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Page 1
GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.
Lie ME, Gowing EK, Johansen NB, Dalby NO, Thiesen L, Wellendorph P, Clarkson AN. Lie ME, et al. J Cereb Blood Flow Metab. 2019 Jan;39(1):74-88. doi: 10.1177/0271678X17744123. Epub 2017 Nov 21. J Cereb Blood Flow Metab. 2019. PMID: 29160736 Free PMC article.
Therefore, we aimed to assess whether the GAT3 substrate, L-isoserine, could increase post-stroke functional recovery. L-Isoserine (38 M or 380 M) administered directly into the infarct from day 5 to 32 post-stroke, significantly increased motor performance in the g …
Therefore, we aimed to assess whether the GAT3 substrate, L-isoserine, could increase post-stroke functional recovery. L-Isoserine …
Bromo-spiroisoxazoline Alkaloids, Including an Isoserine Peptide, from the Caribbean Marine Sponge Aplysina lacunosa.
Salib MN, Jamison MT, Molinski TF. Salib MN, et al. J Nat Prod. 2020 May 22;83(5):1532-1540. doi: 10.1021/acs.jnatprod.9b01286. Epub 2020 May 1. J Nat Prod. 2020. PMID: 32357010
The structures of 1-3 share the spirocyclohexadienyl-isoxazoline ring system found in purealidin-R and several other Verongid sponge secondary metabolites. Compounds 1 and 2 are coupled to a glycine and an isoserine methyl ester, respectively. Alkaloid 3 is linked, contigu …
The structures of 1-3 share the spirocyclohexadienyl-isoxazoline ring system found in purealidin-R and several other Verongid sponge seconda …
Synthesis of beta(2,2)-Amino Acids by Stereoselective Alkylation of Isoserine Derivatives Followed by Nucleophilic Ring Opening of Quaternary Sulfamidates.
Tovillas P, Navo CD, Oroz P, Avenoza A, Corzana F, Zurbano MM, Jiménez-Osés G, Busto JH, Peregrina JM. Tovillas P, et al. J Org Chem. 2022 Jul 1;87(13):8730-8743. doi: 10.1021/acs.joc.2c01034. Epub 2022 Jun 22. J Org Chem. 2022. PMID: 35732024 Free PMC article.
Chiral bicyclic N,O-acetal isoserine derivatives have been synthesized by an acid-catalyzed tandem N,O-acetalization/intramolecular transcarbamoylation reaction between conveniently protected l-isoserine and 2,2,3,3-tetramethoxybutane. The delicate balance of the st …
Chiral bicyclic N,O-acetal isoserine derivatives have been synthesized by an acid-catalyzed tandem N,O-acetalization/intramolecular t …
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors.
Pan H, Yang K, Zhang J, Xu Y, Jiang Y, Yuan Y, Zhang X, Xu W. Pan H, et al. J Enzyme Inhib Med Chem. 2013 Aug;28(4):717-26. doi: 10.3109/14756366.2012.680062. Epub 2012 Apr 30. J Enzyme Inhib Med Chem. 2013. PMID: 22545941
Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it is over-expressed on the surface of different tumour cells. Based on our previous work that L-isoserine dipeptide derivatives were potent APN inhibitors, we …
Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it is over-expressed on the …
Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation.
Coller BS, Springer KT, Scudder LE, Kutok JL, Ceruso M, Prestwich GD. Coller BS, et al. J Biol Chem. 1993 Oct 5;268(28):20741-3. J Biol Chem. 1993. PMID: 8104935 Free article.
The D-serine derivative resisted degradation in plasma, but it is less than 1% as active as the L-serine peptide. Substituting a racemic mixture of the beta-amino acid isoserine for serine in a related peptide ligand (SFLLRN) produced an active peptide ((iso-S)FLLRN) that …
The D-serine derivative resisted degradation in plasma, but it is less than 1% as active as the L-serine peptide. Substituting a racemic mix …
Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release.
Pomplun S, Shugrue CR, Schmitt AM, Schissel CK, Farquhar CE, Pentelute BL. Pomplun S, et al. Angew Chem Int Ed Engl. 2020 Jul 6;59(28):11566-11572. doi: 10.1002/anie.202003478. Epub 2020 May 8. Angew Chem Int Ed Engl. 2020. PMID: 32227406 Free PMC article.
To overcome this challenge, we report linkers based on secondary amino alcohols for the release of peptides after capture. These amino alcohols are based on serine (seramox) or isoserine (isoseramox) and can be incorporated into peptides during solid-phase peptide synthesi …
To overcome this challenge, we report linkers based on secondary amino alcohols for the release of peptides after capture. These amino alcoh …
Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors.
Yang K, Fen J, Fang H, Zhang L, Gong J, Xu W. Yang K, et al. J Enzyme Inhib Med Chem. 2012 Apr;27(2):302-10. doi: 10.3109/14756361003698147. Epub 2011 Jul 20. J Enzyme Inhib Med Chem. 2012. PMID: 21770859
A series of novel L-isoserine derivatives were synthesised and evaluated for their ability to inhibit aminopeptidase N (APN)/CD13. ...
A series of novel L-isoserine derivatives were synthesised and evaluated for their ability to inhibit aminopeptidase N (APN)/CD13. .. …
IR low-temperature matrix, X-ray and ab initio study on L-isoserine conformations.
Dobrowolski JC, Jamróz MH, Kołos R, Rode JE, Cyrański MK, Sadlej J. Dobrowolski JC, et al. Phys Chem Chem Phys. 2010 Sep 28;12(36):10818-30. doi: 10.1039/c0cp00016g. Epub 2010 Jul 9. Phys Chem Chem Phys. 2010. PMID: 20617269
The IR low-temperature Ar and Kr matrix spectra of l-isoserine were registered for the first time and interpreted by means of the anharmonic DFT frequencies calculated at the B3LYP/aug-cc-pVTZ and B3LYP/aug-cc-pVDZ levels. 54 l-isoserine conformers were predicted to …
The IR low-temperature Ar and Kr matrix spectra of l-isoserine were registered for the first time and interpreted by means of the anh …
57 results