrin M. Somaraju UR, et al. Cochrane Database Syst Rev. 2015 Mar 27;2015(3):CD008005. doi: 10.1002/14651858.CD008005.pub4. Cochrane Database Syst Rev. 2015. PMID: 25812600 Free PMC article. Review.
Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride. We examined the evidence for the use of sapropterin dihydrochloride to treat phenylketonuria. ...There are no serious adverse events …
Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride. …
Sapropterin dihydrochloride for phenylketonuria.
Somaraju UR, Merrin M. Somaraju UR, et al. Cochrane Database Syst Rev. 2010 Jun 16;(6):CD008005. doi: 10.1002/14651858.CD008005.pub2. Cochrane Database Syst Rev. 2010. PMID: 20556789 Updated. Review.
Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride. We examined the evidence for the use of sapropterin dihydrochloride to treat phenylketonuria. ...There are no serious adverse events …
Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride. …
Sapropterin dihydrochloride for the treatment of hyperphenylalaninemias.
Blau N. Blau N. Expert Opin Drug Metab Toxicol. 2013 Sep;9(9):1207-18. doi: 10.1517/17425255.2013.804064. Epub 2013 May 27. Expert Opin Drug Metab Toxicol. 2013. PMID: 23705856 Review.
Sapropterin dihydrochloride improves dietary Phe tolerance in about 20% of patients with PKU. ...Sapropterin was well tolerated....
Sapropterin dihydrochloride improves dietary Phe tolerance in about 20% of patients with PKU. ...Sapropterin was well tolerate …
Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia.
Sanford M, Keating GM. Sanford M, et al. Drugs. 2009;69(4):461-76. doi: 10.2165/00003495-200969040-00006. Drugs. 2009. PMID: 19323589 Review.
Sapropterin dihydrochloride (Kuvan), hereafter referred to as sapropterin, is a synthetic formulation of the active 6R-isomer of tetrahydrobiopterin, a naturally occurring cofactor for phenylalanine hydroxylase. ...Over the full 10-week trial, sapropterin and …
Sapropterin dihydrochloride (Kuvan), hereafter referred to as sapropterin, is a synthetic formulation of the active 6R-isomer …
Sapropterin: a new therapeutic agent for phenylketonuria.
Hegge KA, Horning KK, Peitz GJ, Hegge K. Hegge KA, et al. Ann Pharmacother. 2009 Sep;43(9):1466-73. doi: 10.1345/aph.1M050. Epub 2009 Aug 4. Ann Pharmacother. 2009. PMID: 19654333 Review.
Sapropterin has been compared with placebo in one Phase 2 and one Phase 3 clinical trial, demonstrating significantly better response rates. ...When considering sapropterin therapy, clinicians must consider factors such as cost and patient adherence to drug therapy …
Sapropterin has been compared with placebo in one Phase 2 and one Phase 3 clinical trial, demonstrating significantly better response …
Sapropterin dihydrochloride for phenylketonuria.
Somaraju UR, Merrin M. Somaraju UR, et al. Cochrane Database Syst Rev. 2012 Dec 12;12:CD008005. doi: 10.1002/14651858.CD008005.pub3. Cochrane Database Syst Rev. 2012. PMID: 23235653 Updated. Review.
Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride. We examined the evidence for the use of sapropterin dihydrochloride to treat phenylketonuria. ...There are no serious adverse events …
Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride. …
[Phenylketonuria, from diet to gene therapy].
Wiedemann A, Oussalah A, Jeannesson É, Guéant JL, Feillet F. Wiedemann A, et al. Med Sci (Paris). 2020 Aug-Sep;36(8-9):725-734. doi: 10.1051/medsci/2020127. Epub 2020 Aug 21. Med Sci (Paris). 2020. PMID: 32821049 Free article. Review. French.
This treatment must be followed throughout life, which induces severe compliance problems. Drug treatment with sapropterin (or BH4) has come to help a reduced percentage of patients who respond to this drug. ...
This treatment must be followed throughout life, which induces severe compliance problems. Drug treatment with sapropterin (or BH4) h …
Spotlight on sapropterin in primary hyperphenylalaninemia.
Sanford M, Keating GM. Sanford M, et al. BioDrugs. 2009;23(3):201-2. doi: 10.2165/00063030-200923030-00007. BioDrugs. 2009. PMID: 19627172 Review.
Sapropterin was well tolerated in patients with PKU, although longer-term tolerability data are required. ...Thus, sapropterin provides a promising treatment option for patients with PKU who are tetrahydrobiopterin responsive....
Sapropterin was well tolerated in patients with PKU, although longer-term tolerability data are required. ...Thus, sapropterin …
Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice.
Schmitz K, Trautmann S, Hahnefeld L, Fischer C, Schreiber Y, Wilken-Schmitz A, Gurke R, Brunkhorst R, Werner ER, Watschinger K, Wicker S, Thomas D, Geisslinger G, Tegeder I. Schmitz K, et al. Neurotherapeutics. 2021 Jul;18(3):1862-1879. doi: 10.1007/s13311-021-01043-4. Epub 2021 Apr 12. Neurotherapeutics. 2021. PMID: 33844153 Free PMC article.
Sapropterin-treated mice had higher EAE disease scores associated with higher numbers of T-cells infiltrating the spinal cord, but normal T-cell subpopulations in spleen and blood. Mechanistically, sapropterin treatment was associated with increased plasma levels of …
Sapropterin-treated mice had higher EAE disease scores associated with higher numbers of T-cells infiltrating the spinal cord, but no …
Genetics of Phenylketonuria: Then and Now.
Blau N. Blau N. Hum Mutat. 2016 Jun;37(6):508-15. doi: 10.1002/humu.22980. Epub 2016 Mar 18. Hum Mutat. 2016. PMID: 26919687 Review.
2,517 results