Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1976 1
1980 1
1981 5
1982 4
1983 1
1984 5
1985 10
1986 18
1987 14
1988 17
1989 16
1990 20
1991 25
1992 22
1993 38
1994 43
1995 48
1996 59
1997 87
1998 91
1999 110
2000 104
2001 132
2002 156
2003 151
2004 150
2005 216
2006 220
2007 221
2008 226
2009 240
2010 250
2011 229
2012 233
2013 241
2014 231
2015 196
2016 199
2017 199
2018 171
2019 159
2020 156
2021 163
2022 132
2023 124
2024 49

Text availability

Article attribute

Article type

Publication date

Search Results

4,620 results

Results by year

Filters applied: . Clear all
Page 1
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.
Ayala A, Muñoz MF, Argüelles S. Ayala A, et al. Oxid Med Cell Longev. 2014;2014:360438. doi: 10.1155/2014/360438. Epub 2014 May 8. Oxid Med Cell Longev. 2014. PMID: 24999379 Free PMC article. Review.
Given the enormity of this field, this review focuses on biochemical concepts of lipid peroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonen …
Given the enormity of this field, this review focuses on biochemical concepts of lipid peroxidation, production, metabolism, and signaling m …
Scavenging 4-Oxo-2-nonenal.
Amarnath V, Amarnath K. Amarnath V, et al. Chem Res Toxicol. 2015 Oct 19;28(10):1888-90. doi: 10.1021/acs.chemrestox.5b00301. Epub 2015 Sep 11. Chem Res Toxicol. 2015. PMID: 26355561 Free PMC article.
4-Oxo-2-nonenal (ONE), a product of cellular lipid oxidation, reacts nonspecifically with the lysine residues of proteins and is generated in increased amounts during degenerative diseases and cancer. ...
4-Oxo-2-nonenal (ONE), a product of cellular lipid oxidation, reacts nonspecifically with the lysine residues of proteins and …
HNE as an inducer of COX-2.
Uchida K. Uchida K. Free Radic Biol Med. 2017 Oct;111:169-172. doi: 10.1016/j.freeradbiomed.2017.02.004. Epub 2017 Feb 9. Free Radic Biol Med. 2017. PMID: 28192229 Review.
COX-2 is induced by various stimuli, including proinflammatory cytokines, to result in PG synthesis associated with inflammation and carcinogenesis. 4-Hydroxy-2-nonenal (HNE) is one of a group of small molecules that can induce COX-2 expression. ...
COX-2 is induced by various stimuli, including proinflammatory cytokines, to result in PG synthesis associated with inflammation and carcino …
Effects of 4-Oxo-2-nonenal on biochemical properties of bovine heart mitochondria.
Mohan A, Kafle D, Singh RK, Hung YC. Mohan A, et al. Food Sci Nutr. 2022 Mar 9;10(6):1830-1840. doi: 10.1002/fsn3.2799. eCollection 2022 Jun. Food Sci Nutr. 2022. PMID: 35702292 Free PMC article.
The effects of lipid peroxidation products 4-Hydroxy-2-nonenal (4-HNE) and 4-oxo-2-nonenal (4-ONE) were evaluated using bovine heart mitochondria. ...
The effects of lipid peroxidation products 4-Hydroxy-2-nonenal (4-HNE) and 4-oxo-2-nonenal (4-ONE) were evaluate …
Antioxidants and HNE in redox homeostasis.
Łuczaj W, Gęgotek A, Skrzydlewska E. Łuczaj W, et al. Free Radic Biol Med. 2017 Oct;111:87-101. doi: 10.1016/j.freeradbiomed.2016.11.033. Epub 2016 Nov 22. Free Radic Biol Med. 2017. PMID: 27888001 Review.
Lipid peroxidation subsequently generates a diverse set of products, including alpha,beta-unsaturated aldehydes. Of these products, 4-hydroxy-2-nonenal (HNE) is the most studied aldehyde on the basis of its involvement in cellular physiology and pathology. ...
Lipid peroxidation subsequently generates a diverse set of products, including alpha,beta-unsaturated aldehydes. Of these products, 4-hydrox …
4-Hydroxy-2-nonenal: a critical target in oxidative stress?
Breitzig M, Bhimineni C, Lockey R, Kolliputi N. Breitzig M, et al. Am J Physiol Cell Physiol. 2016 Oct 1;311(4):C537-C543. doi: 10.1152/ajpcell.00101.2016. Epub 2016 Jul 6. Am J Physiol Cell Physiol. 2016. PMID: 27385721 Free PMC article. Review.
In this perspective, we summarize and discuss critical advancements in the study of 4-hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either caused or exacerbated by oxidative stress. ...
In this perspective, we summarize and discuss critical advancements in the study of 4-hydroxy-2-nonenal (4-HNE) as it relates …
4-hydroxy-2-nonenal as a COX-2 inducer.
Uchida K, Kumagai T. Uchida K, et al. Mol Aspects Med. 2003 Aug-Oct;24(4-5):213-8. doi: 10.1016/s0098-2997(03)00016-5. Mol Aspects Med. 2003. PMID: 12892999 Review.
4-hydroxy-2-nonenal (HNE) activates a variety of signaling pathways. We have recently evaluated the effect of oxidized fatty acid metabolites on cyclooxygenase-2 (COX-2) induction in rat liver epithelial RL34 cells and found that, among the compounds tested, HNE mos …
4-hydroxy-2-nonenal (HNE) activates a variety of signaling pathways. We have recently evaluated the effect of oxidized fatty a …
4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: challenges and opportunities.
Dham D, Roy B, Gowda A, Pan G, Sridhar A, Zeng X, Thandavarayan RA, Palaniyandi SS. Dham D, et al. Free Radic Res. 2021 May;55(5):547-561. doi: 10.1080/10715762.2020.1866756. Epub 2021 Jan 7. Free Radic Res. 2021. PMID: 33336611 Free PMC article. Review.
In oxidative stress, lipid peroxidation-derived reactive carbonyl species such as 4-hydroxy-2-nonenal (4-HNE) is shown to cause damage in organs that leads to diabetic complications. ...
In oxidative stress, lipid peroxidation-derived reactive carbonyl species such as 4-hydroxy-2-nonenal (4-HNE) is shown to caus …
4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways.
Sonowal H, Ramana KV. Sonowal H, et al. Oxid Med Cell Longev. 2019 Nov 6;2019:5937326. doi: 10.1155/2019/5937326. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31781341 Free PMC article. Review.
Recent studies indicate that 4-hydroxy-trans-2-nonenal (HNE), a major oxidative stress triggered lipid peroxidation-derived aldehyde, plays a critical role in the pathophysiology of various human pathologies including metabolic syndrome, diabetes, cardiovascular, ne …
Recent studies indicate that 4-hydroxy-trans-2-nonenal (HNE), a major oxidative stress triggered lipid peroxidation-derived al …
Oxysterols and 4-hydroxy-2-nonenal contribute to atherosclerotic plaque destabilization.
Gargiulo S, Testa G, Gamba P, Staurenghi E, Poli G, Leonarduzzi G. Gargiulo S, et al. Free Radic Biol Med. 2017 Oct;111:140-150. doi: 10.1016/j.freeradbiomed.2016.12.037. Epub 2017 Jan 3. Free Radic Biol Med. 2017. PMID: 28057601 Review.
A growing bulk of evidence suggests that cholesterol oxidation products, known as oxysterols, and 4-hydroxy-2-nonenal (HNE), the major proatherogenic components of oxidized low density lipoproteins (oxLDLs), significantly contribute to atherosclerotic plaque progres …
A growing bulk of evidence suggests that cholesterol oxidation products, known as oxysterols, and 4-hydroxy-2-nonenal (HNE), t …
4,620 results