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Year Number of Results
1985 1
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1988 4
1989 3
1990 6
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1992 8
1993 7
1994 2
1995 4
1996 3
1997 1
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2000 2
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2015 5
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Page 1
Intracellular cathepsin C levels determine sensitivity of cells to leucyl-leucine methyl ester-triggered apoptosis.
Kavčič N, Butinar M, Sobotič B, Hafner Česen M, Petelin A, Bojić L, Zavašnik Bergant T, Bratovš A, Reinheckel T, Turk B. Kavčič N, et al. FEBS J. 2020 Dec;287(23):5148-5166. doi: 10.1111/febs.15326. Epub 2020 May 1. FEBS J. 2020. PMID: 32319717 Free article.
L-leucyl-leucine methyl ester (LLOMe) is a lysosomotropic detergent, which was evaluated in clinical trials in graft-vs-host disease because it very efficiently killed monocytic cell lines. ...
L-leucyl-leucine methyl ester (LLOMe) is a lysosomotropic detergent, which was evaluated in clinical trials in g …
The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes.
Ohlin M, Danielsson L, Carlsson R, Borrebaeck CA. Ohlin M, et al. Immunology. 1989 Apr;66(4):485-90. Immunology. 1989. PMID: 2541070 Free PMC article.
These lysosome-rich cells severely inhibit the clonal outgrowth of EBV-infected B cells, as determined by Poisson distribution calculations. Furthermore, leucyl-leucine methyl ester-treated and EBV-infected lymphocytes showed a significant increase in …
These lysosome-rich cells severely inhibit the clonal outgrowth of EBV-infected B cells, as determined by Poisson distribution calculations. …
Apoptosis is induced in cells with cytolytic potential by L-leucyl-L-leucine methyl ester.
Thiele DL, Lipsky PE. Thiele DL, et al. J Immunol. 1992 Jun 15;148(12):3950-7. J Immunol. 1992. PMID: 1602138
Previous studies have demonstrated that the selective toxicity of leucyl-leucine methyl ester (Leu-Leu-OMe) for cytotoxic lymphocytes and myeloid cells is dependent on intracellular conversion to membranolytic metabolites by the acyl transferase activi …
Previous studies have demonstrated that the selective toxicity of leucyl-leucine methyl ester (Leu-Leu-OMe) for …
Human peripheral blood gamma delta T cells are uniformly sensitive to destruction by the lysosomotropic agents leucine methyl ester and leucyl leucine methyl ester.
Pechhold K, Kabelitz D. Pechhold K, et al. Eur J Immunol. 1993 Feb;23(2):562-5. doi: 10.1002/eji.1830230240. Eur J Immunol. 1993. PMID: 8436187
After incubation of PBMC with 5 mM Leu-OMe or incubation of purified T cells with 50 microM leucyl leucine methyl ester (Leu-Leu-OMe) and subsequent overnight culture, CD3-CD16+ NK cells and gamma delta T cells were no longer detectable by immunofluore …
After incubation of PBMC with 5 mM Leu-OMe or incubation of purified T cells with 50 microM leucyl leucine methyl es …
Cell-type specificity of l-leucyl l-leucine methyl ester.
Kobayashi Y, Takasaki A, Kurosaka K, Sakurai Y, Iwamura M, Watanabe N. Kobayashi Y, et al. Biochem Biophys Res Commun. 2000 Jun 16;272(3):687-90. doi: 10.1006/bbrc.2000.2836. Biochem Biophys Res Commun. 2000. PMID: 10860815
77 results