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    DUSP7 dual specificity phosphatase 7 [ Homo sapiens (human) ]

    Gene ID: 1849, updated on 5-Mar-2024

    Summary

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    Official Symbol
    DUSP7provided by HGNC
    Official Full Name
    dual specificity phosphatase 7provided by HGNC
    Primary source
    HGNC:HGNC:3073
    See related
    Ensembl:ENSG00000164086 MIM:602749; AllianceGenome:HGNC:3073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKPX; PYST2
    Summary
    Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
    Expression
    Ubiquitous expression in esophagus (RPKM 18.5), skin (RPKM 16.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3p21.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (52048919..52056571, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (52081823..52089474, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52082935..52090587, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52027370-52028102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52038485-52039365 Neighboring gene ribosomal protein L29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52049045-52049924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52052748-52053510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52053511-52054273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19925 Neighboring gene Sharpr-MPRA regulatory region 12856 Neighboring gene uncharacterized LOC105377088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52065550-52066066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52066067-52066581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52073992-52074561 Neighboring gene uncharacterized LOC124906238 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:52080336-52081535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52101953-52102546 Neighboring gene long intergenic non-protein coding RNA 696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52104737-52105238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52112399-52113318 Neighboring gene POC1 centriolar protein A Neighboring gene Sharpr-MPRA regulatory region 14635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19927 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52187832-52188809

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway. Bai H, et al. J Cell Mol Med, 2021 Oct. PMID 34435746, Free PMC Article
    2. Does the dual-specificity MAPK phosphatase Pyst2-L lead a monogamous relationship with the Erk2 protein? Orlev LN, et al. Immunol Lett, 2004 Mar 29. PMID 15081539
    3. cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. Levy-Nissenbaum O, et al. Methods Enzymol, 2003. PMID 14674243
    4. Characterization of the dual-specificity phosphatase PYST2 and its transcripts. Levy-Nissenbaum O, et al. Genes Chromosomes Cancer, 2004 Jan. PMID 14603440
    5. Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. Levy-Nissenbaum O, et al. Oncogene, 2003 Oct 23. PMID 14576828

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
      Title: Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
    2. DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway.
      Title: DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway.
    3. DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.
      Title: DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.
    4. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of early arthritis.
      Title: mRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis.
    5. overexpressed in acute myelogenous leukemia
      Title: cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia.
    6. high levels of Pyst2-L detected in the active state of AML and ALL diseases and in other types of cancer reflect an altered MAPK signaling pathway in such malignant processes
      Title: Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp586F2224

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade TAS
    Traceable Author Statement
    more info
    		  
    involved_in MAPK cascade TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 7
    Names
    dual specificity protein phosphatase PYST2
    NP_001938.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001947.4 → NP_001938.2  dual specificity protein phosphatase 7

      See identical proteins and their annotated locations for NP_001938.2

      Status: VALIDATED

      Source sequence(s)
      AC115284, AL110157, BC019107, CN429806, DN999200, X93921
      Consensus CDS
      CCDS33766.2
      UniProtKB/Swiss-Prot
      Q16829, Q2M3J7, Q8NFJ0
      Related
      ENSP00000417183.1, ENST00000495880.2
      Conserved Domains (2) summary
      cd01446
      Location:55 → 186
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14643
      Location:240 → 388
      DSP_DUSP7; dual specificity phosphatase domain of dual specificity protein phosphatase 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      52048919..52056571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      52081823..52089474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16829.4 GenPept UniProtKB/Swiss-Prot:Q16829

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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