Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1-PGC-1α-TFAM pathway.
Chandrasekaran K, Anjaneyulu M, Choi J, Kumar P, Salimian M, Ho CY, Russell JW.
Chandrasekaran K, et al.
Int Rev Neurobiol. 2019;145:177-209. doi: 10.1016/bs.irn.2019.04.002. Epub 2019 Jun 8.
Int Rev Neurobiol. 2019.
PMID: 31208524
Free PMC article.
Review.
Knockout of PGC-1alpha exacerbates DPN, whereas overexpression of human TFAM is protective. LY379268, a selective metabolomic glutamate receptor 2/3 (mGluR2/3) receptor agonist, also upregulates the SIRT1/PGC-1alpha/TFAM signaling pathway and prevents DPN through glutamate …
Knockout of PGC-1alpha exacerbates DPN, whereas overexpression of human TFAM is protective. LY379268, a selective metabolomic glutama …