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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 2
1973 8
1974 2
1975 7
1976 12
1977 6
1979 5
1980 8
1981 4
1982 9
1983 5
1984 19
1985 4
1986 12
1987 9
1988 16
1989 16
1990 9
1991 8
1992 5
1993 5
1994 15
1995 3
1996 7
1997 7
1998 2
1999 13
2000 7
2001 3
2002 3
2003 7
2004 7
2005 5
2006 2
2007 8
2008 4
2009 6
2010 4
2011 6
2012 4
2013 6
2014 8
2015 7
2016 4
2017 5
2018 3
2019 4
2020 8
2021 5
2022 3
2023 5
2024 2

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335 results

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Page 1
Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.
Morin CM, Chen SJ, Ivers H, Beaulieu-Bonneau S, Krystal AD, Guay B, Bélanger L, Cartwright A, Simmons B, Lamy M, Busby M, Edinger JD. Morin CM, et al. JAMA Netw Open. 2023 Dec 1;6(12):e2349638. doi: 10.1001/jamanetworkopen.2023.49638. JAMA Netw Open. 2023. PMID: 38153735 Free PMC article. Clinical Trial.
INTERVENTIONS: Participants were randomly assigned to either BT or zolpidem as first-stage therapy, and those whose insomnia had not remitted received a second-stage psychological therapy (BT or cognitive therapy) or medication therapy (zolpidem or trazodone). MAIN OUTCOME …
INTERVENTIONS: Participants were randomly assigned to either BT or zolpidem as first-stage therapy, and those whose insomnia had not remitte …
Second-generation antidepressants.
Rudorfer MV, Golden RN, Potter WZ. Rudorfer MV, et al. Psychiatr Clin North Am. 1984 Sep;7(3):519-34. Psychiatr Clin North Am. 1984. PMID: 6237317 Review.
Effect of trazodone versus cognitive-behavioural treatment on high- and slow-frequency activity during non-rapid eye movement sleep in chronic insomnia: A pilot, randomized clinical trial.
Li Y, Vgontzas AN, Fernandez-Mendoza J, Fang J, Puzino K, Bixler EO. Li Y, et al. J Sleep Res. 2021 Oct;30(5):e13324. doi: 10.1111/jsr.13324. Epub 2021 Mar 5. J Sleep Res. 2021. PMID: 33675113 Clinical Trial.
Trazodone and cognitive-behavioural treatment for insomnia (CBT-I) are widely used to treat patients with chronic insomnia. ...In conclusion, trazodone, but not CBT-I, decreased fast-frequency EEG activity during NREM sleep. ...
Trazodone and cognitive-behavioural treatment for insomnia (CBT-I) are widely used to treat patients with chronic insomnia. ...In con …
Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.
Davis JL, Schirmer J, Medlin E. Davis JL, et al. J Vet Pharmacol Ther. 2018 Jun;41(3):393-401. doi: 10.1111/jvp.12477. Epub 2018 Jan 14. J Vet Pharmacol Ther. 2018. PMID: 29333613 Free PMC article. Clinical Trial.
The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of oral trazodone in clinical horses. Six experimental horses were administered trazodone at 7.5 or 10 mg/kg. Plasma concentratio …
The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of …
Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson's disease and sleep disorders: a randomized, double-blind trial.
Hadi F, Agah E, Tavanbakhsh S, Mirsepassi Z, Mousavi SV, Talachi N, Tafakhori A, Aghamollaii V. Hadi F, et al. Neurol Sci. 2022 Oct;43(10):6141-6148. doi: 10.1007/s10072-022-06188-4. Epub 2022 Jun 6. Neurol Sci. 2022. PMID: 35660990 Clinical Trial.
Melatonin intake was associated with a higher decrease in RBDSQ score compared to trazodone (P = 0.011) and clonazepam (P = 0.004). Trazodone intake was associated with a higher decrease in ESS score compared to clonazepam (P = 0.010). Mild adverse events were repor …
Melatonin intake was associated with a higher decrease in RBDSQ score compared to trazodone (P = 0.011) and clonazepam (P = 0.004). …
Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs.
Roth AJ, McCall WV, Liguori A. Roth AJ, et al. J Sleep Res. 2011 Dec;20(4):552-8. doi: 10.1111/j.1365-2869.2011.00928.x. Epub 2011 May 30. J Sleep Res. 2011. PMID: 21623982 Free PMC article. Clinical Trial.
Trazodone is prescribed widely as a sleep aid, although it is indicated for depression, not insomnia. ...On day 7 only, slow wave sleep was greater and objective measures of daytime sleepiness lower with trazodone than with placebo. Although trazodone is effi …
Trazodone is prescribed widely as a sleep aid, although it is indicated for depression, not insomnia. ...On day 7 only, slow wave sle …
Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis : A Randomized Clinical Trial.
Mehrotra R, Cukor D, McCurry SM, Rue T, Roumelioti ME, Heagerty PJ, Unruh M. Mehrotra R, et al. Ann Intern Med. 2024 Feb;177(2):177-188. doi: 10.7326/M23-1794. Epub 2024 Jan 16. Ann Intern Med. 2024. PMID: 38224591 Clinical Trial.
RESULTS: A total of 923 patients were prescreened, and of the 411 patients with chronic insomnia, 126 were randomly assigned to CBT-I (n = 43), trazodone (n = 42), or placebo (n = 41). The change in ISI scores from baseline to 7 weeks with CBT-I or trazodone was no …
RESULTS: A total of 923 patients were prescreened, and of the 411 patients with chronic insomnia, 126 were randomly assigned to CBT-I (n = 4 …
Antidepressant properties of trazodone.
Bryant SG, Ereshefsky L. Bryant SG, et al. Clin Pharm. 1982 Sep-Oct;1(5):406-17. Clin Pharm. 1982. PMID: 6764164 Review.
Trazodone has few cardiovascular side effects. In patients ingesting toxic amounts of trazodone, no deaths have been reported unless other drugs were present or ingested concomitantly. The usual adult daily dose of trazodone hydrochloride is 150-400 mg given …
Trazodone has few cardiovascular side effects. In patients ingesting toxic amounts of trazodone, no deaths have been reported …
Trazodone as an Alternative Treatment for Neuroleptic-Associated Akathisia: A Placebo-Controlled, Double-Blind, Clinical Trial.
Shams-Alizadeh N, Maroufi A, Asadi Z, Rahmani K, Hassanzadeh K. Shams-Alizadeh N, et al. J Clin Psychopharmacol. 2020 Nov/Dec;40(6):611-614. doi: 10.1097/JCP.0000000000001286. J Clin Psychopharmacol. 2020. PMID: 33044356 Clinical Trial.
RESULTS: Patients receiving trazodone did not show a significant difference compared with the control group in terms of the severity of akathisia symptoms until the third day of the study. In contrast, at the end of the fifth day, there was a significant improvement in obj …
RESULTS: Patients receiving trazodone did not show a significant difference compared with the control group in terms of the severity …
Investigations on dose proportionality and drug-drug interaction for a fixed-dose combination of trazodone and gabapentin.
Ruggieri A, Picollo R, Del Vecchio A, Calisti F, Dragone P, Comandini A, Rosignoli MT, Cattaneo A, Donath F, Wedemeyer RS, Todorova-Sanjari M, Warnke A, Blume HH. Ruggieri A, et al. Int J Clin Pharmacol Ther. 2021 Jan;59(1):71-86. doi: 10.5414/CP203845. Int J Clin Pharmacol Ther. 2021. PMID: 33040841 Clinical Trial.
OBJECTIVES: To establish dose proportionality for trazodone and gabapentin at fixed ratios of trazodone/gabapentin 2.5/25, 10/100, and 30/300 and investigation of potential drug-drug interaction at a dose of 10/100. ...A validated liquid chromatography-tandem mass s …
OBJECTIVES: To establish dose proportionality for trazodone and gabapentin at fixed ratios of trazodone/gabapentin 2.5/25, 10/ …
335 results