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1998 1
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51 results

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Page 1
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast.
Luo X, Reiter MA, d'Espaux L, Wong J, Denby CM, Lechner A, Zhang Y, Grzybowski AT, Harth S, Lin W, Lee H, Yu C, Shin J, Deng K, Benites VT, Wang G, Baidoo EEK, Chen Y, Dev I, Petzold CJ, Keasling JD. Luo X, et al. Nature. 2019 Mar;567(7746):123-126. doi: 10.1038/s41586-019-0978-9. Epub 2019 Feb 27. Nature. 2019. PMID: 30814733
We also introduced the Cannabis genes that encode the enzymes involved in the biosynthesis of olivetolic acid(6), as well as the gene for a previously undiscovered enzyme with geranylpyrophosphate:olivetolate geranyltransferase activity and the genes for correspondi …
We also introduced the Cannabis genes that encode the enzymes involved in the biosynthesis of olivetolic acid(6), as well as t …
Generation of Cannabigerolic Acid Derivatives and Their Precursors by Using the Promiscuity of the Aromatic Prenyltransferase NphB.
Spitzer S, Wloka J, Pietruszka J, Kayser O. Spitzer S, et al. Chembiochem. 2023 Nov 16;24(22):e202300441. doi: 10.1002/cbic.202300441. Epub 2023 Sep 29. Chembiochem. 2023. PMID: 37690998
It has been demonstrated that cannabigerolic acid is successfully formed by the reaction catalysed by NphB using geranyl diphosphate and olivetolic acid as substrates. In this study, the substrate specificity of NphB was further determined by using olivetolic
It has been demonstrated that cannabigerolic acid is successfully formed by the reaction catalysed by NphB using geranyl diphosphate and …
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs.
Lee YE, Nakashima Y, Kodama T, Chen X, Morita H. Lee YE, et al. Org Lett. 2022 Jan 14;24(1):410-414. doi: 10.1021/acs.orglett.1c04089. Epub 2021 Dec 23. Org Lett. 2022. PMID: 34939812
The therapeutic effects of delta(9)-tetrahydrocannabinol (delta(9)-THC) can be enhanced by modifications of the pentyl moiety at C-3. The engineering of Cannabis sativa olivetolic acid cyclase and tetraketide synthase with F24I and L190G substitutions, respectively, …
The therapeutic effects of delta(9)-tetrahydrocannabinol (delta(9)-THC) can be enhanced by modifications of the pentyl moiety at C-3. The en …
Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome.
Anderson LL, Udoh M, Everett-Morgan D, Heblinski M, McGregor IS, Banister SD, Arnold JC. Anderson LL, et al. J Cannabis Res. 2022 Jan 4;4(1):2. doi: 10.1186/s42238-021-00113-w. J Cannabis Res. 2022. PMID: 34980287 Free PMC article.
Neither CBGA methyl ester nor olivetolic acid displayed pharmacological activity at GPR55 or T-type calcium channels. ...Future studies could explore the anticonvulsant mechanism(s) of action of olivetolic acid and examine whether its anticonvulsant ef …
Neither CBGA methyl ester nor olivetolic acid displayed pharmacological activity at GPR55 or T-type calcium channels. ...Futur …
Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae.
Gülck T, Booth JK, Carvalho Â, Khakimov B, Crocoll C, Motawia MS, Møller BL, Bohlmann J, Gallage NJ. Gülck T, et al. J Nat Prod. 2020 Oct 23;83(10):2877-2893. doi: 10.1021/acs.jnatprod.0c00241. Epub 2020 Oct 1. J Nat Prod. 2020. PMID: 33000946
In a screen of different plant UDP-glycosyltransferases, Stevia rebaudiana SrUGT71E1 and Oryza sativa OsUGT5 were found to glucosylate olivetolic acid, cannabigerolic acid, and delta(9)-tetrahydrocannabinolic acid. Metabolic engineering of N. benthamiana for product …
In a screen of different plant UDP-glycosyltransferases, Stevia rebaudiana SrUGT71E1 and Oryza sativa OsUGT5 were found to glucosylate ol
Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases.
Kearsey LJ, Prandi N, Karuppiah V, Yan C, Leys D, Toogood H, Takano E, Scrutton NS. Kearsey LJ, et al. FEBS J. 2020 Apr;287(8):1511-1524. doi: 10.1111/febs.15089. Epub 2019 Oct 28. FEBS J. 2020. PMID: 31605668 Free PMC article.
In the native pathway to therapeutic cannabinoid biosynthesis in Cannabis sativa, the three-step production of a key intermediate, olivetolic acid, is catalysed by the enzymes tetraketide synthase (TKS; linear tetraketide intermediate production in two stages) and …
In the native pathway to therapeutic cannabinoid biosynthesis in Cannabis sativa, the three-step production of a key intermediate, olivet
Synthetic Pathway for the Production of Olivetolic Acid in Escherichia coli.
Tan Z, Clomburg JM, Gonzalez R. Tan Z, et al. ACS Synth Biol. 2018 Aug 17;7(8):1886-1896. doi: 10.1021/acssynbio.8b00075. Epub 2018 Jul 17. ACS Synth Biol. 2018. PMID: 29976061
Type III polyketide synthases (PKS IIIs) contribute to the synthesis of many economically important natural products, most of which are currently produced by direct extraction from plants or through chemical synthesis. Olivetolic acid (OLA) is a plant secondary meta …
Type III polyketide synthases (PKS IIIs) contribute to the synthesis of many economically important natural products, most of which are curr …
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase for the Formation of Longer Alkyl-Chain Olivetolic Acid Analogs and Their Antibacterial Activities.
Morita H. Morita H. Chem Pharm Bull (Tokyo). 2024;72(1):1-10. doi: 10.1248/cpb.c23-00692. Chem Pharm Bull (Tokyo). 2024. PMID: 38171898 Free article. Review.
This article reviews the structure-based dual engineering of both enzymes responsible for the formation of the resorcinyl core of delta(9)-THC and describes the effect of C-6 alkyl-length extension of olivetolic acid, along with related analogs, on the antibacterial …
This article reviews the structure-based dual engineering of both enzymes responsible for the formation of the resorcinyl core of delta(9)-T …
Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa.
Yang X, Matsui T, Kodama T, Mori T, Zhou X, Taura F, Noguchi H, Abe I, Morita H. Yang X, et al. FEBS J. 2016 Mar;283(6):1088-106. doi: 10.1111/febs.13654. Epub 2016 Feb 2. FEBS J. 2016. PMID: 26783002 Free article.
In polyketide biosynthesis, ring formation is one of the key diversification steps. Olivetolic acid cyclase (OAC) from Cannabis sativa, involved in cannabinoid biosynthesis, is the only known plant polyketide cyclase. In addition, it is the only functionally charact …
In polyketide biosynthesis, ring formation is one of the key diversification steps. Olivetolic acid cyclase (OAC) from Cannabi …
Unravelling Novel Phytochemicals and Anticholinesterase Activity in Irish Cladonia portentosa.
Nagar S, Pigott M, Kukula-Koch W, Sheridan H. Nagar S, et al. Molecules. 2023 May 17;28(10):4145. doi: 10.3390/molecules28104145. Molecules. 2023. PMID: 37241886 Free PMC article.
The hexane extract demonstrated the highest inhibitory activity and was selected for further phytochemical investigations. Olivetolic acid, 4-O-methylolivetolcarboxylic acid, perlatolic acid and usnic acid were isolated and characterized using ESI-MS and two-dimensi …
The hexane extract demonstrated the highest inhibitory activity and was selected for further phytochemical investigations. Olivetolic
51 results