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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 26
1947 51
1948 90
1949 86
1950 150
1951 166
1952 176
1953 192
1954 197
1955 175
1956 184
1957 187
1958 218
1959 180
1960 238
1961 289
1962 319
1963 609
1964 927
1965 584
1966 578
1967 670
1968 798
1969 819
1970 861
1971 1044
1972 1035
1973 1244
1974 1300
1975 1456
1976 1425
1977 1348
1978 1507
1979 1450
1980 1391
1981 1444
1982 1586
1983 1646
1984 1873
1985 1794
1986 1811
1987 1751
1988 1672
1989 1782
1990 1871
1991 1861
1992 1808
1993 1788
1994 1747
1995 1756
1996 1826
1997 1751
1998 1701
1999 1711
2000 2008
2001 1888
2002 1861
2003 2024
2004 1944
2005 2138
2006 2258
2007 2331
2008 2256
2009 2425
2010 2614
2011 2740
2012 2794
2013 2721
2014 2843
2015 2872
2016 2670
2017 2478
2018 2436
2019 2588
2020 2655
2021 2395
2022 2277
2023 2061
2024 655

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106,034 results

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Page 1
[Alkylating agents].
Pourquier P. Pourquier P. Bull Cancer. 2011 Nov;98(11):1237-51. doi: 10.1684/bdc.2011.1471. Bull Cancer. 2011. PMID: 22020797 Free article. Review. French.
Here, we are reviewing the major classes of alkylating agents and their mechanism of action, with a particular emphasis for the new generations of alkylating agents. ...In this line, the development of PARP inhibitors is a striking example of the recen …
Here, we are reviewing the major classes of alkylating agents and their mechanism of action, with a particular emphasis for th …
Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.
Tomar MS, Kumar A, Srivastava C, Shrivastava A. Tomar MS, et al. Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188616. doi: 10.1016/j.bbcan.2021.188616. Epub 2021 Aug 20. Biochim Biophys Acta Rev Cancer. 2021. PMID: 34419533 Review.
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy for glioblastoma multiforme (GBM) and astrocytoma. ...
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy for glioblastoma multiforme (GBM) and astro …
Ecteinascidin-743.
Held-Warmkessel J. Held-Warmkessel J. Clin J Oncol Nurs. 2003 May-Jun;7(3):313-9. doi: 10.1188/03.CJON.313-319. Clin J Oncol Nurs. 2003. PMID: 12793338 Review.
Ecteinascidin-743 (ET-743) is a marine-derived antineoplastic agent undergoing clinical trials to evaluate its use in the treatment of a variety of solid tumors. After the completion of the phase I studies, the agent subsequently was investigated in phase II trials for eff …
Ecteinascidin-743 (ET-743) is a marine-derived antineoplastic agent undergoing clinical trials to evaluate its use in the treatment o …
Rethinking Alkylating(-Like) Agents for Solid Tumor Management.
Lajous H, Lelièvre B, Vauléon E, Lecomte P, Garcion E. Lajous H, et al. Trends Pharmacol Sci. 2019 May;40(5):342-357. doi: 10.1016/j.tips.2019.03.003. Epub 2019 Apr 9. Trends Pharmacol Sci. 2019. PMID: 30979523 Free article. Review.
Although old molecules, alkylating agents and platinum derivatives are still widely used in the treatment of various solid tumors. ...Furthermore, questioning of the old paradigm according to which nuclear DNA is the critical target of their anticancer activity has …
Although old molecules, alkylating agents and platinum derivatives are still widely used in the treatment of various solid tum …
From old alkylating agents to new minor groove binders.
Puyo S, Montaudon D, Pourquier P. Puyo S, et al. Crit Rev Oncol Hematol. 2014 Jan;89(1):43-61. doi: 10.1016/j.critrevonc.2013.07.006. Epub 2013 Aug 20. Crit Rev Oncol Hematol. 2014. PMID: 23972663 Review.
Alkylating agents represent the oldest class of anticancer agents with the approval of mechloretamine by the FDA in 1949. ...These naturally occurring derivatives have a unique mechanism of action that explains the recent regain of interest in developing new …
Alkylating agents represent the oldest class of anticancer agents with the approval of mechloretamine by the FDA in 194 …
The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy.
Ahlmann M, Hempel G. Ahlmann M, et al. Cancer Chemother Pharmacol. 2016 Oct;78(4):661-71. doi: 10.1007/s00280-016-3152-1. Epub 2016 Sep 19. Cancer Chemother Pharmacol. 2016. PMID: 27646791 Review.
Cyclophosphamide is an alkylating agent belonging to the group of oxazaphosporines. As cyclophosphamide is in clinical use for more than 40 years, there is a lot of experience using this drug for the treatment of cancer and as an immunosuppressive agent for the treatment o …
Cyclophosphamide is an alkylating agent belonging to the group of oxazaphosporines. As cyclophosphamide is in clinical use for more t …
Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs.
More GS, Thomas AB, Chitlange SS, Nanda RK, Gajbhiye RL. More GS, et al. Anticancer Agents Med Chem. 2019;19(9):1080-1102. doi: 10.2174/1871520619666190305141458. Anticancer Agents Med Chem. 2019. PMID: 30834842 Review.
Hence it is of great interest to explore this class of anticancer alkylating agents. METHODS: An exhaustive list of reviews, research articles, patents, books, patient information leaflets, and orange book is presented and the contents related to nitrogen mustard an …
Hence it is of great interest to explore this class of anticancer alkylating agents. METHODS: An exhaustive list of reviews, r …
Small-molecule based delivery systems for alkylating antineoplastic compounds.
Bielawski K, Bielawska A. Bielawski K, et al. ChemMedChem. 2008 Apr;3(4):536-42. doi: 10.1002/cmdc.200700229. ChemMedChem. 2008. PMID: 18157855 Review.
Alkylating agents are a major class of anticancer drugs for the treatment of various cancers including hematological malignancies. ...Another approach to overcome the toxicity of alkylating agents to normal tissue is to construct a prodrug with lower h …
Alkylating agents are a major class of anticancer drugs for the treatment of various cancers including hematological malignanc …
ET-743.
Cvetkovic RS, Figgitt DP, Plosker GL. Cvetkovic RS, et al. Drugs. 2002;62(8):1185-92; discussion 1193-4. doi: 10.2165/00003495-200262080-00005. Drugs. 2002. PMID: 12010079 Review.
ET-743 is a novel antineoplastic DNA-binding agent derived from the marine tunicate Ecteinascidia turbinata. ...
ET-743 is a novel antineoplastic DNA-binding agent derived from the marine tunicate Ecteinascidia turbinata. ...
Thiotepa.
National Toxicology Program. National Toxicology Program. Rep Carcinog. 2011;12:406-7. Rep Carcinog. 2011. PMID: 21863106 Free article. No abstract available.
106,034 results
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