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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 3
1984 7
1985 11
1986 3
1987 1
1988 6
1989 23
1990 22
1991 8
1992 15
1993 11
1994 12
1995 11
1996 8
1997 15
1998 14
1999 17
2000 14
2001 10
2002 14
2003 14
2004 9
2005 6
2006 8
2007 12
2008 25
2009 24
2010 19
2011 28
2012 27
2013 26
2014 24
2015 34
2016 29
2017 28
2018 37
2019 38
2020 42
2021 53
2022 53
2023 38
2024 15

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744 results

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Page 1
Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction.
Li D, Zhang G, Wang Z, Guo J, Liu Y, Lu Y, Qin Z, Xu Y, Cao C, Wang B, Guo Q, Wang Y, Liu G, Cui X, Zhang J, Tang J. Li D, et al. Eur J Pharmacol. 2023 Mar 15;943:175569. doi: 10.1016/j.ejphar.2023.175569. Epub 2023 Feb 3. Eur J Pharmacol. 2023. PMID: 36740037 Free article.
Here, we confirmed that the addition of idebenone inhibited H(2)O(2)-induced and RSL3-induced ferroptosis. ...In the MI animal model, idebenone demonstrated a cardioprotective role by regulating ROS-dependent autophagy and inhibiting ferroptosis, which paves the way …
Here, we confirmed that the addition of idebenone inhibited H(2)O(2)-induced and RSL3-induced ferroptosis. ...In the MI animal model, …
Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson's Disease Mice.
Yan A, Liu Z, Song L, Wang X, Zhang Y, Wu N, Lin J, Liu Y, Liu Z. Yan A, et al. Front Cell Neurosci. 2019 Jan 9;12:529. doi: 10.3389/fncel.2018.00529. eCollection 2018. Front Cell Neurosci. 2019. PMID: 30687016 Free PMC article.
Background: Idebenone is an antioxidant and a coenzyme Q10 analog that has been used to treat neurodegeneration disease. Some studies show idebenone exerts anti-inflammatory effects. However, whether idebenone can be used to reduce the neuroinflammation in Pa …
Background: Idebenone is an antioxidant and a coenzyme Q10 analog that has been used to treat neurodegeneration disease. Some studies …
Drug treatment.
Perlman S, Boltshauser E. Perlman S, et al. Handb Clin Neurol. 2018;155:371-377. doi: 10.1016/B978-0-444-64189-2.00024-X. Handb Clin Neurol. 2018. PMID: 29891072 Review.
Idebenone: When an antioxidant is not an antioxidant.
Gueven N, Ravishankar P, Eri R, Rybalka E. Gueven N, et al. Redox Biol. 2021 Jan;38:101812. doi: 10.1016/j.redox.2020.101812. Epub 2020 Nov 25. Redox Biol. 2021. PMID: 33254077 Free PMC article. Review.
Idebenone is a well described drug that was initially developed against dementia. ...Finally, this new appreciation of the molecular activities of idebenone provides a rational approach to test idebenone in novel indications that might have not been considere …
Idebenone is a well described drug that was initially developed against dementia. ...Finally, this new appreciation of the molecular …
Disposition of idebenone (CV-2619), a new cerebral metabolism improving agent, in rats and dogs.
Torii H, Yoshida K, Kobayashi T, Tsukamoto T, Tanayama S. Torii H, et al. J Pharmacobiodyn. 1985 Jun;8(6):457-67. doi: 10.1248/bpb1978.8.457. J Pharmacobiodyn. 1985. PMID: 4057041
After oral administration of 14C-labeled idebenone (14C-CV-2619) to rats, the plasma 14C level reached a plateau at 15 min, which persisted till 8 h and then decreased with a half-life of 4.5 h. ...Enterohepatic cycling of biliary 14C occurred in rats. Repeat …
After oral administration of 14C-labeled idebenone (14C-CV-2619) to rats, the plasma 14C level reached a plateau at 15 …
Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs.
Sugiyama Y, Fujita T, Matsumoto M, Okamoto K, Imada I. Sugiyama Y, et al. J Pharmacobiodyn. 1985 Dec;8(12):1006-17. doi: 10.1248/bpb1978.8.1006. J Pharmacobiodyn. 1985. PMID: 2871147
The effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in isolated brain mitochondria from rats and dogs were studied. ...Reduced CV-2619 (2H-CV-2619) was rapidly oxidized through the …
The effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in isolated brain …
Monogenic mitochondrial disorders.
Koopman WJ, Willems PH, Smeitink JA. Koopman WJ, et al. N Engl J Med. 2012 Mar 22;366(12):1132-41. doi: 10.1056/NEJMra1012478. N Engl J Med. 2012. PMID: 22435372 Free article. Review. No abstract available.
Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia.
Narumi S, Nagai Y, Kakihana M, Yamazaki N, Nagaoka A, Nagawa Y. Narumi S, et al. Jpn J Pharmacol. 1985 Mar;37(3):235-44. doi: 10.1254/jjp.37.235. Jpn J Pharmacol. 1985. PMID: 2582171 Free article.
The effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619) on the contents, turnover, release and uptake of monoamines, especially serotonin (5-HT), in various brain regions of Wistar rats were studied in vivo and in vitro …
The effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619) on the contents, turnov …
Inhibitory effect of idebenone (CV-2619), a novel compound, on vascular lesions in hypertensive rats.
Nagaoka A, Shino A, Kakihana M, Iwatsuka H. Nagaoka A, et al. Jpn J Pharmacol. 1984 Nov;36(3):291-9. doi: 10.1254/jjp.36.291. Jpn J Pharmacol. 1984. PMID: 6521074 Free article.
The effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), on cerebral and renal vascular changes were examined in stroke-prone spontaneously hypertensive rats (SHRSP) and in rats with experimentally ind …
The effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), on c …
744 results