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Page 1
Derivatives of 3, 4, 5-Trimethoxycinnamic Acid Ameliorate Stress-Induced Anxiety in Mice and Rats.
Hong E, Min HK, Lim H, Gu SM, Jabborov A, Yayeh T, Kim M, Park WK, Jung JC, Yun J, Oh S. Hong E, et al. Mol Neurobiol. 2023 May;60(5):2737-2748. doi: 10.1007/s12035-023-03240-y. Epub 2023 Jan 30. Mol Neurobiol. 2023. PMID: 36715919
Stress is an overwhelming problem associated with neuronal damage leading to anxiety and depression. The compound 3, 4, 5-trimethoxycinnamic acid (TMCA) has shown anti-stress effects; however, its derivatives remained unknown for their anxiolyti …
Stress is an overwhelming problem associated with neuronal damage leading to anxiety and depression. The compound 3, 4, 5 …
Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.
Zhao Z, Song H, Xie J, Liu T, Zhao X, Chen X, He X, Wu S, Zhang Y, Zheng X. Zhao Z, et al. Eur J Med Chem. 2019 Jul 1;173:213-227. doi: 10.1016/j.ejmech.2019.04.009. Epub 2019 Apr 6. Eur J Med Chem. 2019. PMID: 31009908 Free PMC article. Review.
TMCA (3,4,5-trimethoxycinnamic acid) ester and amide are privileged structural scaffolds in drug discovery which are widely distributed in natural products and consequently produced diverse therapeutically relevant pharmacological functions. ...
TMCA (3,4,5-trimethoxycinnamic acid) ester and amide are privileged structural scaffolds in drug discover …
Synthesis and evaluation of a series of 3,4,5-trimethoxycinnamic acid derivatives as potential antinarcotic agents.
Jung JC, Moon S, Min D, Park WK, Jung M, Oh S. Jung JC, et al. Chem Biol Drug Des. 2013 Mar;81(3):389-98. doi: 10.1111/cbdd.12087. Epub 2012 Dec 26. Chem Biol Drug Des. 2013. PMID: 23121934
A series of 3,4,5-trimethoxycinnamic acid derivatives was prepared and evaluated for antinarcotic effects on morphine dependence in mice and binding affinities on serotonergic receptors. ...We found that the naloxone-induced morphine withdrawal …
A series of 3,4,5-trimethoxycinnamic acid derivatives was prepared and evaluated for antinarcotic effects …
Bacterial degradation of 3,4,5-trimethoxycinnamic acid with production of methanol.
Donnelly MI, Dagley S. Donnelly MI, et al. J Bacteriol. 1981 Aug;147(2):471-6. doi: 10.1128/jb.147.2.471-476.1981. J Bacteriol. 1981. PMID: 7263612 Free PMC article.
When grown on 3,4,5-trimethoxycinnamic acid, a strain of Pseudomonas putida oxidized this compound and also 3,4,5-trimethoxybenzoic, 3,5-dimethoxy-4-hydroxybenzoic (syringic), and 3,4-dihydroxy-5-methoxybenzoic (3-O-methylgallic) acids, but 3,5- …
When grown on 3,4,5-trimethoxycinnamic acid, a strain of Pseudomonas putida oxidized this compound and al …
Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji).
Kawashima K, Miyako D, Ishino Y, Makino T, Saito K, Kano Y. Kawashima K, et al. Biol Pharm Bull. 2004 Aug;27(8):1317-9. doi: 10.1248/bpb.27.1317. Biol Pharm Bull. 2004. PMID: 15305046 Free article.
3,4,5-trimethoxycinnamic acid (TMCA) is one of the constituents in Onji (roots of Polygala tenuifolia WILLD), an herbal medicine used for sedative in Japanese traditional Kampo medicine. ...
3,4,5-trimethoxycinnamic acid (TMCA) is one of the constituents in Onji (roots of Polygala tenuifolia WIL …
3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice.
Lee CI, Han JY, Hong JT, Oh KW. Lee CI, et al. Arch Pharm Res. 2013 Oct;36(10):1244-51. doi: 10.1007/s12272-013-0167-6. Epub 2013 Jul 13. Arch Pharm Res. 2013. PMID: 23852644
These experiments were performed to investigate whether 3,4,5-trimethoxycinnamic acid (TMCA), one of the constituents derived from Polygalae Radix, enhances pentobarbital-induced sleeping behaviors, and to alter sleep architecture through the ga …
These experiments were performed to investigate whether 3,4,5-trimethoxycinnamic acid (TMCA), one of the …
Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives.
Zhao Z, Bai Y, Xie J, Chen X, He X, Sun Y, Bai Y, Zhang Y, Wu S, Zheng X. Zhao Z, et al. Bioorg Chem. 2019 Jul;88:102832. doi: 10.1016/j.bioorg.2019.03.006. Epub 2019 Mar 4. Bioorg Chem. 2019. PMID: 31102809
Epilepsy is a group of neurological disorders characterized by recurrent seizures that disturbs about 60 million people worldwide. In this article, a novel series of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives 1-35 were designed inspi …
Epilepsy is a group of neurological disorders characterized by recurrent seizures that disturbs about 60 million people worldwide. In this a …
3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice.
Chen CY, Wei XD, Chen CR. Chen CY, et al. J Pharmacol Sci. 2016 May;131(1):1-5. doi: 10.1016/j.jphs.2015.07.021. Epub 2015 Jul 28. J Pharmacol Sci. 2016. PMID: 26260747 Free article.
Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix. ...
Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic …
Anti-Wrinkle Effect of Isatis indigotica Leaf Extract: Evaluation of Antioxidant, Anti-Inflammation, and Clinical Activity.
Kim JH, Gao D, Jeong WS, Kim CT, Cho CW, Kim HM, Kang JS. Kim JH, et al. Antioxidants (Basel). 2021 Aug 25;10(9):1339. doi: 10.3390/antiox10091339. Antioxidants (Basel). 2021. PMID: 34572971 Free PMC article.
Among the three fractions, fraction 2 exhibited the highest activity. The major component of the extract was identified as 3,4,5-trimethoxycinnamic acid by liquid chromatography coupled with mass spectrometry. ...
Among the three fractions, fraction 2 exhibited the highest activity. The major component of the extract was identified as 3,4 …
46 results