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Year Number of Results
2019 766
2020 1444
2021 1361
2022 1226
2023 1429
2024 437

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6,272 results

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Cellular senescence in ageing: from mechanisms to therapeutic opportunities.
Di Micco R, Krizhanovsky V, Baker D, d'Adda di Fagagna F. Di Micco R, et al. Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95. doi: 10.1038/s41580-020-00314-w. Epub 2020 Dec 16. Nat Rev Mol Cell Biol. 2021. PMID: 33328614 Free PMC article. Review.
Senescent cell extrinsic activities, broadly related to the activation of a senescence-associated secretory phenotype, amplify the impact of cell-intrinsic proliferative arrest and contribute to impaired tissue regeneration, chronic age-associated diseases and organ
Senescent cell extrinsic activities, broadly related to the activation of a senescence-associated secretory phenotype, amplify
NAD(+) metabolism and its roles in cellular processes during ageing.
Covarrubias AJ, Perrone R, Grozio A, Verdin E. Covarrubias AJ, et al. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. Nat Rev Mol Cell Biol. 2021. PMID: 33353981 Free PMC article. Review.
NAD(+) can directly and indirectly influence many key cellular functions, including metabolic pathways, DNA repair, chromatin remodelling, cellular senescence and immune cell function. These cellular processes and functions are critical for maintaining tissue and metabolic …
NAD(+) can directly and indirectly influence many key cellular functions, including metabolic pathways, DNA repair, chromatin remodelling, c …
Chemically induced reprogramming to reverse cellular aging.
Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, Angeli S, Gladyshev VN, Sinclair DA. Yang JH, et al. Aging (Albany NY). 2023 Jul 12;15(13):5966-5989. doi: 10.18632/aging.204896. Epub 2023 Jul 12. Aging (Albany NY). 2023. PMID: 37437248 Free PMC article.
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals can restore youthful DNA methylation patterns, transcript p …
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the …
Molecular mechanisms of dietary restriction promoting health and longevity.
Green CL, Lamming DW, Fontana L. Green CL, et al. Nat Rev Mol Cell Biol. 2022 Jan;23(1):56-73. doi: 10.1038/s41580-021-00411-4. Epub 2021 Sep 13. Nat Rev Mol Cell Biol. 2022. PMID: 34518687 Free PMC article. Review.
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and extending healthspan and lifespan in diverse species, including rodents and non-human primates. In this Review, we discuss the effects of dietary restriction in these mammalian …
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and extending healthspan and lifespan in …
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Kulkarni AS, Gubbi S, Barzilai N. Kulkarni AS, et al. Cell Metab. 2020 Jul 7;32(1):15-30. doi: 10.1016/j.cmet.2020.04.001. Epub 2020 Apr 24. Cell Metab. 2020. PMID: 32333835 Free PMC article. Review.
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting ef …
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. …
Ageing and rejuvenation of tissue stem cells and their niches.
Brunet A, Goodell MA, Rando TA. Brunet A, et al. Nat Rev Mol Cell Biol. 2023 Jan;24(1):45-62. doi: 10.1038/s41580-022-00510-w. Epub 2022 Jul 20. Nat Rev Mol Cell Biol. 2023. PMID: 35859206 Free PMC article. Review.
In this Review, we discuss cellular and molecular mechanisms underlying ageing in the regenerative regions of different tissues as well as potential rejuvenation strategies. ...We also compare different interventions for the rejuvenation of old regenerative r …
In this Review, we discuss cellular and molecular mechanisms underlying ageing in the regenerative regions of different tissues as we …
Telomere dysfunction in ageing and age-related diseases.
Rossiello F, Jurk D, Passos JF, d'Adda di Fagagna F. Rossiello F, et al. Nat Cell Biol. 2022 Feb;24(2):135-147. doi: 10.1038/s41556-022-00842-x. Epub 2022 Feb 14. Nat Cell Biol. 2022. PMID: 35165420 Free PMC article. Review.
Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are pr
Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage
The ageing epigenome and its rejuvenation.
Zhang W, Qu J, Liu GH, Belmonte JCI. Zhang W, et al. Nat Rev Mol Cell Biol. 2020 Mar;21(3):137-150. doi: 10.1038/s41580-019-0204-5. Epub 2020 Feb 4. Nat Rev Mol Cell Biol. 2020. PMID: 32020082 Review.
Several 'rejuvenating' interventions have been proposed to delay ageing and the onset of age-associated decline and disease to extend healthspan and lifespan. ...This Review discusses the epigenetic changes that occur during ageing and the rapidly increasing …
Several 'rejuvenating' interventions have been proposed to delay ageing and the onset of age-associated decline and disease to extend …
Mitochondrial dysfunction in aging.
Guo Y, Guan T, Shafiq K, Yu Q, Jiao X, Na D, Li M, Zhang G, Kong J. Guo Y, et al. Ageing Res Rev. 2023 Jul;88:101955. doi: 10.1016/j.arr.2023.101955. Epub 2023 May 15. Ageing Res Rev. 2023. PMID: 37196864 Review.
Although abundant interventions on MQC have been explored, over-activation or inhibition of any type of MQC may even accelerate abnormal energy metabolism and mitochondrial dysfunction-induced senescence. This review summarizes mechanisms essential for maintaining mitochon …
Although abundant interventions on MQC have been explored, over-activation or inhibition of any type of MQC may even accelerate abnormal ene …
Autophagy and the hallmarks of aging.
Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM. Kaushik S, et al. Ageing Res Rev. 2021 Dec;72:101468. doi: 10.1016/j.arr.2021.101468. Epub 2021 Sep 24. Ageing Res Rev. 2021. PMID: 34563704 Free PMC article. Review.
However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with other determinants of aging, is placing autophagy at the center of the aging process. In this work, we summarize evidence for the …
However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with oth …
6,272 results