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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1913 2
1925 1
1934 1
1945 2
1946 1
1947 4
1948 3
1949 2
1950 5
1951 7
1952 3
1953 1
1954 4
1955 5
1956 8
1957 3
1958 6
1959 13
1960 5
1961 5
1962 23
1963 99
1964 188
1965 130
1966 66
1967 75
1968 101
1969 96
1970 116
1971 123
1972 126
1973 132
1974 128
1975 219
1976 179
1977 159
1978 131
1979 148
1980 147
1981 179
1982 185
1983 215
1984 208
1985 239
1986 234
1987 238
1988 255
1989 266
1990 265
1991 268
1992 280
1993 269
1994 296
1995 320
1996 272
1997 305
1998 287
1999 310
2000 308
2001 343
2002 297
2003 321
2004 323
2005 372
2006 343
2007 405
2008 390
2009 405
2010 445
2011 490
2012 543
2013 560
2014 613
2015 683
2016 653
2017 757
2018 790
2019 829
2020 897
2021 1003
2022 950
2023 974
2024 368

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19,748 results

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Page 1
Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species/JUN Pathway.
Sun Y, Wang J, Guo X, Zhu N, Niu L, Ding X, Xie Z, Chen X, Yang F. Sun Y, et al. Genomics Proteomics Bioinformatics. 2021 Oct;19(5):754-771. doi: 10.1016/j.gpb.2019.06.005. Epub 2021 Feb 23. Genomics Proteomics Bioinformatics. 2021. PMID: 33631425 Free PMC article.
Oleic acid (OA), a monounsaturated fatty acid (MUFA), has previously been shown to reverse saturated fatty acid palmitic acid (PA)-induced hepatic insulin resistance (IR). ...In addition, previous studies have shown that eicosapentaenoic acid …
Oleic acid (OA), a monounsaturated fatty acid (MUFA), has previously been shown to reverse saturated fatty acid palm …
Triglyceride accumulation protects against fatty acid-induced lipotoxicity.
Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, Schaffer JE. Listenberger LL, et al. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3077-82. doi: 10.1073/pnas.0630588100. Epub 2003 Mar 10. Proc Natl Acad Sci U S A. 2003. PMID: 12629214 Free PMC article.
Here, we demonstrate in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates. Oleic acid supplementation leads to triglyceride accumulation and is well tolerated …
Here, we demonstrate in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of t …
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Frietze KK, Brown AM, Das D, Franks RG, Cunningham JL, Hayward M, Nickels JT Jr. Frietze KK, et al. Autophagy. 2022 Jan;18(1):142-160. doi: 10.1080/15548627.2021.1920818. Epub 2021 May 9. Autophagy. 2022. PMID: 33966599 Free PMC article.
In addition to decreased expression of DDX58, we found that DDX58 activity can be attenuated by treatments with palmitic acid (PA), a saturated fatty acid. To investigate whether PA inhibition of DDX58 is harmful to the cell, we characterized DDX58 function i …
In addition to decreased expression of DDX58, we found that DDX58 activity can be attenuated by treatments with palmitic acid …
RIFM fragrance ingredient safety assessment, palmitic acid, CAS Registry Number 57-10-3.
Api AM, Belmonte F, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S. Api AM, et al. Food Chem Toxicol. 2019 Dec;134 Suppl 1:110980. doi: 10.1016/j.fct.2019.110980. Epub 2019 Nov 18. Food Chem Toxicol. 2019. PMID: 31751645 Review. No abstract available.
IGF-1 inhibits palmitic acid-induced mitochondrial apoptosis in macrophages.
Tang W, Zhang M, Wang Y, Ma D, Hu M, Zhang Y, Lin H, Jiang W, Ouyang Y, Jiang L, He P, Zhao G, Ouyang X. Tang W, et al. Mol Med Rep. 2023 Dec;28(6):234. doi: 10.3892/mmr.2023.13121. Epub 2023 Nov 3. Mol Med Rep. 2023. PMID: 37921069 Free PMC article.
However, it is unclear whether IGF-1 has a protective effect on fatty acid-induced macrophages damage. In the present study, THP-1 cells were differentiated into macrophages and stimulated with palmitic acid (PA) in the absence or presence of IGF-1. ...
However, it is unclear whether IGF-1 has a protective effect on fatty acid-induced macrophages damage. In the present study, THP-1 ce …
Linoleic Acid Induced Changes in SZ95 Sebocytes-Comparison with Palmitic Acid and Arachidonic Acid.
Kovács D, Camera E, Póliska S, Cavallo A, Maiellaro M, Dull K, Gruber F, Zouboulis CC, Szegedi A, Törőcsik D. Kovács D, et al. Nutrients. 2023 Jul 26;15(15):3315. doi: 10.3390/nu15153315. Nutrients. 2023. PMID: 37571253 Free PMC article.
Linoleic acid (LA) is an essential omega-6 polyunsaturated fatty acid (PUFA) derived from the diet. Sebocytes, whose primary role is to moisturise the skin, process free fatty acids (FFAs) to produce the lipid-rich sebum. Importantly, like other sebum components suc …
Linoleic acid (LA) is an essential omega-6 polyunsaturated fatty acid (PUFA) derived from the diet. Sebocytes, whose primary r …
Metabolic engineering to produce palmitic acid or palmitoleic acid in an oleic acid-producing Corynebacterium glutamicum strain.
Takeno S, Hirata Y, Kitamura K, Ohtake T, Aoki K, Murata N, Hayashi M, Ikeda M. Takeno S, et al. Metab Eng. 2023 Jul;78:148-158. doi: 10.1016/j.ymben.2023.06.002. Epub 2023 Jun 5. Metab Eng. 2023. PMID: 37286071
Plasmid-mediated amplification of fasB led to a 1.47-fold increase in palmitic acid production (320 mg/L), while fasB disruption resulted in no fatty acid production, with excretion of malonic acid (30 mg/L). Next, aiming at conversion of the palmit …
Plasmid-mediated amplification of fasB led to a 1.47-fold increase in palmitic acid production (320 mg/L), while fasB disrupti …
Free Fatty Acids Induce Lipid Accumulation, Autophagy, and Apoptosis in Human Sebocytes.
Hossini AM, Hou X, Exner T, Fauler B, Eberle J, Rabien A, Makrantonaki E, Zouboulis CC. Hossini AM, et al. Skin Pharmacol Physiol. 2023;36(1):1-15. doi: 10.1159/000527471. Epub 2022 Nov 16. Skin Pharmacol Physiol. 2023. PMID: 36384913
OBJECTIVES: The induction of autophagy and apoptosis in human sebocytes in response to biologically relevant fatty acids was investigated. METHODS: Free fatty acids (arachidonic acid, linoleic acid, palmitic acid, and palmitoleic acid) and the p …
OBJECTIVES: The induction of autophagy and apoptosis in human sebocytes in response to biologically relevant fatty acids was investigated. M …
Period circadian clock 3 inhibits palmitic acid-induced oxidative stress and inflammatory factor secretion in podocytes.
Peng L, Zhang K, Chen K. Peng L, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Nov 28;46(11):1177-1186. doi: 10.11817/j.issn.1672-7347.2021.210019. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021. PMID: 34911851 Free PMC article. Chinese, English.
This study aims to explore the mechanism of period circadian clock 3 (PER3) in the oxidative stress and inflammation induced by palmitic acid (PA) in podocytes. METHODS: The C57BL/6J mice were fed with chow and high-fat diet for 16 weeks. ...This study aims to explo …
This study aims to explore the mechanism of period circadian clock 3 (PER3) in the oxidative stress and inflammation induced by palmitic …
Protein lipidation.
Nadolski MJ, Linder ME. Nadolski MJ, et al. FEBS J. 2007 Oct;274(20):5202-10. doi: 10.1111/j.1742-4658.2007.06056.x. Epub 2007 Sep 24. FEBS J. 2007. PMID: 17892486 Free article. Review.
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