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6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus.
Averett DR, Koszalka GW, Fyfe JA, Roberts GB, Purifoy DJ, Krenitsky TA. Averett DR, et al. Antimicrob Agents Chemother. 1991 May;35(5):851-7. doi: 10.1128/AAC.35.5.851. Antimicrob Agents Chemother. 1991. PMID: 1649571 Free PMC article.
Seven 6-alkoxypurine arabinosides were synthesized and evaluated for in vitro activity against varicella-zoster virus (VZV). The simplest of the series, 6-methoxypurine arabinoside (ara-M), was the most potent, with 50% inhibitory concentrations ranging from 0.5 to …
Seven 6-alkoxypurine arabinosides were synthesized and evaluated for in vitro activity against varicella-zoster virus (VZV). The simplest of …
2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.
Lambe CU, Averett DR, Paff MT, Reardon JE, Wilson JG, Krenitsky TA. Lambe CU, et al. Cancer Res. 1995 Aug 1;55(15):3352-6. Cancer Res. 1995. PMID: 7614470
However, poor water solubility of ara-G limits clinical use. 2-Amino-6-methoxypurine arabinoside (506U) is a water-soluble prodrug converted to ara-G by adenosine deaminase. 506U is not a substrate for deoxycytidine kinase, adenosine kinase, or purine nucleoside pho …
However, poor water solubility of ara-G limits clinical use. 2-Amino-6-methoxypurine arabinoside (506U) is a water-soluble pro …
Two hydrates of 6-methoxypurine.
Fridman N, Kapon M, Kaftory M. Fridman N, et al. Acta Crystallogr C. 2004 Jan;60(Pt 1):o44-6. doi: 10.1107/s010827010302314x. Epub 2003 Dec 6. Acta Crystallogr C. 2004. PMID: 14712043
6-Methoxypurine crystallizes from N,N-methylformamide as the hemihydrate, C(6)H(6)N(4)O.0.5H(2)O, and from water as the trihydrate, C(6)H(6)N(4)O.3H(2)O. ...
6-Methoxypurine crystallizes from N,N-methylformamide as the hemihydrate, C(6)H(6)N(4)O.0.5H(2)O, and from water as the trihyd …
Suicide gene/prodrug therapy using salmonella-mediated delivery of Escherichia coli purine nucleoside phosphorylase gene and 6-methoxypurine 2'-deoxyriboside in murine mammary carcinoma 4T1 model.
Fu W, Lan H, Liang S, Gao T, Ren D. Fu W, et al. Cancer Sci. 2008 Jun;99(6):1172-9. doi: 10.1111/j.1349-7006.2008.00808.x. Epub 2008 Apr 21. Cancer Sci. 2008. PMID: 18429958 Free article.
Attenuated salmonella have been reported to be capable of both selectively growing in tumors and expressing exogenous genes for tumor-targeted therapy. As 6-methoxypurine 2'-deoxyriboside (MoPdR) is similar to 6-methylpurine 2'-deoxyriboside in structure, we aimed t …
Attenuated salmonella have been reported to be capable of both selectively growing in tumors and expressing exogenous genes for tumor-target …
Selective anabolism of 6-methoxypurine arabinoside in varicella-zoster virus-infected cells.
Biron KK, de Miranda P, Burnette TC, Krenitsky TA. Biron KK, et al. Antimicrob Agents Chemother. 1991 Oct;35(10):2116-20. doi: 10.1128/AAC.35.10.2116. Antimicrob Agents Chemother. 1991. PMID: 1722079 Free PMC article.
6-Methoxypurine arabinoside (ara-M) is a highly selective inhibitor of varicella-zoster virus (VZV). ...
6-Methoxypurine arabinoside (ara-M) is a highly selective inhibitor of varicella-zoster virus (VZV). ...
Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabinoside in rats and monkeys.
Burnette TC, Koszalka GW, Krenitsky TA, De Miranda P. Burnette TC, et al. Antimicrob Agents Chemother. 1991 Jun;35(6):1165-73. doi: 10.1128/AAC.35.6.1165. Antimicrob Agents Chemother. 1991. PMID: 1929259 Free PMC article.
The metabolism and pharmacokinetics of 6-methoxypurine arabinoside (ara-M), a potent and selective inhibitor of varicella-zoster virus, were investigated in rats and monkeys. ...
The metabolism and pharmacokinetics of 6-methoxypurine arabinoside (ara-M), a potent and selective inhibitor of varicella-zost …
Transport of the anti-varicella-zoster virus agent 6-methoxypurine arabinoside and its 2'-O-valerate prodrug into human erythrocytes.
Prus KL, Heidenreich AC, Zimmerman TP. Prus KL, et al. Antimicrob Agents Chemother. 1992 Feb;36(2):283-6. doi: 10.1128/AAC.36.2.283. Antimicrob Agents Chemother. 1992. PMID: 1318676 Free PMC article.
The influx of 6-methoxypurine arabinoside was found to occur primarily by means of the nucleoside transporter. ...(iv) 6-Methoxypurine arabinoside was a competitive inhibitor (Ki = 129 +/- 10 microM) of adenosine influx, and adenosine (Km = 160 +/- 9 m …
The influx of 6-methoxypurine arabinoside was found to occur primarily by means of the nucleoside transporter. ...(iv) 6 …
Neurotoxic effects of the anti-varicella zoster virus agent 2'-valeryl-6-methoxypurine arabinoside in monkeys and rats dosed orally for 90 days.
Szczech GM, Tucker WE Jr. Szczech GM, et al. Fundam Appl Toxicol. 1992 Feb;18(2):314-20. doi: 10.1016/0272-0590(92)90061-l. Fundam Appl Toxicol. 1992. PMID: 1318240
The 2'-valerate ester of 6-methoxypurine arabinoside (170U88), a nucleoside analog with anti-varicella zoster virus (VZV) activity, was given to monkeys and rats. ...
The 2'-valerate ester of 6-methoxypurine arabinoside (170U88), a nucleoside analog with anti-varicella zoster virus (VZV) acti …
Silver(I)-mediated Hoogsteen-type base pairs.
Megger DA, Fonseca Guerra C, Bickelhaupt FM, Müller J. Megger DA, et al. J Inorg Biochem. 2011 Nov;105(11):1398-404. doi: 10.1016/j.jinorgbio.2011.07.005. Epub 2011 Jul 31. J Inorg Biochem. 2011. PMID: 21955841
All artificial base pairs investigated in this study are less stable than the experimentally established benchmark base pair C-Ag(+)-G. The base pair formed from 1,3-dideaza-6-methoxypurine is isoenergetic to the experimentally observed C-Ag(+)-C base pair. This mak …
All artificial base pairs investigated in this study are less stable than the experimentally established benchmark base pair C-Ag(+)-G. The …
Discovery of a cytokinin deaminase.
Goble AM, Fan H, Sali A, Raushel FM. Goble AM, et al. ACS Chem Biol. 2011 Oct 21;6(10):1036-40. doi: 10.1021/cb200198c. Epub 2011 Aug 12. ACS Chem Biol. 2011. PMID: 21823622 Free PMC article.
Additional substrates include N-6-benzyl adenine, cis- and trans-zeatin, kinetin, O-6-methylguanine, N-6-butyladenine, N-6-methyladenine, N,N-dimethyladenine, 6-methoxypurine, 6-chloropurine, and 6-thiomethylpurine. This enzyme does not catalyze the deamination of a …
Additional substrates include N-6-benzyl adenine, cis- and trans-zeatin, kinetin, O-6-methylguanine, N-6-butyladenine, N-6-methyladenine, N, …
46 results