Complete biosynthesis of cannabinoids and their unnatural analogues in yeast.
Luo X, Reiter MA, d'Espaux L, Wong J, Denby CM, Lechner A, Zhang Y, Grzybowski AT, Harth S, Lin W, Lee H, Yu C, Shin J, Deng K, Benites VT, Wang G, Baidoo EEK, Chen Y, Dev I, Petzold CJ, Keasling JD.
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Nature. 2019 Mar;567(7746):123-126. doi: 10.1038/s41586-019-0978-9. Epub 2019 Feb 27.
Nature. 2019.
PMID: 30814733
We also introduced the Cannabis genes that encode the enzymes involved in the biosynthesis of olivetolic acid(6), as well as the gene for a previously undiscovered enzyme with geranylpyrophosphate:olivetolate geranyltransferase activity and the genes for correspondi …
We also introduced the Cannabis genes that encode the enzymes involved in the biosynthesis of olivetolic acid(6), as well as t …