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2016 14
2017 23
2024 0

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35 results

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Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL. Qi W, et al. Nat Med. 2017 Jun;23(6):753-762. doi: 10.1038/nm.4328. Epub 2017 Apr 24. Nat Med. 2017. PMID: 28436957 Free PMC article.
A past and present overview of macrophage metabolism and functional outcomes.
Curi R, de Siqueira Mendes R, de Campos Crispin LA, Norata GD, Sampaio SC, Newsholme P. Curi R, et al. Clin Sci (Lond). 2017 Jun 15;131(12):1329-1342. doi: 10.1042/CS20170220. Clin Sci (Lond). 2017. PMID: 28592702 Review.
Macrophages also utilize fatty acids for both energy production in the mitochondria and lipid synthesis essential to plasma membrane turnover and lipid meditator production. Recent studies utilizing metabolomic approaches, transcriptional and metabolite tracking technologi …
Macrophages also utilize fatty acids for both energy production in the mitochondria and lipid synthesis essential to plasma membrane turnove …
Second Era of OMICS in Caries Research: Moving Past the Phase of Disillusionment.
Nascimento MM, Zaura E, Mira A, Takahashi N, Ten Cate JM. Nascimento MM, et al. J Dent Res. 2017 Jul;96(7):733-740. doi: 10.1177/0022034517701902. Epub 2017 Apr 6. J Dent Res. 2017. PMID: 28384412 Free PMC article. Review.
For example, the determination of complete bacterial microbiomes of oral samples rather than selected species, together with oral metatranscriptome and metabolome analyses, supports the viewpoint of dysbiosis of the supragingival biofilms. In addition, metabolome st …
For example, the determination of complete bacterial microbiomes of oral samples rather than selected species, together with oral metatransc …
Metabolomic Profiling in Individuals with a Failing Kidney Allograft.
Bassi R, Niewczas MA, Biancone L, Bussolino S, Merugumala S, Tezza S, D'Addio F, Ben Nasr M, Valderrama-Vasquez A, Usuelli V, De Zan V, El Essawy B, Venturini M, Secchi A, De Cobelli F, Lin A, Chandraker A, Fiorina P. Bassi R, et al. PLoS One. 2017 Jan 4;12(1):e0169077. doi: 10.1371/journal.pone.0169077. eCollection 2017. PLoS One. 2017. PMID: 28052095 Free PMC article.
BACKGROUND: Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. METHODS: To explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by liquid chromatography-mass spectrometry (LC-MS/MS; …
BACKGROUND: Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. METHODS: To explore meta …
Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis.
Lv LX, Fang DQ, Shi D, Chen DY, Yan R, Zhu YX, Chen YF, Shao L, Guo FF, Wu WR, Li A, Shi HY, Jiang XW, Jiang HY, Xiao YH, Zheng SS, Li LJ. Lv LX, et al. Environ Microbiol. 2016 Jul;18(7):2272-86. doi: 10.1111/1462-2920.13401. Environ Microbiol. 2016. PMID: 27243236
UPLC-MS/MS assaying of small molecules was used to characterize the metabolomes of the serum, urine and feces. Liquid chip assaying of serum cytokines was used to characterize the immune profiles. ...
UPLC-MS/MS assaying of small molecules was used to characterize the metabolomes of the serum, urine and feces. Liquid chip assaying o …
The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds.
Johnson JD. Johnson JD. Diabetologia. 2016 Oct;59(10):2047-57. doi: 10.1007/s00125-016-4059-4. Epub 2016 Jul 29. Diabetologia. 2016. PMID: 27473069 Review.
There are justified calls for more detailed and well-powered studies of primary human pancreatic beta cell physiology, and I propose online databases of standardised human beta cell responses to physiological stimuli, including both functional and metabolomic/proteomic/tra …
There are justified calls for more detailed and well-powered studies of primary human pancreatic beta cell physiology, and I propose online …
Cortisol-related metabolic alterations assessed by mass spectrometry assay in patients with Cushing's syndrome.
Di Dalmazi G, Quinkler M, Deutschbein T, Prehn C, Rayes N, Kroiss M, Berr CM, Stalla G, Fassnacht M, Adamski J, Reincke M, Beuschlein F. Di Dalmazi G, et al. Eur J Endocrinol. 2017 Aug;177(2):227-237. doi: 10.1530/EJE-17-0109. Epub 2017 May 31. Eur J Endocrinol. 2017. PMID: 28566446
The aim of this study was to characterize metabolic alterations in patients with different degrees of hypercortisolism by mass-spectrometry-based targeted plasma metabolomic profiling and correlate the metabolomic profile with clinical and hormonal data. ...Clinical …
The aim of this study was to characterize metabolic alterations in patients with different degrees of hypercortisolism by mass-spectrometry- …
Functional and Metabolomic Consequences of K(ATP) Channel Inactivation in Human Islets.
Li C, Ackermann AM, Boodhansingh KE, Bhatti TR, Liu C, Schug J, Doliba N, Han B, Cosgrove KE, Banerjee I, Matschinsky FM, Nissim I, Kaestner KH, Naji A, Adzick NS, Dunne MJ, Stanley CA, De León DD. Li C, et al. Diabetes. 2017 Jul;66(7):1901-1913. doi: 10.2337/db17-0029. Epub 2017 Apr 25. Diabetes. 2017. PMID: 28442472 Free PMC article.
Proteomic and metabolomic analysis reveals rapid and extensive nicotine detoxification ability in honey bee larvae.
du Rand EE, Human H, Smit S, Beukes M, Apostolides Z, Nicolson SW, Pirk CW. du Rand EE, et al. Insect Biochem Mol Biol. 2017 Mar;82:41-51. doi: 10.1016/j.ibmb.2017.01.011. Epub 2017 Feb 1. Insect Biochem Mol Biol. 2017. PMID: 28161469
Due to the characteristic intensive brood care displayed by honey bees, which includes progressive feeding throughout larval development, it is generally assumed that larvae rely on adults to detoxify for them and exhibit a diminished detoxification ability. We found the opposite …
Due to the characteristic intensive brood care displayed by honey bees, which includes progressive feeding throughout larval development, it …
35 results