Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1952 14
1953 41
1954 24
1955 11
1956 21
1957 25
1958 19
1959 16
1960 17
1961 13
1962 9
1963 36
1964 51
1965 42
1966 44
1967 44
1968 69
1969 63
1970 53
1971 66
1972 69
1973 73
1974 72
1975 62
1976 64
1977 58
1978 42
1979 54
1980 56
1981 78
1982 77
1983 71
1984 93
1985 111
1986 94
1987 106
1988 126
1989 127
1990 128
1991 120
1992 110
1993 135
1994 105
1995 125
1996 133
1997 135
1998 130
1999 115
2000 108
2001 120
2002 153
2003 150
2004 180
2005 193
2006 204
2007 237
2008 185
2009 180
2010 194
2011 216
2012 171
2013 182
2014 175
2015 172
2016 175
2017 169
2018 153
2019 144
2020 166
2021 183
2022 175
2023 170
2024 73

Text availability

Article attribute

Article type

Publication date

Search Results

7,292 results

Results by year

Filters applied: . Clear all
Page 1
The multifaceted antineoplastic role of pyrimethamine against human malignancies.
Ramchandani S, Mohan CD, Mistry JR, Su Q, Naz I, Rangappa KS, Ahn KS. Ramchandani S, et al. IUBMB Life. 2022 Mar;74(3):198-212. doi: 10.1002/iub.2590. Epub 2022 Jan 5. IUBMB Life. 2022. PMID: 34921584 Free article. Review.
Moreover, pyrimethamine has been reported to work in synergy with other anticancer agents, such as temozolomide, to induce apoptosis of tumor cells. ...We have also discussed the pharmacokinetic profile and results of clinical trials obtained after pyrimethamine tre …
Moreover, pyrimethamine has been reported to work in synergy with other anticancer agents, such as temozolomide, to induce apoptosis …
The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy.
Prins HAB, Crespo R, Lungu C, Rao S, Li L, Overmars RJ, Papageorgiou G, Mueller YM, Stoszko M, Hossain T, Kan TW, Rijnders BJA, Bax HI, van Gorp ECM, Nouwen JL, de Vries-Sluijs TEMS, Schurink CAM, de Mendonça Melo M, van Nood E, Colbers A, Burger D, Palstra RJ, van Kampen JJA, van de Vijver DAMC, Mesplède T, Katsikis PD, Gruters RA, Koch BCP, Verbon A, Mahmoudi T, Rokx C. Prins HAB, et al. Sci Adv. 2023 Mar 17;9(11):eade6675. doi: 10.1126/sciadv.ade6675. Epub 2023 Mar 15. Sci Adv. 2023. PMID: 36921041 Free PMC article. Clinical Trial.
Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people living with HIV-1 (PLWH). Twenty-eight PLWH on suppressive antiretroviral therapy were randomized (1:1:1:1 ratio) to receive pyrimethamine, valproic acid, both, or …
Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people living with HIV-1 (PLWH). Twen …
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity.
Rahman Z, Khuroo T, Mohamed EM, Dharani S, Kayalar C, Kuttolamadom MA, Sangaré LO, Khan MA. Rahman Z, et al. Expert Opin Drug Deliv. 2023 Feb;20(2):301-311. doi: 10.1080/17425247.2023.2169272. Epub 2023 Jan 29. Expert Opin Drug Deliv. 2023. PMID: 36639201
OBJECTIVES: The focus of the present research is to develop printlet formulations of pyrimethamine (PMT). METHODS: Printlets formulation of PMT were developed by screening design by varying laser scanning speed, Kollidon VA 64, polyvinylpyrrolidone, and disintegrant. ...
OBJECTIVES: The focus of the present research is to develop printlet formulations of pyrimethamine (PMT). METHODS: Printlets formulat …
Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review.
Ben-Harari RR, Goodwin E, Casoy J. Ben-Harari RR, et al. Drugs R D. 2017 Dec;17(4):523-544. doi: 10.1007/s40268-017-0206-8. Drugs R D. 2017. PMID: 28879584 Free PMC article. Review.
INTRODUCTION: Approximately a third of the population worldwide is chronically infected with Toxoplasma gondii. Pyrimethamine-based regimens are recommended for the treatment of toxoplasmosis. ...Hematologic AEs occurred across all manifestations indicating the importance …
INTRODUCTION: Approximately a third of the population worldwide is chronically infected with Toxoplasma gondii. Pyrimethamine-based r …
Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8(+) T-cell mediated cytotoxicity in colorectal cancer.
Dong H, Hu L, Li W, Shi M, He L, Wang C, Hu Y, Wang H, Wen C, Liu H, Yang X. Dong H, et al. Mol Biol Rep. 2022 Jun;49(6):4281-4292. doi: 10.1007/s11033-022-07262-y. Epub 2022 Mar 9. Mol Biol Rep. 2022. PMID: 35262820 Free PMC article.
The purpose of this study was to investigate the effects and mechanisms of pyrimethamine in CRC. METHODS AND RESULTS: In this study, we assessed the role of pyrimethamine on CRC cell growth by cell counting kit-8 and colony formation assays. ...RNA-seq analysis and …
The purpose of this study was to investigate the effects and mechanisms of pyrimethamine in CRC. METHODS AND RESULTS: In this study, …
Pyrimethamine poisoning.
Akinyanju O, Goddell JC, Ahmed I. Akinyanju O, et al. Br Med J. 1973 Oct 20;4(5885):147-8. doi: 10.1136/bmj.4.5885.147. Br Med J. 1973. PMID: 4543103 Free PMC article. No abstract available.
Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2.
Kim DG, Park CM, Huddar S, Lim S, Kim S, Lee S. Kim DG, et al. Molecules. 2020 Jun 15;25(12):2763. doi: 10.3390/molecules25122763. Molecules. 2020. PMID: 32549310 Free PMC article.
An immunoblot assay in H460 cells showed that pyrimethamine decreased the DX2 level dose-dependently but did not affect the AIMP2 level. ...Analysis of tumor tissue showed a considerably high concentration of pyrimethamine with a decreased levels of DX2. These resul …
An immunoblot assay in H460 cells showed that pyrimethamine decreased the DX2 level dose-dependently but did not affect the AIMP2 lev …
Pyrimethamine in pregnancy.
Harpey JP. Harpey JP. Lancet. 1983 Nov 19;2(8360):1193. doi: 10.1016/s0140-6736(83)91237-0. Lancet. 1983. PMID: 6139544 No abstract available.
Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug.
Posayapisit N, Pengon J, Prommana P, Shoram M, Yuthavong Y, Uthaipibull C, Kamchonwongpaisan S, Jupatanakul N. Posayapisit N, et al. Int J Parasitol. 2021 Jul;51(8):635-642. doi: 10.1016/j.ijpara.2020.12.002. Epub 2021 Mar 11. Int J Parasitol. 2021. PMID: 33713651
Antimalarial drugs capable of targeting multiple parasite stages, particularly the transmissible stages, can be valuable tools for advancing the malaria elimination agenda. Current antifolate drugs such as pyrimethamine can inhibit replicative parasite stages in both human …
Antimalarial drugs capable of targeting multiple parasite stages, particularly the transmissible stages, can be valuable tools for advancing …
7,292 results