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Page 1
Candesartan.
Gleiter CH, Jägle C, Gresser U, Mörike K. Gleiter CH, et al. Cardiovasc Drug Rev. 2004 Winter;22(4):263-84. doi: 10.1111/j.1527-3466.2004.tb00146.x. Cardiovasc Drug Rev. 2004. PMID: 15592574 Review.
Candesartan cilexetil is the prodrug of candesartan, an angiotensin II receptor antagonist. ...Tolerability of candesartan cilexetil does not differ with either age or gender....
Candesartan cilexetil is the prodrug of candesartan, an angiotensin II receptor antagonist. ...Tolerability of candesartan
Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor.
Ojima M, Inada Y, Shibouta Y, Wada T, Sanada T, Kubo K, Nishikawa K. Ojima M, et al. Eur J Pharmacol. 1997 Jan 14;319(1):137-46. doi: 10.1016/s0014-2999(96)00837-0. Eur J Pharmacol. 1997. PMID: 9030909
The dissociation rate of [3H]CV-11974 binding (t1/2 = 66 min) was 5 times slower than that of [125I]angiotensin II binding (t1/2 = 12 min). These results suggest that the insurmountable antagonism by CV-11974 is due to its slow dissociation from angiot …
The dissociation rate of [3H]CV-11974 binding (t1/2 = 66 min) was 5 times slower than that of [125I]angiotensin II binding (t1 …
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).
Shibouta Y, Inada Y, Ojima M, Wada T, Noda M, Sanada T, Kubo K, Kohara Y, Naka T, Nishikawa K. Shibouta Y, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):114-20. J Pharmacol Exp Ther. 1993. PMID: 8331552
CV-11974 at 10(-5) M did not affect the binding of [125I]AII to subtype 2 (AT2) receptor in bovine cerebellum. ...These effects of CV-11974 and TCV-116 were 12 and 48 times more potent than those of EXP3174 and DuP 753, respectively....
CV-11974 at 10(-5) M did not affect the binding of [125I]AII to subtype 2 (AT2) receptor in bovine cerebellum. ...These effect
Clinical pharmacokinetics of candesartan.
Gleiter CH, Mörike KE. Gleiter CH, et al. Clin Pharmacokinet. 2002;41(1):7-17. doi: 10.2165/00003088-200241010-00002. Clin Pharmacokinet. 2002. PMID: 11825094 Review.
Candesartan cilexetil is the prodrug of candesartan, an angiotensin II type 1 (AT1) receptor antagonist. Absorbed candesartan cilexetil is completely metabolised to candesartan. Oral bioavailability is low (about 40%) because of incomplete absorption.
Candesartan cilexetil is the prodrug of candesartan, an angiotensin II type 1 (AT1) receptor antagonist. Absorbed candesart
CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells.
Sachinidis A, el-Haschimi K, Ko Y, Seul C, Düsing R, Vetter H. Sachinidis A, et al. Biochem Pharmacol. 1996 Jul 12;52(1):123-6. doi: 10.1016/0006-2952(96)00171-2. Biochem Pharmacol. 1996. PMID: 8678895
The exposure of the cells to AII in combination with PDGF-BB or EGF resulted in an approximately 2-fold or 1.5-fold elevation of the AII-dependent effect, respectively. 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimi dazole-7- carboxylic acid (CV-1197
The exposure of the cells to AII in combination with PDGF-BB or EGF resulted in an approximately 2-fold or 1.5-fold elevation of the AII-dep …
CV-11974, angiotensin II type I receptor antagonist, protects against ischemia-reperfusion injury of the small intestine in rats.
Takagi T, Yoshida N, Isozaki Y, Shimozawa M, Katada K, Manabe H, Hanada O, Kokura S, Ichikawa H, Naito Y, Okanoue T, Yoshikawa T. Takagi T, et al. Eur J Pharmacol. 2006 Mar 27;535(1-3):283-90. doi: 10.1016/j.ejphar.2006.02.005. Epub 2006 Mar 20. Eur J Pharmacol. 2006. PMID: 16545368
Pretreatment with CV-11974 significantly inhibited the increases in these parameters. CV-11974 also inhibited increases in intestinal CINC-1 protein and mRNA expression induced by ischemia-reperfusion. ...
Pretreatment with CV-11974 significantly inhibited the increases in these parameters. CV-11974 also inhibited in …
Angiotensin type 1 receptor antagonists CV-11974 and EXP 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats.
Li XC, Widdop RE. Li XC, et al. Clin Sci (Lond). 1996 Aug;91(2):147-54. doi: 10.1042/cs0910147. Clin Sci (Lond). 1996. PMID: 8795437
Spontaneously hypertensive rats and Wistar-Kyoto rats underwent a two-stage operation for the implantation of Doppler flow probes and intravascular catheters to determine the regional haemodynamic profiles of the angiotensin type 1 receptor antagonists, CV-11974 and …
Spontaneously hypertensive rats and Wistar-Kyoto rats underwent a two-stage operation for the implantation of Doppler flow probes and intrav …
Therapeutic effects of candesartan in inflammatory skin disorders by suppressing Th17 differentiation.
Son SE, Im DS. Son SE, et al. Int Immunopharmacol. 2023 Nov;124(Pt B):110995. doi: 10.1016/j.intimp.2023.110995. Epub 2023 Oct 4. Int Immunopharmacol. 2023. PMID: 37801970
CDNB-induced atopic dermatitis-like skin lesions were suppressed by administration of candesartan or telmisartan. The suppressive effect of telmisartan was blocked by the presence of GW9662, a selective PPARgamma inhibitor, but not that of candesartan. Both ARBs sup …
CDNB-induced atopic dermatitis-like skin lesions were suppressed by administration of candesartan or telmisartan. The suppressive eff …
Candesartan in heart failure.
Ripley TL, Chonlahan JS, Germany RE. Ripley TL, et al. Clin Interv Aging. 2006;1(4):357-66. doi: 10.2147/ciia.2006.1.4.357. Clin Interv Aging. 2006. PMID: 18046913 Free PMC article. Review.
Candesartan cilexetil is a nonpeptide selective blocker of the angiotensin II receptor sub-type 1. ...Use of angiotensin receptor blockers with angiotensin-converting enzyme inhibitors needs further study; however, candesartan appears to provide added benefit in thi
Candesartan cilexetil is a nonpeptide selective blocker of the angiotensin II receptor sub-type 1. ...Use of angiotensin receptor blo
Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist.
Noda M, Shibouta Y, Inada Y, Ojima M, Wada T, Sanada T, Kubo K, Kohara Y, Naka T, Nishikawa K. Noda M, et al. Biochem Pharmacol. 1993 Jul 20;46(2):311-8. doi: 10.1016/0006-2952(93)90420-2. Biochem Pharmacol. 1993. PMID: 8347154
CV-11974 showed no appreciable affinity for the AT2 receptors found in bovine cerebellum. ...In contrast, Compound 7-H, which lacks the carboxyl group at the benzimidazole ring of CV-11974, inhibited the contraction in a competitive manner. The inhibit
CV-11974 showed no appreciable affinity for the AT2 receptors found in bovine cerebellum. ...In contrast, Compound 7-H, which
3,618 results