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Antiviral alkaloid principles of the plant family Amaryllidaceae.
Nair JJ, van Staden J. Nair JJ, et al. Phytomedicine. 2023 Jan;108:154480. doi: 10.1016/j.phymed.2022.154480. Epub 2022 Oct 11. Phytomedicine. 2023. PMID: 36240608 Review.
Potent activities were reported in some instances, such as that of trans-dihydronarciclasine against Yellow fever virus (IC(50) 0.003 mug/ml), with minimal effects being manifested on host cells. ...
Potent activities were reported in some instances, such as that of trans-dihydronarciclasine against Yellow fever virus (IC(50) 0.003 …
7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models.
Zhao D, Gu MY, Zhang LJ, Jeon HJ, Cho YB, Yang HO. Zhao D, et al. J Agric Food Chem. 2019 Sep 4;67(35):9796-9804. doi: 10.1021/acs.jafc.9b03307. Epub 2019 Aug 21. J Agric Food Chem. 2019. PMID: 31393712
The extract of Lycoris chejuensis (CJ) and its active compound, 7-deoxy-trans-dihydronarciclasine (named E144), attenuated expressions of pro-inflammatory factors, including nitric oxide, prostaglandin E(2), inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor …
The extract of Lycoris chejuensis (CJ) and its active compound, 7-deoxy-trans-dihydronarciclasine (named E144), attenuated expression …
The First Enantioselective Total Synthesis of (-)-trans-Dihydronarciclasine.
Varró G, Hegedűs L, Simon A, Balogh A, Grün A, Leveles I, Vértessy BG, Kádas I. Varró G, et al. J Nat Prod. 2017 Jun 23;80(6):1909-1917. doi: 10.1021/acs.jnatprod.7b00208. Epub 2017 Jun 5. J Nat Prod. 2017. PMID: 28581297 Free article.
A feasible and enantioselective total synthesis of (-)-trans-dihydronarciclasine [(-)-1], a highly biologically active alkaloid, was devised starting from vanillin (8). ...The total synthesis has provided a facile and first access to the ent-form of naturally occurring (+) …
A feasible and enantioselective total synthesis of (-)-trans-dihydronarciclasine [(-)-1], a highly biologically active alkaloid, was …
Potential Deoxycytidine Kinase Inhibitory Activity of Amaryllidaceae Alkaloids: An In Silico Approach.
Yousef BA, Dirar AI, Elbadawi MAA, Awadalla MK, Mohamed MA. Yousef BA, et al. J Pharm Bioallied Sci. 2018 Jul-Sep;10(3):137-143. doi: 10.4103/jpbs.JPBS_44_18. J Pharm Bioallied Sci. 2018. PMID: 30237684 Free PMC article.
BACKGROUND: Plants of the Amaryllidaceae family have been under intense scrutiny for the presence of a couple of alkaloidal secondary metabolites with endued cytotoxic activity, such as pancratistatin (1), 7-deoxypancratistatin (2), narciclasine (3), 7-deoxynarciclasine (4), tran …
BACKGROUND: Plants of the Amaryllidaceae family have been under intense scrutiny for the presence of a couple of alkaloidal secondary metabo …
Stereocontrolled total synthesis of (+)-trans-dihydronarciclasine.
Hwang S, Kim D, Kim S. Hwang S, et al. Chemistry. 2012 Aug 6;18(32):9977-82. doi: 10.1002/chem.201201649. Epub 2012 Jul 10. Chemistry. 2012. PMID: 22782868
A highly stereoselective and efficient total synthesis of trans-dihydronarciclasine from a readily available chiral starting material was developed. ...
A highly stereoselective and efficient total synthesis of trans-dihydronarciclasine from a readily available chiral starting material …
7-Deoxy-trans-dihydronarciclasine Reduces beta-Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer's Disease.
Chun YS, Zhang L, Li H, Park Y, Chung S, Yang HO. Chun YS, et al. Mol Neurobiol. 2018 Dec;55(12):8953-8964. doi: 10.1007/s12035-018-1023-y. Epub 2018 Apr 4. Mol Neurobiol. 2018. PMID: 29619739
Here, we further explored the effect of its active component, 7-deoxy-trans-dihydronarciclasine (coded as E144), on Abeta generation and the underlying mechanism. ...
Here, we further explored the effect of its active component, 7-deoxy-trans-dihydronarciclasine (coded as E144), on Abeta generation …
()-trans-Dihydronarciclasine and ()-trans-dihydrolycoricidine analogues modified in their ring A: Evaluation of their anticancer activity and a SAR study.
Varró G, Pálchuber P, Pogrányi B, Simon A, Hegedűs L, Kádas I. Varró G, et al. Eur J Med Chem. 2019 Jul 1;173:76-89. doi: 10.1016/j.ejmech.2019.04.010. Epub 2019 Apr 8. Eur J Med Chem. 2019. PMID: 30986573
A series of ()-trans-dihydronarciclasine and ()-trans-dihydrolycoricidine derivatives with variously substituted ring A was synthesised and evaluated for their antiproliferative activity against 60 human tumour cell lines (NCI60), representing leukemia, melanoma, and cance …
A series of ()-trans-dihydronarciclasine and ()-trans-dihydrolycoricidine derivatives with variously substituted ring A was synthesis …
Stereoselective synthesis of trans-dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety.
Varró G, Pogrányi B, Grün A, Simon A, Hegedűs L, Kádas I. Varró G, et al. Monatsh Chem. 2018;149(12):2265-2285. doi: 10.1007/s00706-018-2287-7. Epub 2018 Oct 26. Monatsh Chem. 2018. PMID: 32214482 Free PMC article.
ABSTRACT: Some new trans-dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety were stereoselectively synthesised using our feasible and efficient method developed recently. ...Due to a side reaction, various methoxyphenanthridine regioisomers were also prep …
ABSTRACT: Some new trans-dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety were stereoselectively synthesised usin …
Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor.
McNulty J, Thorat A, Vurgun N, Nair JJ, Makaji E, Crankshaw DJ, Holloway AC, Pandey S. McNulty J, et al. J Nat Prod. 2011 Jan 28;74(1):106-8. doi: 10.1021/np100657w. Epub 2010 Nov 24. J Nat Prod. 2011. PMID: 21105682
The cytochrome P45O activities of the naturally occurring Amaryllidaceae alkaloid narciclasine (3), isolated from Narcissus pseudonarcissus, and synthetic derivative trans-dihydronarciclasine (5) are reported. While narciclasine was found to possess potent inhibitory activ …
The cytochrome P45O activities of the naturally occurring Amaryllidaceae alkaloid narciclasine (3), isolated from Narcissus pseudonarcissus, …
Anti-leukemic effect of a synthetic compound, () trans-dihydronarciclasine (HYU-01) via cell-cycle arrest and apoptosis in acute myeloid leukemia.
Kim SJ, Park HK, Kim JY, Yoon JS, Kim ES, Cho CG, Kim BK, Park BB, Lee YY. Kim SJ, et al. APMIS. 2012 Oct;120(10):836-45. doi: 10.1111/j.1600-0463.2012.02916.x. Epub 2012 May 28. APMIS. 2012. PMID: 22958292
() trans-Dihydronarciclasine, isolated from Chinese medicinal plant Zephyranthes candida, has been shown to possess quite potent anti-tumoral effect against selected human cancer cell lines. However, little is known about the anti-tumoral effect of () trans-dihydronarci …
() trans-Dihydronarciclasine, isolated from Chinese medicinal plant Zephyranthes candida, has been shown to possess quite potent anti …
28 results