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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 3
1972 2
1975 5
1976 2
1977 8
1978 3
1979 2
1980 4
1981 3
1982 3
1983 4
1984 3
1985 1
1986 5
1987 11
1988 5
1989 6
1990 14
1991 9
1992 13
1993 17
1994 22
1995 10
1996 24
1997 9
1998 22
1999 13
2000 10
2001 14
2002 9
2003 18
2004 18
2005 24
2006 19
2007 17
2008 19
2009 21
2010 16
2011 14
2012 25
2013 32
2014 28
2015 29
2016 32
2017 33
2018 18
2019 41
2020 39
2021 38
2022 30
2023 25
2024 7

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758 results

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Page 1
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.
Pagán AJ, Lee LJ, Edwards-Hicks J, Moens CB, Tobin DM, Busch-Nentwich EM, Pearce EL, Ramakrishnan L. Pagán AJ, et al. Among authors: ramakrishnan l. Cell. 2022 Sep 29;185(20):3720-3738.e13. doi: 10.1016/j.cell.2022.08.018. Epub 2022 Sep 13. Cell. 2022. PMID: 36103894 Free PMC article.
Through a zebrafish forward genetic screen, we identified the mTOR kinase, a master regulator of metabolism, as an early host resistance factor in tuberculosis. We found that mTOR complex 1 protects macrophages from mycobacterium-induced death by enabling infection- …
Through a zebrafish forward genetic screen, we identified the mTOR kinase, a master regulator of metabolism, as an early host resistance fac …
Stepwise pathogenic evolution of Mycobacterium abscessus.
Bryant JM, Brown KP, Burbaud S, Everall I, Belardinelli JM, Rodriguez-Rincon D, Grogono DM, Peterson CM, Verma D, Evans IE, Ruis C, Weimann A, Arora D, Malhotra S, Bannerman B, Passemar C, Templeton K, MacGregor G, Jiwa K, Fisher AJ, Blundell TL, Ordway DJ, Jackson M, Parkhill J, Floto RA. Bryant JM, et al. Among authors: floto ra, blundell tl. Science. 2021 Apr 30;372(6541):eabb8699. doi: 10.1126/science.abb8699. Science. 2021. PMID: 33926925 Free PMC article.
Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as Mycobacterium tuberculosis, have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of the environmental organism M. abscessus …
Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as Mycobacterium tuberculosis, …
100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.
100,000 Genomes Project Pilot Investigators; Smedley D, Smith KR, Martin A, Thomas EA, McDonagh EM, Cipriani V, Ellingford JM, Arno G, Tucci A, Vandrovcova J, Chan G, Williams HJ, Ratnaike T, Wei W, Stirrups K, Ibanez K, Moutsianas L, Wielscher M, Need A, Barnes MR, Vestito L, Buchanan J, Wordsworth S, Ashford S, Rehmström K, Li E, Fuller G, Twiss P, Spasic-Boskovic O, Halsall S, Floto RA, Poole K, Wagner A, Mehta SG, Gurnell M, Burrows N, James R, Penkett C, Dewhurst E, Gräf S, Mapeta R, Kasanicki M, Haworth A, Savage H, Babcock M, Reese MG, Bale M, Baple E, Boustred C, Brittain H, de Burca A, Bleda M, Devereau A, Halai D, Haraldsdottir E, Hyder Z, Kasperaviciute D, Patch C, Polychronopoulos D, Matchan A, Sultana R, Ryten M, Tavares ALT, Tregidgo C, Turnbull C, Welland M, Wood S, Snow C, Williams E, Leigh S, Foulger RE, Daugherty LC, Niblock O, Leong IUS, Wright CF, Davies J, Crichton C, Welch J, Woods K, Abulhoul L, Aurora P, Bockenhauer D, Broomfield A, Cleary MA, Lam T, Dattani M, Footitt E, Ganesan V, Grunewald S, Compeyrot-Lacassagne S, Muntoni F, Pilkington C, Quinlivan R, Thapar N, Wallis C, Wedderburn LR, Worth A, Bueser T, Compton C, Deshpande C, Fassihi H, Haque … See abstract for full author list ➔ 100,000 Genomes Project Pilot Investigators, et al. Among authors: floto ra. N Engl J Med. 2021 Nov 11;385(20):1868-1880. doi: 10.1056/NEJMoa2035790. N Engl J Med. 2021. PMID: 34758253 Free PMC article.
Revisiting the role of the granuloma in tuberculosis.
Ramakrishnan L. Ramakrishnan L. Nat Rev Immunol. 2012 Apr 20;12(5):352-66. doi: 10.1038/nri3211. Nat Rev Immunol. 2012. PMID: 22517424 Review.
The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of tuberculosis. It is historically regarded as a host-protective structure that 'walls off' the infecting mycobacteria. ...An understanding of the mechanisms and impact of tuberc …
The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of tuberculosis. It is historically regarded a …
Latent Tuberculosis: Two Centuries of Confusion.
Behr MA, Kaufmann E, Duffin J, Edelstein PH, Ramakrishnan L. Behr MA, et al. Among authors: ramakrishnan l. Am J Respir Crit Care Med. 2021 Jul 15;204(2):142-148. doi: 10.1164/rccm.202011-4239PP. Am J Respir Crit Care Med. 2021. PMID: 33761302 Free PMC article. No abstract available.
TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.
Roca FJ, Whitworth LJ, Redmond S, Jones AA, Ramakrishnan L. Roca FJ, et al. Among authors: ramakrishnan l. Cell. 2019 Sep 5;178(6):1344-1361.e11. doi: 10.1016/j.cell.2019.08.004. Epub 2019 Aug 29. Cell. 2019. PMID: 31474371 Free PMC article.
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish infected with Mycobacterium marinum or Mycobacterium tuberculosis …
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the …
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, … See abstract for full author list ➔ Klionsky DJ, et al. Among authors: floto ra. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Autophagy. 2016. PMID: 26799652 Free PMC article. No abstract available.
An Overview.
Blundell TL. Blundell TL. Prog Biophys Mol Biol. 2022 Sep;173:1-3. doi: 10.1016/j.pbiomolbio.2022.07.001. Epub 2022 Jul 14. Prog Biophys Mol Biol. 2022. PMID: 35842061 No abstract available.
British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).
Haworth CS, Banks J, Capstick T, Fisher AJ, Gorsuch T, Laurenson IF, Leitch A, Loebinger MR, Milburn HJ, Nightingale M, Ormerod P, Shingadia D, Smith D, Whitehead N, Wilson R, Floto RA. Haworth CS, et al. Among authors: floto ra. Thorax. 2017 Nov;72(Suppl 2):ii1-ii64. doi: 10.1136/thoraxjnl-2017-210927. Thorax. 2017. PMID: 29054853 Review. No abstract available.
Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport.
Roca FJ, Whitworth LJ, Prag HA, Murphy MP, Ramakrishnan L. Roca FJ, et al. Among authors: ramakrishnan l. Science. 2022 Jun 24;376(6600):eabh2841. doi: 10.1126/science.abh2841. Epub 2022 Jun 24. Science. 2022. PMID: 35737799 Free PMC article.
In zebrafish, we identified the mechanism of TNF-induced mROS in tuberculosis. Excess TNF in mycobacterium-infected macrophages elevates mROS production by reverse electron transport (RET) through complex I. ...The complex I inhibitor metformin, a widely used antidi …
In zebrafish, we identified the mechanism of TNF-induced mROS in tuberculosis. Excess TNF in mycobacterium-infected macrophage …
758 results